YDL151C_d / BUD30

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL151C / BUD30

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:-3.35|P-value:5.71E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.27|P-value:1.75E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:3.49|P-value:4.24E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.05|P-value:6.44E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:4.24|P-value:2.42E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:5.18|P-value:3.39E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.62|P-value:4.70E-6 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.40|P-value:5.67E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.43|P-value:5.16E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:4.27|P-value:2.13E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:5.13|P-value:4.37E-7 ID:SGTC_595|Compound:3909-8003|FD-Score:3.49|P-value:4.22E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.35|P-value:1.55E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.38|P-value:5.25E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.05|P-value:5.16E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:5.87|P-value:8.73E-9 ID:SGTC_997|Compound:3996-0078|FD-Score:5.86|P-value:9.54E-9 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.39|P-value:1.29E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.54|P-value:3.56E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.67|P-value:3.72E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.64|P-value:2.49E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:6.30|P-value:7.46E-10 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.74|P-value:1.73E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.28|P-value:8.52E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.88|P-value:8.64E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.33|P-value:6.30E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.31|P-value:7.70E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.26|P-value:8.93E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.20|P-value:2.83E-5 ID:SGTC_2127|Compound:5253358|FD-Score:4.18|P-value:3.04E-5 ID:SGTC_2134|Compound:5324836|FD-Score:4.65|P-value:4.08E-6 ID:SGTC_2187|Compound:6125751|FD-Score:4.28|P-value:2.01E-5 ID:SGTC_2321|Compound:7390090|FD-Score:7.09|P-value:5.07E-12 ID:SGTC_2332|Compound:7982454|FD-Score:3.70|P-value:1.96E-4 ID:SGTC_2351|Compound:9026858|FD-Score:7.19|P-value:2.52E-12 ID:SGTC_2393|Compound:9031399|FD-Score:4.70|P-value:3.35E-6 ID:SGTC_2402|Compound:5553605|FD-Score:-5.72|P-value:1.56E-8 ID:SGTC_2403|Compound:6032726|FD-Score:3.40|P-value:5.69E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.39|P-value:5.98E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.63|P-value:2.51E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:5.00|P-value:8.04E-7 ID:SGTC_2468|Compound:5987765|FD-Score:3.36|P-value:6.45E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-6.02|P-value:2.97E-9 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.71|P-value:1.65E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.51|P-value:3.93E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.09|P-value:4.42E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.10|P-value:4.31E-5 ID:SGTC_2831|Compound:7999036|FD-Score:4.86|P-value:1.61E-6 ID:SGTC_2927|Compound:9011802|FD-Score:4.71|P-value:3.22E-6 ID:SGTC_2949|Compound:9072542|FD-Score:-3.89|P-value:8.18E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.24|P-value:9.62E-4 ID:SGTC_3014|Compound:9081533|FD-Score:7.11|P-value:4.35E-12 ID:SGTC_3018|Compound:9082602|FD-Score:-4.02|P-value:4.96E-5 ID:SGTC_3210|Compound:9128157|FD-Score:3.29|P-value:8.31E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.61|P-value:2.77E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.28|P-value:2.09E-5 ID:SGTC_57|Compound:miconazole|FD-Score:-3.35|P-value:5.71E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.27|P-value:1.75E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:3.49|P-value:4.24E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.05|P-value:6.44E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:4.24|P-value:2.42E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:5.18|P-value:3.39E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.62|P-value:4.70E-6 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.40|P-value:5.67E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.43|P-value:5.16E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:4.27|P-value:2.13E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:5.13|P-value:4.37E-7 ID:SGTC_595|Compound:3909-8003|FD-Score:3.49|P-value:4.22E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.35|P-value:1.55E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.38|P-value:5.25E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.05|P-value:5.16E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:5.87|P-value:8.73E-9 ID:SGTC_997|Compound:3996-0078|FD-Score:5.86|P-value:9.54E-9 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.39|P-value:1.29E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.54|P-value:3.56E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.67|P-value:3.72E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.64|P-value:2.49E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:6.30|P-value:7.46E-10 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.74|P-value:1.73E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.28|P-value:8.52E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.88|P-value:8.64E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.33|P-value:6.30E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.31|P-value:7.70E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.26|P-value:8.93E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.20|P-value:2.83E-5 ID:SGTC_2127|Compound:5253358|FD-Score:4.18|P-value:3.04E-5 ID:SGTC_2134|Compound:5324836|FD-Score:4.65|P-value:4.08E-6 ID:SGTC_2187|Compound:6125751|FD-Score:4.28|P-value:2.01E-5 ID:SGTC_2321|Compound:7390090|FD-Score:7.09|P-value:5.07E-12 ID:SGTC_2332|Compound:7982454|FD-Score:3.70|P-value:1.96E-4 ID:SGTC_2351|Compound:9026858|FD-Score:7.19|P-value:2.52E-12 ID:SGTC_2393|Compound:9031399|FD-Score:4.70|P-value:3.35E-6 ID:SGTC_2402|Compound:5553605|FD-Score:-5.72|P-value:1.56E-8 ID:SGTC_2403|Compound:6032726|FD-Score:3.40|P-value:5.69E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.39|P-value:5.98E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.63|P-value:2.51E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:5.00|P-value:8.04E-7 ID:SGTC_2468|Compound:5987765|FD-Score:3.36|P-value:6.45E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-6.02|P-value:2.97E-9 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.71|P-value:1.65E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.51|P-value:3.93E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.09|P-value:4.42E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.10|P-value:4.31E-5 ID:SGTC_2831|Compound:7999036|FD-Score:4.86|P-value:1.61E-6 ID:SGTC_2927|Compound:9011802|FD-Score:4.71|P-value:3.22E-6 ID:SGTC_2949|Compound:9072542|FD-Score:-3.89|P-value:8.18E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.24|P-value:9.62E-4 ID:SGTC_3014|Compound:9081533|FD-Score:7.11|P-value:4.35E-12 ID:SGTC_3018|Compound:9082602|FD-Score:-4.02|P-value:4.96E-5 ID:SGTC_3210|Compound:9128157|FD-Score:3.29|P-value:8.31E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.61|P-value:2.77E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.28|P-value:2.09E-5

Top fitness defect scores for YDL151C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2351 9026858 7.19 72.3 µM 2.52E-12 RNA processing & uracil transport 2 3.25E-13
2 SGTC_3014 9081533 7.11 49.5 µM 4.35E-12 1 5.85E-13
3 SGTC_2321 7390090 7.09 138.8 µM 5.07E-12 2 6.91E-13
4 SGTC_1274 0865-0114 6.30 173.0 µM 7.46E-10 3 1.51E-10
5 SGTC_830 4076-0286 5.87 57.8 µM 8.73E-9 translation 19 2.15E-9
6 SGTC_997 3996-0078 5.86 137.0 µM 9.54E-9 4 2.37E-9
7 SGTC_115 0527-0192 5.18 112.0 µM 3.39E-7 28 1.12E-7
8 SGTC_544 k015-0020 5.13 52.4 µM 4.37E-7 4 1.47E-7
9 SGTC_103 0844-0104 5.05 51.8 µM 6.44E-7 ERAD & cell cycle 99 2.23E-7
10 SGTC_2417 cerulenin 5.00 830.0 nM 8.04E-7 10 2.83E-7
11 SGTC_2831 7999036 4.86 19.5 µM 1.61E-6 20 6.01E-7
12 SGTC_2927 9011802 4.71 47.9 µM 3.22E-6 14 1.27E-6
13 SGTC_2393 9031399 4.70 185.9 µM 3.35E-6 RNA processing & uracil transport 16 1.32E-6
14 SGTC_1180 1193-0155 4.67 285.0 µM 3.72E-6 4 1.48E-6
15 SGTC_2134 5324836 4.65 1.5 µM 4.08E-6 9 1.63E-6
16 SGTC_221 trifluoperazine 4.62 10.3 µM 4.70E-6 NEO1-PIK1 179 1.91E-6
17 SGTC_1127 asiatic acid 4.39 681.4 nM 1.29E-5 16 5.65E-6
18 SGTC_625 k213-0058 4.35 121.0 µM 1.55E-5 translation 79 6.89E-6
19 SGTC_2187 6125751 4.28 200.0 µM 2.01E-5 RSC complex & mRNA processing 10 9.14E-6
20 SGTC_3319 9138450 4.28 16.8 µM 2.09E-5 15 9.55E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.39E-13 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.120 2.95E-12 YPR132W RPS23B hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.119 4.86E-12 YBR021W FUR4 hom Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
0.115 2.46E-11 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.102 2.98E-9 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.097 2.09E-8 YBR168W PEX32 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.097 2.02E-8 YOR078W BUD21 hom Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.097 2.18E-8 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.096 2.25E-8 YDR434W GPI17 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog
0.095 3.32E-8 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.093 7.44E-8 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.092 9.34E-8 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.089 2.20E-7 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.089 2.20E-7 YJR042W NUP85 het Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
0.089 2.77E-7 YCR035C RRP43 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress