YDL152W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL152W / YDL152W

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:-4.52|P-value:3.44E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:-4.28|P-value:6.60E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-4.17|P-value:9.03E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.73|P-value:9.53E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.25|P-value:3.80E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:7.26|P-value:6.53E-9 ID:SGTC_203|Compound:k066-0004|FD-Score:4.19|P-value:4.48E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.08|P-value:6.07E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.64|P-value:1.24E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:4.30|P-value:3.35E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:4.02|P-value:7.26E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.82|P-value:7.03E-5 ID:SGTC_486|Compound:niguldipine|FD-Score:3.94|P-value:8.92E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:-4.93|P-value:1.03E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.71|P-value:3.58E-6 ID:SGTC_516|Compound:3992-2719|FD-Score:6.64|P-value:9.70E-8 ID:SGTC_539|Compound:4859-0462|FD-Score:10.50|P-value:1.21E-16 ID:SGTC_586|Compound:0957-0265|FD-Score:8.15|P-value:9.45E-11 ID:SGTC_673|Compound:1082-0474|FD-Score:9.95|P-value:4.25E-15 ID:SGTC_685|Compound:1278-0033|FD-Score:-4.48|P-value:3.86E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.76|P-value:8.53E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.97|P-value:8.31E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.27|P-value:3.64E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.75|P-value:6.74E-10 ID:SGTC_802|Compound:4112-3352|FD-Score:4.58|P-value:1.47E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.42|P-value:2.36E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-5.51|P-value:1.59E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:6.89|P-value:3.32E-8 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-5.27|P-value:3.60E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.03|P-value:6.92E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:4.79|P-value:7.87E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.18|P-value:6.21E-7 ID:SGTC_1229|Compound:0139-0193|FD-Score:5.35|P-value:1.27E-5 ID:SGTC_1471|Compound:k673-0312|FD-Score:4.09|P-value:5.93E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-6.57|P-value:3.28E-7 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-7.53|P-value:5.66E-9 ID:SGTC_1706|Compound:st031321|FD-Score:-4.54|P-value:3.27E-4 ID:SGTC_1711|Compound:st032263|FD-Score:4.14|P-value:5.24E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.94|P-value:8.81E-4 ID:SGTC_1814|Compound:st052110|FD-Score:5.35|P-value:1.28E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.98|P-value:8.05E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.89|P-value:5.78E-5 ID:SGTC_1915|Compound:st067105|FD-Score:18.90|P-value:4.02E-49 ID:SGTC_1930|Compound:st074634|FD-Score:7.58|P-value:1.52E-9 ID:SGTC_2057|Compound:5236571|FD-Score:5.21|P-value:2.05E-5 ID:SGTC_2086|Compound:5274770|FD-Score:4.10|P-value:5.81E-4 ID:SGTC_2156|Compound:5649887|FD-Score:4.34|P-value:2.99E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.93|P-value:5.06E-5 ID:SGTC_2306|Compound:7482397|FD-Score:4.53|P-value:1.72E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-4.16|P-value:9.16E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-4.16|P-value:9.08E-4 ID:SGTC_2393|Compound:9031399|FD-Score:6.50|P-value:1.74E-7 ID:SGTC_2396|Compound:5342950|FD-Score:5.30|P-value:1.51E-5 ID:SGTC_2411|Compound:st077133|FD-Score:10.90|P-value:1.18E-17 ID:SGTC_2477|Compound:5967686|FD-Score:3.96|P-value:8.36E-4 ID:SGTC_2480|Compound:5767542|FD-Score:5.44|P-value:9.38E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.16|P-value:4.86E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:7.25|P-value:6.78E-9 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.81|P-value:7.41E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:7.53|P-value:1.92E-9 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.50|P-value:3.65E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:6.20|P-value:5.66E-7 ID:SGTC_2738|Compound:aclarubicin|FD-Score:7.35|P-value:4.35E-9 ID:SGTC_2739|Compound:tacrine|FD-Score:-6.22|P-value:1.26E-6 ID:SGTC_2890|Compound:9046729|FD-Score:4.72|P-value:9.58E-5 ID:SGTC_2920|Compound:7982904|FD-Score:6.65|P-value:9.34E-8 ID:SGTC_2930|Compound:9013230|FD-Score:-5.76|P-value:6.86E-6 ID:SGTC_3003|Compound:9075612|FD-Score:4.45|P-value:2.18E-4 ID:SGTC_3020|Compound:9089140|FD-Score:5.85|P-value:2.13E-6 ID:SGTC_3025|Compound:9087895|FD-Score:8.38|P-value:2.97E-11 ID:SGTC_3080|Compound:9117754|FD-Score:5.76|P-value:2.95E-6 ID:SGTC_3081|Compound:9117243|FD-Score:-5.49|P-value:1.74E-5 ID:SGTC_3178|Compound:9107506|FD-Score:4.66|P-value:1.16E-4 ID:SGTC_3271|Compound:9137798|FD-Score:5.38|P-value:1.14E-5 ID:SGTC_3323|Compound:9138564|FD-Score:5.71|P-value:3.62E-6 ID:SGTC_3325|Compound:9138760|FD-Score:4.44|P-value:2.24E-4 ID:SGTC_3355|Compound:9151058|FD-Score:6.16|P-value:6.53E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.52|P-value:3.44E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:-4.28|P-value:6.60E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-4.17|P-value:9.03E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.73|P-value:9.53E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.25|P-value:3.80E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:7.26|P-value:6.53E-9 ID:SGTC_203|Compound:k066-0004|FD-Score:4.19|P-value:4.48E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.08|P-value:6.07E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.64|P-value:1.24E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:4.30|P-value:3.35E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:4.02|P-value:7.26E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.82|P-value:7.03E-5 ID:SGTC_486|Compound:niguldipine|FD-Score:3.94|P-value:8.92E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:-4.93|P-value:1.03E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.71|P-value:3.58E-6 ID:SGTC_516|Compound:3992-2719|FD-Score:6.64|P-value:9.70E-8 ID:SGTC_539|Compound:4859-0462|FD-Score:10.50|P-value:1.21E-16 ID:SGTC_586|Compound:0957-0265|FD-Score:8.15|P-value:9.45E-11 ID:SGTC_673|Compound:1082-0474|FD-Score:9.95|P-value:4.25E-15 ID:SGTC_685|Compound:1278-0033|FD-Score:-4.48|P-value:3.86E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.76|P-value:8.53E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.97|P-value:8.31E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.27|P-value:3.64E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.75|P-value:6.74E-10 ID:SGTC_802|Compound:4112-3352|FD-Score:4.58|P-value:1.47E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.42|P-value:2.36E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-5.51|P-value:1.59E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:6.89|P-value:3.32E-8 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-5.27|P-value:3.60E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.03|P-value:6.92E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:4.79|P-value:7.87E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.18|P-value:6.21E-7 ID:SGTC_1229|Compound:0139-0193|FD-Score:5.35|P-value:1.27E-5 ID:SGTC_1471|Compound:k673-0312|FD-Score:4.09|P-value:5.93E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-6.57|P-value:3.28E-7 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-7.53|P-value:5.66E-9 ID:SGTC_1706|Compound:st031321|FD-Score:-4.54|P-value:3.27E-4 ID:SGTC_1711|Compound:st032263|FD-Score:4.14|P-value:5.24E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.94|P-value:8.81E-4 ID:SGTC_1814|Compound:st052110|FD-Score:5.35|P-value:1.28E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.98|P-value:8.05E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.89|P-value:5.78E-5 ID:SGTC_1915|Compound:st067105|FD-Score:18.90|P-value:4.02E-49 ID:SGTC_1930|Compound:st074634|FD-Score:7.58|P-value:1.52E-9 ID:SGTC_2057|Compound:5236571|FD-Score:5.21|P-value:2.05E-5 ID:SGTC_2086|Compound:5274770|FD-Score:4.10|P-value:5.81E-4 ID:SGTC_2156|Compound:5649887|FD-Score:4.34|P-value:2.99E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.93|P-value:5.06E-5 ID:SGTC_2306|Compound:7482397|FD-Score:4.53|P-value:1.72E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-4.16|P-value:9.16E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-4.16|P-value:9.08E-4 ID:SGTC_2393|Compound:9031399|FD-Score:6.50|P-value:1.74E-7 ID:SGTC_2396|Compound:5342950|FD-Score:5.30|P-value:1.51E-5 ID:SGTC_2411|Compound:st077133|FD-Score:10.90|P-value:1.18E-17 ID:SGTC_2477|Compound:5967686|FD-Score:3.96|P-value:8.36E-4 ID:SGTC_2480|Compound:5767542|FD-Score:5.44|P-value:9.38E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.16|P-value:4.86E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:7.25|P-value:6.78E-9 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.81|P-value:7.41E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:7.53|P-value:1.92E-9 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.50|P-value:3.65E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:6.20|P-value:5.66E-7 ID:SGTC_2738|Compound:aclarubicin|FD-Score:7.35|P-value:4.35E-9 ID:SGTC_2739|Compound:tacrine|FD-Score:-6.22|P-value:1.26E-6 ID:SGTC_2890|Compound:9046729|FD-Score:4.72|P-value:9.58E-5 ID:SGTC_2920|Compound:7982904|FD-Score:6.65|P-value:9.34E-8 ID:SGTC_2930|Compound:9013230|FD-Score:-5.76|P-value:6.86E-6 ID:SGTC_3003|Compound:9075612|FD-Score:4.45|P-value:2.18E-4 ID:SGTC_3020|Compound:9089140|FD-Score:5.85|P-value:2.13E-6 ID:SGTC_3025|Compound:9087895|FD-Score:8.38|P-value:2.97E-11 ID:SGTC_3080|Compound:9117754|FD-Score:5.76|P-value:2.95E-6 ID:SGTC_3081|Compound:9117243|FD-Score:-5.49|P-value:1.74E-5 ID:SGTC_3178|Compound:9107506|FD-Score:4.66|P-value:1.16E-4 ID:SGTC_3271|Compound:9137798|FD-Score:5.38|P-value:1.14E-5 ID:SGTC_3323|Compound:9138564|FD-Score:5.71|P-value:3.62E-6 ID:SGTC_3325|Compound:9138760|FD-Score:4.44|P-value:2.24E-4 ID:SGTC_3355|Compound:9151058|FD-Score:6.16|P-value:6.53E-7

Top fitness defect scores for YDL152W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1915 st067105 18.90 30.6 µM 4.02E-49 RNA pol III & RNase P/MRP 3 2.58E-80 4.87
2 SGTC_2411 st077133 10.90 39.9 µM 1.18E-17 RNA pol III & RNase P/MRP 7 7.06E-28 2.51
3 SGTC_539 4859-0462 10.50 2.5 µM 1.21E-16 RNA pol III & RNase P/MRP 3 3.30E-26 0.60
4 SGTC_673 1082-0474 9.95 110.0 µM 4.25E-15 RSC complex & mRNA processing 11 1.20E-23 0.20
5 SGTC_3025 9087895 8.38 49.5 µM 2.97E-11 PDR1 1 2.68E-17 3.69
6 SGTC_586 0957-0265 8.15 8.2 µM 9.45E-11 cell wall 14 1.81E-16 0.05
7 SGTC_800 3448-7362 7.75 155.0 µM 6.74E-10 translation 13 4.58E-15 0.09
8 SGTC_1930 st074634 7.58 34.3 µM 1.52E-9 RNA pol III & RNase P/MRP 6 1.74E-14 0.57
9 SGTC_2544 sphondin 7.53 68.5 µM 1.92E-9 RNA pol III & RNase P/MRP 13 2.56E-14 0.17
10 SGTC_2738 aclarubicin 7.35 5.5 µM 4.35E-9 RNA pol III & RNase P/MRP 4 9.77E-14 2.96
11 SGTC_138 0850-0259 7.26 40.9 µM 6.53E-9 cell wall 21 1.90E-13 0.28
12 SGTC_2522 biochanin a 7.25 4.9 µM 6.78E-9 RNA pol III & RNase P/MRP 4 2.03E-13 1.68
13 SGTC_1064 honokiol 6.89 6.8 µM 3.32E-8 2 2.74E-12 1.17
14 SGTC_2920 7982904 6.65 15.8 µM 9.34E-8 1 1.48E-11 0.67
15 SGTC_516 3992-2719 6.64 87.3 µM 9.70E-8 2 1.58E-11 2.27
16 SGTC_2393 9031399 6.50 185.9 µM 1.74E-7 RNA processing & uracil transport 2 4.11E-11 0.84
17 SGTC_2612 dictamnine 6.20 15.5 µM 5.66E-7 RNA pol III & RNase P/MRP 17 2.81E-10 0.20
18 SGTC_1133 3473-0247 6.18 50.0 µM 6.21E-7 RSC complex & mRNA processing 20 3.27E-10 0.07
19 SGTC_3355 9151058 6.16 44.0 µM 6.53E-7 RNA processing & uracil transport 1 3.56E-10 1.77
20 SGTC_3020 9089140 5.85 49.5 µM 2.13E-6 1 2.43E-9 0.55

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.457 3.20E-173 YDL150W RPC53 het RNA polymerase III subunit C53
0.391 8.08E-123 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.343 2.68E-93 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.241 1.84E-45 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.208 5.39E-34 YPR190C RPC82 het RNA polymerase III subunit C82
0.204 5.17E-33 YKL144C RPC25 het RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p
0.199 1.92E-31 YJL011C RPC17 het RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress
0.197 1.45E-30 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.194 1.06E-29 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.192 4.28E-29 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.177 4.37E-25 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.176 1.06E-24 YBR154C RPB5 het RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.174 3.27E-24 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.167 2.02E-22 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.164 9.94E-22 YNL248C RPA49 hom RNA polymerase I subunit A49