YDL162C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL162C / YDL162C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:8.99|P-value:4.09E-21 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.06|P-value:6.19E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.59|P-value:1.01E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.08|P-value:7.05E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.28|P-value:3.42E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.49|P-value:1.18E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.61|P-value:7.17E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:3.71|P-value:5.89E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.13|P-value:5.95E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.48|P-value:1.57E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:-2.99|P-value:8.19E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.53|P-value:1.26E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.01|P-value:7.57E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.11|P-value:5.31E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.34|P-value:2.17E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.14|P-value:5.65E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.84|P-value:3.37E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.16|P-value:5.36E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.31|P-value:3.06E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.10|P-value:6.64E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.92|P-value:2.41E-5 ID:SGTC_1923|Compound:st058458|FD-Score:-2.99|P-value:8.15E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.44|P-value:1.81E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.09|P-value:6.92E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-2.94|P-value:9.52E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.18|P-value:4.98E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.56|P-value:1.13E-4 ID:SGTC_2101|Compound:5377231|FD-Score:-2.95|P-value:9.26E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.70|P-value:6.24E-5 ID:SGTC_2416|Compound:tofa|FD-Score:4.16|P-value:7.90E-6 ID:SGTC_2450|Compound:5739737|FD-Score:3.02|P-value:8.75E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.02|P-value:8.90E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.71|P-value:6.04E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.96|P-value:2.00E-5 ID:SGTC_2956|Compound:9076196|FD-Score:3.18|P-value:4.96E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.76|P-value:4.76E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.31|P-value:2.42E-4 ID:SGTC_3158|Compound:9100007|FD-Score:4.75|P-value:3.98E-7 ID:SGTC_3205|Compound:9113483|FD-Score:-4.29|P-value:3.22E-6 ID:SGTC_3210|Compound:9128157|FD-Score:-3.07|P-value:6.09E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.82|P-value:3.74E-5 ID:SGTC_3259|Compound:9138485|FD-Score:3.12|P-value:6.16E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.24|P-value:3.99E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.99|P-value:4.09E-21 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.06|P-value:6.19E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.59|P-value:1.01E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.08|P-value:7.05E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.28|P-value:3.42E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.49|P-value:1.18E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.61|P-value:7.17E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:3.71|P-value:5.89E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.13|P-value:5.95E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.48|P-value:1.57E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:-2.99|P-value:8.19E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.53|P-value:1.26E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.01|P-value:7.57E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.11|P-value:5.31E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.34|P-value:2.17E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.14|P-value:5.65E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.84|P-value:3.37E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.16|P-value:5.36E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.31|P-value:3.06E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.10|P-value:6.64E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.92|P-value:2.41E-5 ID:SGTC_1923|Compound:st058458|FD-Score:-2.99|P-value:8.15E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.44|P-value:1.81E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.09|P-value:6.92E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-2.94|P-value:9.52E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.18|P-value:4.98E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.56|P-value:1.13E-4 ID:SGTC_2101|Compound:5377231|FD-Score:-2.95|P-value:9.26E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.70|P-value:6.24E-5 ID:SGTC_2416|Compound:tofa|FD-Score:4.16|P-value:7.90E-6 ID:SGTC_2450|Compound:5739737|FD-Score:3.02|P-value:8.75E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.02|P-value:8.90E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.71|P-value:6.04E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.96|P-value:2.00E-5 ID:SGTC_2956|Compound:9076196|FD-Score:3.18|P-value:4.96E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.76|P-value:4.76E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.31|P-value:2.42E-4 ID:SGTC_3158|Compound:9100007|FD-Score:4.75|P-value:3.98E-7 ID:SGTC_3205|Compound:9113483|FD-Score:-4.29|P-value:3.22E-6 ID:SGTC_3210|Compound:9128157|FD-Score:-3.07|P-value:6.09E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.82|P-value:3.74E-5 ID:SGTC_3259|Compound:9138485|FD-Score:3.12|P-value:6.16E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.24|P-value:3.99E-4

Top fitness defect scores for YDL162C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 8.99 9.0 µM 4.09E-21 cell wall 99 1.29E-19
2 SGTC_3158 9100007 4.75 49.5 µM 3.98E-7 9 1.00E-6
3 SGTC_2416 tofa 4.16 880.0 nM 7.90E-6 sphingolipid biosynthesis & PDR1 44 1.59E-5
4 SGTC_2665 lovastatin 3.96 100.0 µM 2.00E-5 11 3.75E-5
5 SGTC_1837 st055472 3.92 66.5 µM 2.41E-5 18 4.45E-5
6 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 3.84 85.4 µM 3.37E-5 24 6.07E-5
7 SGTC_3212 9128307 3.82 49.5 µM 3.74E-5 50 6.69E-5
8 SGTC_3082 9117008 3.76 49.5 µM 4.76E-5 19 8.37E-5
9 SGTC_849 0386-0493 3.71 241.0 µM 5.89E-5 25 1.02E-4
10 SGTC_2582 agaric acid 3.71 100.0 µM 6.04E-5 redox potentiating 342 1.04E-4
11 SGTC_2414 st077232 3.70 92.9 µM 6.24E-5 28 1.08E-4
12 SGTC_159 3970-0959 3.59 50.0 µM 1.01E-4 101 1.67E-4
13 SGTC_2100 5377183 3.56 190.0 µM 1.13E-4 60S ribosome export 17 1.86E-4
14 SGTC_1083 didemethylchlorpromazine sulfoxide 3.53 707.4 nM 1.26E-4 redox potentiating 102 2.07E-4
15 SGTC_960 1222-0186 3.48 7.7 µM 1.57E-4 48 2.54E-4
16 SGTC_1937 st074714 3.44 47.2 µM 1.81E-4 57 2.89E-4
17 SGTC_1716 st033144 3.31 30.6 µM 3.06E-4 40 4.70E-4
18 SGTC_496 calpeptin 3.28 138.0 µM 3.42E-4 38 5.21E-4
19 SGTC_3274 9138298 3.24 49.5 µM 3.99E-4 45 6.01E-4
20 SGTC_2956 9076196 3.18 2.5 µM 4.96E-4 58 7.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.287 7.99E-65 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.282 3.24E-62 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.273 2.62E-58 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.272 6.78E-58 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.250 7.01E-49 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.236 9.70E-44 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.235 3.01E-43 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.234 6.53E-43 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.228 9.21E-41 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.227 2.42E-40 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.221 2.00E-38 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.220 3.38E-38 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.220 4.21E-38 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.220 6.10E-38 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.216 7.56E-37 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex