YDL156W / CMR1

DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL156W / CMR1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.62|P-value:2.57E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-4.28|P-value:1.68E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.99|P-value:6.26E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.30|P-value:7.77E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.64|P-value:2.41E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.58|P-value:2.64E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.79|P-value:1.36E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:-4.47|P-value:7.49E-6 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.44|P-value:4.79E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.46|P-value:4.51E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.39|P-value:1.24E-5 ID:SGTC_1626|Compound:st003712|FD-Score:4.98|P-value:8.33E-7 ID:SGTC_1632|Compound:st005650|FD-Score:4.20|P-value:2.74E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.70|P-value:1.94E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.27|P-value:8.48E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.85|P-value:1.08E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:6.09|P-value:2.34E-9 ID:SGTC_1881|Compound:5652484|FD-Score:-5.36|P-value:1.05E-7 ID:SGTC_2018|Compound:5133068|FD-Score:3.43|P-value:5.02E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.23|P-value:8.77E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.56|P-value:3.14E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.20|P-value:2.71E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.91|P-value:8.70E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-6.77|P-value:2.85E-11 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.73|P-value:1.69E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.38|P-value:5.23E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.68|P-value:2.03E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.22|P-value:8.95E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.26|P-value:8.90E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.60|P-value:2.79E-4 ID:SGTC_3175|Compound:9106517|FD-Score:5.82|P-value:1.07E-8 ID:SGTC_3184|Compound:9108758|FD-Score:3.61|P-value:2.63E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-5.17|P-value:2.83E-7 ID:SGTC_3310|Compound:9130229|FD-Score:4.44|P-value:9.99E-6 ID:SGTC_3334|Compound:9142812|FD-Score:4.57|P-value:5.70E-6 ID:SGTC_3338|Compound:9144300|FD-Score:-3.37|P-value:5.48E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.87|P-value:1.03E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.62|P-value:2.57E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-4.28|P-value:1.68E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.99|P-value:6.26E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.30|P-value:7.77E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.64|P-value:2.41E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.58|P-value:2.64E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.79|P-value:1.36E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:-4.47|P-value:7.49E-6 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.44|P-value:4.79E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.46|P-value:4.51E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.39|P-value:1.24E-5 ID:SGTC_1626|Compound:st003712|FD-Score:4.98|P-value:8.33E-7 ID:SGTC_1632|Compound:st005650|FD-Score:4.20|P-value:2.74E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.70|P-value:1.94E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.27|P-value:8.48E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.85|P-value:1.08E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:6.09|P-value:2.34E-9 ID:SGTC_1881|Compound:5652484|FD-Score:-5.36|P-value:1.05E-7 ID:SGTC_2018|Compound:5133068|FD-Score:3.43|P-value:5.02E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.23|P-value:8.77E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.56|P-value:3.14E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.20|P-value:2.71E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.91|P-value:8.70E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-6.77|P-value:2.85E-11 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.73|P-value:1.69E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.38|P-value:5.23E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.68|P-value:2.03E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.22|P-value:8.95E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.26|P-value:8.90E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.60|P-value:2.79E-4 ID:SGTC_3175|Compound:9106517|FD-Score:5.82|P-value:1.07E-8 ID:SGTC_3184|Compound:9108758|FD-Score:3.61|P-value:2.63E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-5.17|P-value:2.83E-7 ID:SGTC_3310|Compound:9130229|FD-Score:4.44|P-value:9.99E-6 ID:SGTC_3334|Compound:9142812|FD-Score:4.57|P-value:5.70E-6 ID:SGTC_3338|Compound:9144300|FD-Score:-3.37|P-value:5.48E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.87|P-value:1.03E-4

Top fitness defect scores for YDL156W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1878 temozolomide 6.09 1.0 mM 2.34E-9 1 5.58E-10
2 SGTC_3175 9106517 5.82 49.5 µM 1.07E-8 iron homeostasis 3 2.87E-9
3 SGTC_1626 st003712 4.98 1.8 µM 8.33E-7 11 3.11E-7
4 SGTC_3334 9142812 4.57 21.9 µM 5.70E-6 18 2.46E-6
5 SGTC_3310 9130229 4.44 44.1 µM 9.99E-6 Golgi 14 4.49E-6
6 SGTC_1206 3978-0017 4.39 132.0 µM 1.24E-5 ERG2 22 5.70E-6
7 SGTC_2349 9023730 4.20 187.1 µM 2.71E-5 18 1.32E-5
8 SGTC_1632 st005650 4.20 90.0 µM 2.74E-5 23 1.33E-5
9 SGTC_143 4032-1194 3.99 15.7 µM 6.26E-5 64 3.24E-5
10 SGTC_2350 9023895 3.91 38.9 µM 8.70E-5 ergosterol biosynthesis 30 4.61E-5
11 SGTC_3348 9149464 3.87 3.5 µM 1.03E-4 14 5.53E-5
12 SGTC_1863 st057641 3.85 20.1 µM 1.08E-4 15 5.84E-5
13 SGTC_536 3852-0578 3.79 10.6 µM 1.36E-4 29 7.47E-5
14 SGTC_2553 4-methylesculetin 3.73 85.1 µM 1.69E-4 28 9.43E-5
15 SGTC_1718 roemerine 3.70 11.9 µM 1.94E-4 redox potentiating 67 1.09E-4
16 SGTC_2687 chenodiol 3.68 100.0 µM 2.03E-4 29 1.15E-4
17 SGTC_437 s-farnesyl-l-cysteine methyl ester 3.64 6.7 µM 2.41E-4 17 1.38E-4
18 SGTC_20 0481-0013 3.62 4.9 µM 2.57E-4 34 1.48E-4
19 SGTC_3184 9108758 3.61 49.5 µM 2.63E-4 10 1.51E-4
20 SGTC_3139 9095020 3.60 49.5 µM 2.79E-4 14 1.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.71E-9 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.098 1.17E-8 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.093 8.12E-8 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.086 6.82E-7 YIL005W EPS1 hom ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family
0.085 7.86E-7 YMR232W FUS2 hom Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating
0.085 8.22E-7 YJL119C_d YJL119C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.40E-6 YGR051C_d YGR051C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
0.079 4.87E-6 YJR149W_p YJR149W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.078 5.31E-6 YDR177W UBC1 het Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress
0.078 6.41E-6 YAL034C-B_d YAL034C-B_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.075 1.21E-5 YJR017C ESS1 het Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
0.074 1.62E-5 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.074 1.63E-5 YIL141W_d YIL141W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.31E-5 YKL147C_d YKL147C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
0.073 2.36E-5 YML042W CAT2 hom Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes