YDL153C / SAS10

Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL153C / SAS10

Click on Significant Values for Screen Details ID:SGTC_107|Compound:0358-0022|FD-Score:4.80|P-value:3.76E-7 ID:SGTC_109|Compound:0132-0036|FD-Score:3.01|P-value:9.53E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-12.20|P-value:8.57E-37 ID:SGTC_119|Compound:0121-0043|FD-Score:4.40|P-value:2.98E-6 ID:SGTC_123|Compound:0083-0120|FD-Score:-4.09|P-value:1.25E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:3.02|P-value:9.43E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.25|P-value:4.08E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.38|P-value:2.49E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.23|P-value:3.63E-8 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.22|P-value:4.59E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.14|P-value:6.16E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.51|P-value:1.52E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.45|P-value:1.90E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.78|P-value:4.92E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.27|P-value:3.76E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.16|P-value:5.61E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.15|P-value:5.94E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:4.33|P-value:4.18E-6 ID:SGTC_855|Compound:0428-0020|FD-Score:3.47|P-value:1.72E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.11|P-value:6.66E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.41|P-value:2.20E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.16|P-value:5.63E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:-3.09|P-value:7.42E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.02|P-value:9.35E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:-3.04|P-value:8.66E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.08|P-value:7.63E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.59|P-value:1.08E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.00|P-value:9.84E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.02|P-value:9.18E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.13|P-value:6.27E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.82|P-value:3.35E-7 ID:SGTC_1931|Compound:st074438|FD-Score:3.95|P-value:2.34E-5 ID:SGTC_2068|Compound:5226020|FD-Score:4.04|P-value:1.56E-5 ID:SGTC_2109|Compound:5483026|FD-Score:-3.24|P-value:4.27E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-4.06|P-value:1.42E-5 ID:SGTC_2376|Compound:9072922|FD-Score:4.06|P-value:1.43E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.18|P-value:8.29E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.37|P-value:3.35E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:-5.39|P-value:1.42E-8 ID:SGTC_2602|Compound:kawain|FD-Score:6.06|P-value:2.11E-10 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.53|P-value:1.39E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.82|P-value:4.19E-5 ID:SGTC_2850|Compound:9015429|FD-Score:-3.35|P-value:2.78E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.43|P-value:2.03E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.22|P-value:6.89E-6 ID:SGTC_2860|Compound:9025725|FD-Score:3.39|P-value:2.43E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-3.88|P-value:3.18E-5 ID:SGTC_2900|Compound:5328528|FD-Score:3.80|P-value:4.56E-5 ID:SGTC_2926|Compound:9010726|FD-Score:4.06|P-value:1.45E-5 ID:SGTC_2988|Compound:9073640|FD-Score:7.72|P-value:9.49E-16 ID:SGTC_2996|Compound:9066192|FD-Score:-3.22|P-value:4.57E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.63|P-value:9.17E-5 ID:SGTC_3045|Compound:9092950|FD-Score:3.26|P-value:3.99E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.33|P-value:4.07E-6 ID:SGTC_3329|Compound:9141233|FD-Score:3.58|P-value:1.13E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:4.80|P-value:3.76E-7 ID:SGTC_109|Compound:0132-0036|FD-Score:3.01|P-value:9.53E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-12.20|P-value:8.57E-37 ID:SGTC_119|Compound:0121-0043|FD-Score:4.40|P-value:2.98E-6 ID:SGTC_123|Compound:0083-0120|FD-Score:-4.09|P-value:1.25E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:3.02|P-value:9.43E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.25|P-value:4.08E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.38|P-value:2.49E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.23|P-value:3.63E-8 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.22|P-value:4.59E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.14|P-value:6.16E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.51|P-value:1.52E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.45|P-value:1.90E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.78|P-value:4.92E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.27|P-value:3.76E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.16|P-value:5.61E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.15|P-value:5.94E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:4.33|P-value:4.18E-6 ID:SGTC_855|Compound:0428-0020|FD-Score:3.47|P-value:1.72E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.11|P-value:6.66E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.41|P-value:2.20E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.16|P-value:5.63E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:-3.09|P-value:7.42E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.02|P-value:9.35E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:-3.04|P-value:8.66E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.08|P-value:7.63E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.59|P-value:1.08E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.00|P-value:9.84E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.02|P-value:9.18E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.13|P-value:6.27E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.82|P-value:3.35E-7 ID:SGTC_1931|Compound:st074438|FD-Score:3.95|P-value:2.34E-5 ID:SGTC_2068|Compound:5226020|FD-Score:4.04|P-value:1.56E-5 ID:SGTC_2109|Compound:5483026|FD-Score:-3.24|P-value:4.27E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-4.06|P-value:1.42E-5 ID:SGTC_2376|Compound:9072922|FD-Score:4.06|P-value:1.43E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.18|P-value:8.29E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.37|P-value:3.35E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:-5.39|P-value:1.42E-8 ID:SGTC_2602|Compound:kawain|FD-Score:6.06|P-value:2.11E-10 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.53|P-value:1.39E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.82|P-value:4.19E-5 ID:SGTC_2850|Compound:9015429|FD-Score:-3.35|P-value:2.78E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.43|P-value:2.03E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.22|P-value:6.89E-6 ID:SGTC_2860|Compound:9025725|FD-Score:3.39|P-value:2.43E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-3.88|P-value:3.18E-5 ID:SGTC_2900|Compound:5328528|FD-Score:3.80|P-value:4.56E-5 ID:SGTC_2926|Compound:9010726|FD-Score:4.06|P-value:1.45E-5 ID:SGTC_2988|Compound:9073640|FD-Score:7.72|P-value:9.49E-16 ID:SGTC_2996|Compound:9066192|FD-Score:-3.22|P-value:4.57E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.63|P-value:9.17E-5 ID:SGTC_3045|Compound:9092950|FD-Score:3.26|P-value:3.99E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.33|P-value:4.07E-6 ID:SGTC_3329|Compound:9141233|FD-Score:3.58|P-value:1.13E-4

Top fitness defect scores for YDL153C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2988 9073640 7.72 71.4 µM 9.49E-16 1 6.03E-15 1.43
2 SGTC_2602 kawain 6.06 100.0 µM 2.11E-10 1 6.69E-10 0.83
3 SGTC_1919 st067113 4.82 52.3 µM 3.35E-7 TSC3-RPN4 5 7.02E-7 0.35
4 SGTC_107 0358-0022 4.80 2.7 µM 3.76E-7 SWF1 & branched chain AA biosynthesis 4 7.83E-7 0.94
5 SGTC_119 0121-0043 4.40 24.8 µM 2.98E-6 mitochondrial stress 14 5.53E-6 0.10
6 SGTC_2595 hexamethylquercetagetin 4.37 100.0 µM 3.35E-6 3 6.18E-6 0.39
7 SGTC_3137 9097352 4.33 49.5 µM 4.07E-6 3 7.43E-6 0.07
8 SGTC_728 3030-5151 4.33 22.5 µM 4.18E-6 1 7.61E-6 0.44
9 SGTC_2594 a-mangostin 4.18 100.0 µM 8.29E-6 4 1.45E-5 0.01
10 SGTC_2376 9072922 4.06 81.3 µM 1.43E-5 3 2.44E-5 0.20
11 SGTC_2926 9010726 4.06 65.2 µM 1.45E-5 5 2.46E-5 0.08
12 SGTC_2068 5226020 4.04 147.0 µM 1.56E-5 6 2.64E-5 0.21
13 SGTC_1931 st074438 3.95 57.1 µM 2.34E-5 12 3.88E-5 0.09
14 SGTC_2765 myclobutanil 3.82 7.7 µM 4.19E-5 azole & statin 10 6.72E-5 0.16
15 SGTC_2900 5328528 3.80 85.3 µM 4.56E-5 Golgi 6 7.28E-5 0.10
16 SGTC_512 prima-1 3.78 270.0 µM 4.92E-5 DNA intercalators 15 7.83E-5 0.09
17 SGTC_3026 9090633 3.63 49.5 µM 9.17E-5 8 1.41E-4 0.05
18 SGTC_1594 piperine 3.59 70.1 µM 1.08E-4 4 1.64E-4 0.44
19 SGTC_3329 9141233 3.58 27.6 µM 1.13E-4 5 1.71E-4 0.16
20 SGTC_2759 disulfiram 3.53 3.4 µM 1.39E-4 28 2.09E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.199 2.08E-31 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.193 2.10E-29 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.167 2.95E-22 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.163 2.78E-21 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.159 1.88E-20 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.151 1.31E-18 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.139 6.47E-16 YNL163C RIA1 het Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.134 7.11E-15 YJL174W KRE9 het Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.134 7.50E-15 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.127 1.44E-13 YBL084C CDC27 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.119 4.03E-12 YKL033W TTI1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies
0.119 4.16E-12 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.117 8.95E-12 YLL013C PUF3 hom Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
0.116 1.61E-11 YIR011C STS1 het Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
0.115 2.06E-11 YJL061W NUP82 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)