YDL159W-A_p

Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL159W-A / YDL159W-A

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.73|P-value:3.20E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:-2.91|P-value:8.02E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.85|P-value:1.53E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.43|P-value:1.20E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.81|P-value:2.22E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.35|P-value:1.72E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:-3.19|P-value:2.69E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.74|P-value:2.57E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.06|P-value:3.96E-11 ID:SGTC_277|Compound:nystatin|FD-Score:3.11|P-value:4.35E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.85|P-value:1.89E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:4.45|P-value:9.04E-7 ID:SGTC_293|Compound:4049-0273|FD-Score:-2.89|P-value:8.54E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.43|P-value:1.23E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:6.37|P-value:4.15E-12 ID:SGTC_345|Compound:1362-0200|FD-Score:3.26|P-value:2.47E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.06|P-value:5.40E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.20|P-value:2.64E-4 ID:SGTC_442|Compound:cape|FD-Score:4.17|P-value:3.94E-6 ID:SGTC_444|Compound:curcumin|FD-Score:3.86|P-value:1.78E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-2.94|P-value:7.04E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.42|P-value:1.24E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.93|P-value:6.27E-8 ID:SGTC_526|Compound:4469-0568|FD-Score:3.09|P-value:4.85E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.13|P-value:3.50E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.61|P-value:3.80E-7 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.01|P-value:6.40E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.18|P-value:3.33E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-2.94|P-value:7.02E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.96|P-value:1.09E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.30|P-value:2.09E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:4.16|P-value:4.21E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:2.90|P-value:9.85E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:2.91|P-value:9.23E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.48|P-value:9.93E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:3.77|P-value:2.66E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.12|P-value:3.58E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.03|P-value:5.13E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.00|P-value:6.80E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.37|P-value:1.28E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.84|P-value:2.00E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.32|P-value:1.58E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:4.38|P-value:1.34E-6 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.31|P-value:1.98E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.16|P-value:3.66E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.03|P-value:6.09E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.67|P-value:4.35E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.04|P-value:5.81E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.36|P-value:1.62E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-2.87|P-value:9.25E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.18|P-value:2.83E-4 ID:SGTC_1987|Compound:st072290|FD-Score:8.42|P-value:7.23E-20 ID:SGTC_1990|Compound:st072050|FD-Score:3.26|P-value:2.41E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-2.95|P-value:6.85E-4 ID:SGTC_1996|Compound:st072960|FD-Score:4.25|P-value:2.69E-6 ID:SGTC_2034|Compound:5197015|FD-Score:4.31|P-value:1.97E-6 ID:SGTC_2045|Compound:5106652|FD-Score:3.43|P-value:1.22E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-2.95|P-value:6.94E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.66|P-value:4.46E-5 ID:SGTC_2271|Compound:7849410|FD-Score:2.91|P-value:9.19E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-4.86|P-value:7.29E-8 ID:SGTC_2326|Compound:6164455|FD-Score:4.19|P-value:3.55E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.23|P-value:2.79E-4 ID:SGTC_2334|Compound:9017922|FD-Score:5.48|P-value:2.14E-9 ID:SGTC_2353|Compound:9059630|FD-Score:3.64|P-value:4.98E-5 ID:SGTC_2486|Compound:5283202|FD-Score:4.74|P-value:1.88E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:2.96|P-value:7.88E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.18|P-value:3.34E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.60|P-value:5.93E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.79|P-value:1.38E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:6.30|P-value:7.05E-12 ID:SGTC_2645|Compound:abamectin|FD-Score:3.50|P-value:9.06E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:5.43|P-value:2.84E-9 ID:SGTC_2651|Compound:1327-0036|FD-Score:-2.91|P-value:7.97E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.37|P-value:1.59E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.01|P-value:6.55E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.33|P-value:1.51E-4 ID:SGTC_2818|Compound:7996756|FD-Score:4.64|P-value:3.29E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-2.91|P-value:8.00E-4 ID:SGTC_2851|Compound:9015922|FD-Score:2.98|P-value:7.22E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.17|P-value:3.23E-6 ID:SGTC_2963|Compound:9082507|FD-Score:-2.96|P-value:6.68E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.82|P-value:1.74E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.41|P-value:1.07E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.04|P-value:5.72E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.40|P-value:1.38E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.18|P-value:3.35E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.73|P-value:3.20E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:-2.91|P-value:8.02E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.85|P-value:1.53E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.43|P-value:1.20E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.81|P-value:2.22E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.35|P-value:1.72E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:-3.19|P-value:2.69E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.74|P-value:2.57E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.06|P-value:3.96E-11 ID:SGTC_277|Compound:nystatin|FD-Score:3.11|P-value:4.35E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.85|P-value:1.89E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:4.45|P-value:9.04E-7 ID:SGTC_293|Compound:4049-0273|FD-Score:-2.89|P-value:8.54E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.43|P-value:1.23E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:6.37|P-value:4.15E-12 ID:SGTC_345|Compound:1362-0200|FD-Score:3.26|P-value:2.47E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.06|P-value:5.40E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.20|P-value:2.64E-4 ID:SGTC_442|Compound:cape|FD-Score:4.17|P-value:3.94E-6 ID:SGTC_444|Compound:curcumin|FD-Score:3.86|P-value:1.78E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-2.94|P-value:7.04E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.42|P-value:1.24E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.93|P-value:6.27E-8 ID:SGTC_526|Compound:4469-0568|FD-Score:3.09|P-value:4.85E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.13|P-value:3.50E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.61|P-value:3.80E-7 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.01|P-value:6.40E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.18|P-value:3.33E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-2.94|P-value:7.02E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.96|P-value:1.09E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.30|P-value:2.09E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:4.16|P-value:4.21E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:2.90|P-value:9.85E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:2.91|P-value:9.23E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.48|P-value:9.93E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:3.77|P-value:2.66E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.12|P-value:3.58E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.03|P-value:5.13E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.00|P-value:6.80E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.37|P-value:1.28E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.84|P-value:2.00E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.32|P-value:1.58E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:4.38|P-value:1.34E-6 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.31|P-value:1.98E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.16|P-value:3.66E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.03|P-value:6.09E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.67|P-value:4.35E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.04|P-value:5.81E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.36|P-value:1.62E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-2.87|P-value:9.25E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.18|P-value:2.83E-4 ID:SGTC_1987|Compound:st072290|FD-Score:8.42|P-value:7.23E-20 ID:SGTC_1990|Compound:st072050|FD-Score:3.26|P-value:2.41E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-2.95|P-value:6.85E-4 ID:SGTC_1996|Compound:st072960|FD-Score:4.25|P-value:2.69E-6 ID:SGTC_2034|Compound:5197015|FD-Score:4.31|P-value:1.97E-6 ID:SGTC_2045|Compound:5106652|FD-Score:3.43|P-value:1.22E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-2.95|P-value:6.94E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.66|P-value:4.46E-5 ID:SGTC_2271|Compound:7849410|FD-Score:2.91|P-value:9.19E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-4.86|P-value:7.29E-8 ID:SGTC_2326|Compound:6164455|FD-Score:4.19|P-value:3.55E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.23|P-value:2.79E-4 ID:SGTC_2334|Compound:9017922|FD-Score:5.48|P-value:2.14E-9 ID:SGTC_2353|Compound:9059630|FD-Score:3.64|P-value:4.98E-5 ID:SGTC_2486|Compound:5283202|FD-Score:4.74|P-value:1.88E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:2.96|P-value:7.88E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.18|P-value:3.34E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.60|P-value:5.93E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.79|P-value:1.38E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:6.30|P-value:7.05E-12 ID:SGTC_2645|Compound:abamectin|FD-Score:3.50|P-value:9.06E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:5.43|P-value:2.84E-9 ID:SGTC_2651|Compound:1327-0036|FD-Score:-2.91|P-value:7.97E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.37|P-value:1.59E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.01|P-value:6.55E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.33|P-value:1.51E-4 ID:SGTC_2818|Compound:7996756|FD-Score:4.64|P-value:3.29E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-2.91|P-value:8.00E-4 ID:SGTC_2851|Compound:9015922|FD-Score:2.98|P-value:7.22E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.17|P-value:3.23E-6 ID:SGTC_2963|Compound:9082507|FD-Score:-2.96|P-value:6.68E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.82|P-value:1.74E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.41|P-value:1.07E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.04|P-value:5.72E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.40|P-value:1.38E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.18|P-value:3.35E-4

Top fitness defect scores for YDL159W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1987 st072290 8.42 61.9 µM 7.23E-20 1 1.83E-17
2 SGTC_304 1310-0298 6.37 97.0 µM 4.15E-12 cell wall 15 9.66E-11
3 SGTC_2627 acetyl isogambogic acid 6.30 100.0 µM 7.05E-12 TSC3-RPN4 11 1.53E-10
4 SGTC_275 trichlorophene 6.06 5.7 µM 3.96E-11 mitochondrial stress 115 6.85E-10
5 SGTC_2334 9017922 5.48 200.0 µM 2.14E-9 5 2.18E-8
6 SGTC_2648 atorvastatin 5.43 78.7 µM 2.84E-9 azole & statin 12 2.79E-8
7 SGTC_504 lovastatin 4.93 124.0 µM 6.27E-8 6 4.12E-7
8 SGTC_2610 ononetin 4.79 44.2 µM 1.38E-7 19 8.17E-7
9 SGTC_2486 5283202 4.74 22.4 µM 1.88E-7 26 1.07E-6
10 SGTC_2818 7996756 4.64 13.0 µM 3.29E-7 10 1.74E-6
11 SGTC_557 1315-0110 4.61 16.2 µM 3.80E-7 Golgi 11 1.98E-6
12 SGTC_288 1315-0019 4.45 35.1 µM 9.04E-7 RSC & ERG11 13 4.21E-6
13 SGTC_1396 3511-0007 4.38 98.6 µM 1.34E-6 mitochondrial processes 9 5.91E-6
14 SGTC_2034 5197015 4.31 53.1 µM 1.97E-6 SWF1 & branched chain AA biosynthesis 17 8.29E-6
15 SGTC_1996 st072960 4.25 66.8 µM 2.69E-6 10 1.09E-5
16 SGTC_2326 6164455 4.19 177.6 µM 3.55E-6 mitochondrial processes 16 1.38E-5
17 SGTC_442 cape 4.17 100.0 µM 3.94E-6 10 1.52E-5
18 SGTC_781 4335-2806 4.16 94.4 µM 4.21E-6 13 1.61E-5
19 SGTC_746 1095-0025 3.96 46.6 µM 1.09E-5 RSC & ERG11 14 3.69E-5
20 SGTC_444 curcumin 3.86 90.4 µM 1.78E-5 iron homeostasis 30 5.65E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.73E-16 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.138 1.06E-15 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.127 1.89E-13 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.124 5.49E-13 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.121 1.66E-12 YBL080C PET112 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog
0.112 7.79E-11 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.112 9.45E-11 YGR174C CBP4 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex
0.111 1.32E-10 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.107 5.17E-10 YOR200W_d YOR200W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c
0.106 7.05E-10 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.106 8.78E-10 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.105 1.01E-9 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.104 1.61E-9 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.103 2.28E-9 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.102 3.83E-9 YJL180C ATP12 hom Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency