HIPHOP chemogenomics database
YDL152W_d 
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YDL152W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.457 | 3.20E-173 | YDL150W | RPC53 | het | RNA polymerase III subunit C53 |
| 0.391 | 8.08E-123 | YOR116C | RPO31 | het | RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 |
| 0.343 | 2.68E-93 | YOR207C | RET1 | het | Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs |
| 0.241 | 1.84E-45 | YNL221C | POP1 | het | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P |
| 0.208 | 5.39E-34 | YPR190C | RPC82 | het | RNA polymerase III subunit C82 |
| 0.204 | 5.17E-33 | YKL144C | RPC25 | het | RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p |
| 0.199 | 1.92E-31 | YJL011C | RPC17 | het | RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress |
| 0.197 | 1.45E-30 | YOR260W | GCD1 | het | Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
| 0.194 | 1.06E-29 | YDR225W | HTA1 | hom | Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p |
| 0.192 | 4.28E-29 | YGR083C | GCD2 | het | Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
| 0.177 | 4.37E-25 | YBR257W | POP4 | het | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P |
| 0.176 | 1.06E-24 | YBR154C | RPB5 | het | RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation |
| 0.174 | 3.27E-24 | YLR291C | GCD7 | het | Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
| 0.167 | 2.02E-22 | YPR104C | FHL1 | het | Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants |
| 0.164 | 9.94E-22 | YNL248C | RPA49 | hom | RNA polymerase I subunit A49 |