HIPHOP chemogenomics database

YDL150W / RPC53

RNA polymerase III subunit C53

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDL150W / RPC53

Click on Significant Values for Screen Details

Top fitness defect scores for YDL150W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2612	dictamnine	15.50	15.5 µM	1.30E-27	RNA pol III & RNase P/MRP	5	2.63E-54	1.80
2	SGTC_1834	st055981	14.30	52.8 µM	8.18E-24	RPP1 & pyrimidine depletion	1	1.50E-46	6.91
3	SGTC_1915	st067105	14.10	30.6 µM	3.43E-23	RNA pol III & RNase P/MRP	4	2.79E-45	1.46
4	SGTC_1930	st074634	13.40	34.3 µM	3.02E-21	RNA pol III & RNase P/MRP	3	2.58E-41	5.05
5	SGTC_2544	sphondin	12.90	68.5 µM	9.51E-20	RNA pol III & RNase P/MRP	4	2.91E-38	2.43
6	SGTC_2393	9031399	12.60	185.9 µM	4.09E-19	RNA processing & uracil transport	1	5.68E-37	6.15
7	SGTC_2057	5236571	11.30	38.3 µM	1.06E-15	RPP1 & pyrimidine depletion	4	4.97E-30	0.44
8	SGTC_2411	st077133	8.35	39.9 µM	2.26E-9	RNA pol III & RNase P/MRP	9	3.32E-17	0.66
9	SGTC_2306	7482397	8.32	179.5 µM	2.55E-9	RPP1 & pyrimidine depletion	4	4.23E-17	2.02
10	SGTC_832	4083-0019	7.97	164.0 µM	1.08E-8	translation	2	7.77E-16	0.55
11	SGTC_2738	aclarubicin	7.96	5.5 µM	1.15E-8	RNA pol III & RNase P/MRP	3	8.84E-16	0.60
12	SGTC_2522	biochanin a	7.80	4.9 µM	2.12E-8	RNA pol III & RNase P/MRP	3	3.03E-15	0.55
13	SGTC_2601	securinine	7.67	100.0 µM	3.52E-8		2	8.35E-15	0.05
14	SGTC_1377	2944-0135	7.41	198.0 µM	9.60E-8	calcium & mitochondrial duress	1	6.29E-14	1.69
15	SGTC_800	3448-7362	7.26	155.0 µM	1.71E-7	translation	16	2.01E-13	0.48
16	SGTC_1840	st055363	7.22	71.0 µM	1.94E-7		1	2.59E-13	2.23
17	SGTC_625	k213-0058	6.95	121.0 µM	5.16E-7	translation	2	1.83E-12	0.80
18	SGTC_611	3453-1652	6.90	23.7 µM	6.18E-7		6	2.63E-12	0.27
19	SGTC_118	0083-0097	6.56	135.3 µM	2.00E-6	translation	3	2.75E-11	0.20
20	SGTC_3136	9095672	6.48	49.5 µM	2.60E-6		1	4.65E-11	2.04

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.457	3.20E-173	YDL152W_d	YDL152W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
0.431	5.06E-152	YOR116C	RPO31	het	RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.355	2.78E-100	YOR207C	RET1	het	Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.237	3.62E-44	YNL221C	POP1	het	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.221	1.88E-38	YJR007W	SUI2	het	Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.209	2.65E-34	YBR154C	RPB5	het	RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.200	1.81E-31	YBR257W	POP4	het	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.192	3.12E-29	YPL238C_d	YPL238C_d	het	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.186	2.31E-27	YHR062C	RPP1	het	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.185	2.87E-27	YGR083C	GCD2	het	Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.184	4.62E-27	YNL248C	RPA49	hom	RNA polymerase I subunit A49
0.184	4.96E-27	YER025W	GCD11	het	Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
0.172	1.40E-23	YDR211W	GCD6	het	Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.171	2.05E-23	YLR291C	GCD7	het	Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.171	2.36E-23	YPL237W	SUI3	het	Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding