YDL160C / DHH1

Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL160C / DHH1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:6.32|P-value:1.51E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.92|P-value:1.06E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:5.61|P-value:4.33E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:3.68|P-value:6.40E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.66|P-value:2.20E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:7.74|P-value:5.77E-12 ID:SGTC_187|Compound:1488-2104|FD-Score:6.16|P-value:3.36E-8 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:5.49|P-value:7.45E-7 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.49|P-value:4.22E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:7.12|P-value:2.14E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.27|P-value:8.10E-11 ID:SGTC_458|Compound:nppb|FD-Score:3.65|P-value:7.06E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:12.00|P-value:2.71E-26 ID:SGTC_502|Compound:l-744,832|FD-Score:5.07|P-value:4.47E-6 ID:SGTC_518|Compound:1021-0119|FD-Score:4.75|P-value:1.56E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.26|P-value:9.61E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.61|P-value:7.94E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.63|P-value:7.49E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:5.81|P-value:1.73E-7 ID:SGTC_764|Compound:1951-2361|FD-Score:3.75|P-value:5.17E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.65|P-value:7.02E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.33|P-value:1.50E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:4.19|P-value:1.19E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.26|P-value:9.55E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:7.32|P-value:7.03E-11 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.52|P-value:9.66E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.67|P-value:2.14E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.88|P-value:3.43E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.60|P-value:2.77E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.98|P-value:2.47E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:10.30|P-value:6.25E-20 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.60|P-value:7.73E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:4.79|P-value:1.38E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.48|P-value:4.32E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.78|P-value:4.36E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.65|P-value:6.99E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.42|P-value:3.77E-11 ID:SGTC_1623|Compound:st003709|FD-Score:3.93|P-value:2.87E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.62|P-value:2.63E-5 ID:SGTC_1666|Compound:st014829|FD-Score:4.90|P-value:8.92E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.66|P-value:2.24E-5 ID:SGTC_1750|Compound:st081859|FD-Score:8.94|P-value:2.18E-15 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.62|P-value:4.25E-7 ID:SGTC_1889|Compound:st059080|FD-Score:-3.67|P-value:6.11E-4 ID:SGTC_1982|Compound:st072467|FD-Score:6.01|P-value:6.84E-8 ID:SGTC_2109|Compound:5483026|FD-Score:3.84|P-value:3.80E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.84|P-value:3.86E-4 ID:SGTC_2133|Compound:5320837|FD-Score:5.88|P-value:1.30E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.92|P-value:2.97E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.89|P-value:3.27E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.91|P-value:8.30E-6 ID:SGTC_2315|Compound:7733312|FD-Score:3.60|P-value:8.13E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.77|P-value:2.14E-7 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:4.06|P-value:1.89E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:5.21|P-value:2.46E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.77|P-value:1.48E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:10.10|P-value:5.87E-19 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.48|P-value:4.30E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:5.36|P-value:1.34E-6 ID:SGTC_2820|Compound:7989630|FD-Score:3.93|P-value:2.88E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.84|P-value:3.66E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.73|P-value:5.45E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-4.09|P-value:1.61E-4 ID:SGTC_2991|Compound:9074669|FD-Score:6.12|P-value:3.99E-8 ID:SGTC_3026|Compound:9090633|FD-Score:3.67|P-value:6.60E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.58|P-value:8.67E-4 ID:SGTC_3224|Compound:9130643|FD-Score:5.13|P-value:3.50E-6 ID:SGTC_3254|Compound:9136651|FD-Score:3.72|P-value:5.64E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.99|P-value:2.36E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:6.32|P-value:1.51E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.92|P-value:1.06E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:5.61|P-value:4.33E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:3.68|P-value:6.40E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.66|P-value:2.20E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:7.74|P-value:5.77E-12 ID:SGTC_187|Compound:1488-2104|FD-Score:6.16|P-value:3.36E-8 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:5.49|P-value:7.45E-7 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.49|P-value:4.22E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:7.12|P-value:2.14E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.27|P-value:8.10E-11 ID:SGTC_458|Compound:nppb|FD-Score:3.65|P-value:7.06E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:12.00|P-value:2.71E-26 ID:SGTC_502|Compound:l-744,832|FD-Score:5.07|P-value:4.47E-6 ID:SGTC_518|Compound:1021-0119|FD-Score:4.75|P-value:1.56E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.26|P-value:9.61E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.61|P-value:7.94E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.63|P-value:7.49E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:5.81|P-value:1.73E-7 ID:SGTC_764|Compound:1951-2361|FD-Score:3.75|P-value:5.17E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.65|P-value:7.02E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.33|P-value:1.50E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:4.19|P-value:1.19E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.26|P-value:9.55E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:7.32|P-value:7.03E-11 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.52|P-value:9.66E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.67|P-value:2.14E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.88|P-value:3.43E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.60|P-value:2.77E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.98|P-value:2.47E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:10.30|P-value:6.25E-20 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.60|P-value:7.73E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:4.79|P-value:1.38E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.48|P-value:4.32E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.78|P-value:4.36E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.65|P-value:6.99E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.42|P-value:3.77E-11 ID:SGTC_1623|Compound:st003709|FD-Score:3.93|P-value:2.87E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.62|P-value:2.63E-5 ID:SGTC_1666|Compound:st014829|FD-Score:4.90|P-value:8.92E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.66|P-value:2.24E-5 ID:SGTC_1750|Compound:st081859|FD-Score:8.94|P-value:2.18E-15 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.62|P-value:4.25E-7 ID:SGTC_1889|Compound:st059080|FD-Score:-3.67|P-value:6.11E-4 ID:SGTC_1982|Compound:st072467|FD-Score:6.01|P-value:6.84E-8 ID:SGTC_2109|Compound:5483026|FD-Score:3.84|P-value:3.80E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.84|P-value:3.86E-4 ID:SGTC_2133|Compound:5320837|FD-Score:5.88|P-value:1.30E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.92|P-value:2.97E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.89|P-value:3.27E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.91|P-value:8.30E-6 ID:SGTC_2315|Compound:7733312|FD-Score:3.60|P-value:8.13E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.77|P-value:2.14E-7 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:4.06|P-value:1.89E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:5.21|P-value:2.46E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.77|P-value:1.48E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:10.10|P-value:5.87E-19 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.48|P-value:4.30E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:5.36|P-value:1.34E-6 ID:SGTC_2820|Compound:7989630|FD-Score:3.93|P-value:2.88E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.84|P-value:3.66E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.73|P-value:5.45E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-4.09|P-value:1.61E-4 ID:SGTC_2991|Compound:9074669|FD-Score:6.12|P-value:3.99E-8 ID:SGTC_3026|Compound:9090633|FD-Score:3.67|P-value:6.60E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.58|P-value:8.67E-4 ID:SGTC_3224|Compound:9130643|FD-Score:5.13|P-value:3.50E-6 ID:SGTC_3254|Compound:9136651|FD-Score:3.72|P-value:5.64E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.99|P-value:2.36E-4

Top fitness defect scores for YDL160C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_467 ro 31-8220 12.00 72.8 µM 2.71E-26 calcium & mitochondrial duress 5 1.42E-33
2 SGTC_1327 1436-0082 10.30 2.2 µM 6.25E-20 1 2.48E-25
3 SGTC_2679 rapamycin 10.10 1.0 nM 5.87E-19 25 4.51E-24
4 SGTC_1750 st081859 8.94 2.4 µM 2.18E-15 endomembrane recycling 52 1.88E-19
5 SGTC_103 0844-0104 7.74 51.8 µM 5.77E-12 ERAD & cell cycle 48 5.03E-15
6 SGTC_1597 7-benzyloxygramine 7.42 47.5 µM 3.77E-11 calcium & mitochondrial duress 29 5.69E-14
7 SGTC_956 1185-0240 7.32 191.0 µM 7.03E-11 4 1.27E-13
8 SGTC_351 caspofungin 7.12 25.0 nM 2.14E-10 cell wall 25 5.36E-13
9 SGTC_3 0833-0587 6.32 95.6 µM 1.51E-8 redox potentiating 7 1.31E-10
10 SGTC_187 1488-2104 6.16 32.7 µM 3.36E-8 calcium & mitochondrial duress 13 3.67E-10
11 SGTC_2991 9074669 6.12 71.4 µM 3.99E-8 azole & statin 22 4.59E-10
12 SGTC_1982 st072467 6.01 71.9 µM 6.84E-8 10 9.20E-10
13 SGTC_28 pentachloropyridine N-oxide 5.92 1.6 µM 1.06E-7 TSC3-RPN4 17 1.62E-9
14 SGTC_2133 5320837 5.88 200.0 µM 1.30E-7 ERG2 4 2.11E-9
15 SGTC_763 3453-1109 5.81 128.0 µM 1.73E-7 3 3.04E-9
16 SGTC_2322 7413319 5.77 38.2 µM 2.14E-7 ERAD & cell cycle 68 4.02E-9
17 SGTC_1844 rapamycin 5.62 4.0 nM 4.25E-7 96 9.68E-9
18 SGTC_58 0957-0393 5.61 9.0 µM 4.33E-7 cell wall 235 9.92E-9
19 SGTC_240 5hr heat shock (37°C) + Streptovitacin 5.49 300.0 µM 7.45E-7 heat shock/prefoldin 22 2.00E-8
20 SGTC_2743 auranofin 5.36 4.3 µM 1.34E-6 RPP1 & pyrimidine depletion 14 4.27E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.288 6.47E-65 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.267 5.59E-56 YGR285C ZUO1 hom Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
0.265 3.49E-55 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.234 4.51E-43 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.230 1.35E-41 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.212 2.31E-35 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.195 4.61E-30 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.194 1.29E-29 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.183 1.54E-26 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.180 8.81E-26 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.176 7.49E-25 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.175 1.97E-24 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.174 3.31E-24 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.174 3.50E-24 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.167 1.72E-22 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis