YDL163W_d

Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL163W / YDL163W

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.13|P-value:9.36E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.16|P-value:8.57E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.28|P-value:5.60E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.67|P-value:1.66E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:4.31|P-value:8.94E-6 ID:SGTC_413|Compound:propylparaben|FD-Score:-4.07|P-value:2.35E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.32|P-value:4.36E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.39|P-value:3.82E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:6.41|P-value:8.60E-11 ID:SGTC_680|Compound:0417-1641|FD-Score:4.54|P-value:3.20E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:3.21|P-value:7.06E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.73|P-value:9.52E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.94|P-value:4.54E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-5.13|P-value:1.47E-7 ID:SGTC_837|Compound:0091-0265|FD-Score:4.83|P-value:7.66E-7 ID:SGTC_978|Compound:1416-0512|FD-Score:5.71|P-value:6.67E-9 ID:SGTC_989|Compound:1501-0895|FD-Score:3.16|P-value:8.32E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.03|P-value:3.00E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.05|P-value:2.86E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.14|P-value:1.95E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.14|P-value:9.08E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.53|P-value:2.06E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.04|P-value:2.90E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.22|P-value:6.31E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:-3.92|P-value:4.34E-5 ID:SGTC_1696|Compound:st025591|FD-Score:-3.22|P-value:6.41E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-3.17|P-value:7.39E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.28|P-value:5.10E-4 ID:SGTC_2142|Compound:5622915|FD-Score:-6.64|P-value:1.62E-11 ID:SGTC_2145|Compound:5634607|FD-Score:-4.37|P-value:6.27E-6 ID:SGTC_2149|Compound:5554786|FD-Score:-3.75|P-value:8.85E-5 ID:SGTC_2155|Compound:5570423|FD-Score:4.16|P-value:1.73E-5 ID:SGTC_2195|Compound:6536160|FD-Score:-3.57|P-value:1.78E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.71|P-value:1.03E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.86|P-value:6.17E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.87|P-value:5.88E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.10|P-value:9.64E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.85|P-value:5.82E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.23|P-value:6.64E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.19|P-value:7.55E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.42|P-value:3.10E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.24|P-value:5.81E-4 ID:SGTC_2885|Compound:9057732|FD-Score:-3.86|P-value:5.64E-5 ID:SGTC_2929|Compound:9013348|FD-Score:3.84|P-value:6.68E-5 ID:SGTC_3055|Compound:9094636|FD-Score:-3.89|P-value:4.95E-5 ID:SGTC_3194|Compound:9111903|FD-Score:-3.80|P-value:7.02E-5 ID:SGTC_3211|Compound:9128781|FD-Score:4.13|P-value:1.96E-5 ID:SGTC_3238|Compound:9133470|FD-Score:3.59|P-value:1.76E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.28|P-value:5.06E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.13|P-value:9.36E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.16|P-value:8.57E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.28|P-value:5.60E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.67|P-value:1.66E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:4.31|P-value:8.94E-6 ID:SGTC_413|Compound:propylparaben|FD-Score:-4.07|P-value:2.35E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.32|P-value:4.36E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.39|P-value:3.82E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:6.41|P-value:8.60E-11 ID:SGTC_680|Compound:0417-1641|FD-Score:4.54|P-value:3.20E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:3.21|P-value:7.06E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.73|P-value:9.52E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.94|P-value:4.54E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-5.13|P-value:1.47E-7 ID:SGTC_837|Compound:0091-0265|FD-Score:4.83|P-value:7.66E-7 ID:SGTC_978|Compound:1416-0512|FD-Score:5.71|P-value:6.67E-9 ID:SGTC_989|Compound:1501-0895|FD-Score:3.16|P-value:8.32E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.03|P-value:3.00E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.05|P-value:2.86E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.14|P-value:1.95E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.14|P-value:9.08E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.53|P-value:2.06E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.04|P-value:2.90E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.22|P-value:6.31E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:-3.92|P-value:4.34E-5 ID:SGTC_1696|Compound:st025591|FD-Score:-3.22|P-value:6.41E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-3.17|P-value:7.39E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.28|P-value:5.10E-4 ID:SGTC_2142|Compound:5622915|FD-Score:-6.64|P-value:1.62E-11 ID:SGTC_2145|Compound:5634607|FD-Score:-4.37|P-value:6.27E-6 ID:SGTC_2149|Compound:5554786|FD-Score:-3.75|P-value:8.85E-5 ID:SGTC_2155|Compound:5570423|FD-Score:4.16|P-value:1.73E-5 ID:SGTC_2195|Compound:6536160|FD-Score:-3.57|P-value:1.78E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.71|P-value:1.03E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.86|P-value:6.17E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.87|P-value:5.88E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.10|P-value:9.64E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.85|P-value:5.82E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.23|P-value:6.64E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.19|P-value:7.55E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.42|P-value:3.10E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.24|P-value:5.81E-4 ID:SGTC_2885|Compound:9057732|FD-Score:-3.86|P-value:5.64E-5 ID:SGTC_2929|Compound:9013348|FD-Score:3.84|P-value:6.68E-5 ID:SGTC_3055|Compound:9094636|FD-Score:-3.89|P-value:4.95E-5 ID:SGTC_3194|Compound:9111903|FD-Score:-3.80|P-value:7.02E-5 ID:SGTC_3211|Compound:9128781|FD-Score:4.13|P-value:1.96E-5 ID:SGTC_3238|Compound:9133470|FD-Score:3.59|P-value:1.76E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.28|P-value:5.06E-4

Top fitness defect scores for YDL163W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_532 1548-0774 6.41 215.0 µM 8.60E-11 1 7.19E-11 1.14
2 SGTC_978 1416-0512 5.71 87.4 µM 6.67E-9 redox potentiating 1 5.74E-9 0.69
3 SGTC_837 0091-0265 4.83 12.5 µM 7.66E-7 ubiquinone biosynthesis & proteasome 8 6.81E-7 0.64
4 SGTC_273 hydroxyurea 4.67 18.1 mM 1.66E-6 heme biosynthesis & mitochondrial translocase 16 1.49E-6 0.04
5 SGTC_680 0417-1641 4.54 114.0 µM 3.20E-6 RPP1 & pyrimidine depletion 5 2.88E-6 0.31
6 SGTC_359 0081-0058 4.31 15.9 µM 8.94E-6 60S ribosome export 10 8.09E-6 0.04
7 SGTC_2155 5570423 4.16 76.0 µM 1.73E-5 ergosterol biosynthesis 3 1.57E-5 0.09
8 SGTC_1082 camptothecin 4.14 424.9 nM 1.95E-5 DNA damage response 18 1.77E-5 0.26
9 SGTC_3211 9128781 4.13 49.5 µM 1.96E-5 14 1.78E-5 0.40
10 SGTC_1066 ketoconazole 4.05 628.0 nM 2.86E-5 2 2.61E-5 0.37
11 SGTC_1214 0358-0031 4.04 63.7 µM 2.90E-5 6 2.64E-5 0.03
12 SGTC_1041 0206-0046 4.03 107.0 µM 3.00E-5 6 2.74E-5 0.51
13 SGTC_706 4262-0057 3.94 46.9 µM 4.54E-5 fatty acid desaturase (OLE1) 9 4.15E-5 0.05
14 SGTC_2399 5884133 3.87 200.0 µM 5.88E-5 cell wall signaling 20 5.39E-5 0.15
15 SGTC_2376 9072922 3.86 81.3 µM 6.17E-5 4 5.65E-5 0.26
16 SGTC_2929 9013348 3.84 24.6 µM 6.68E-5 5 6.13E-5 0.24
17 SGTC_3238 9133470 3.59 49.5 µM 1.76E-4 6 1.63E-4 0.24
18 SGTC_454 lyso-paf C-16 3.39 6.7 µM 3.82E-4 7 3.55E-4 0.02
19 SGTC_253 dyclonine 3.28 31.2 µM 5.60E-4 amide catabolism 10 5.22E-4 0.10
20 SGTC_2600 tangeritin 3.23 88.0 µM 6.64E-4 10 6.20E-4 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 5.61E-14 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.094 5.07E-8 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.091 1.10E-7 YOR136W IDH2 hom Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
0.090 1.98E-7 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.086 6.18E-7 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.083 1.40E-6 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.081 2.87E-6 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.074 1.72E-5 YDR284C DPP1 hom Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
0.071 4.16E-5 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.070 5.51E-5 YJR021C REC107 hom Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation
0.069 6.77E-5 YLR142W PUT1 hom Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
0.068 8.32E-5 YHR135C YCK1 hom Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication
0.068 8.72E-5 YGR074W SMD1 het Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; protein abundance increases in response to DNA replication stress
0.067 1.07E-4 YER019W ISC1 hom Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance
0.066 1.30E-4 YHR159W_p TDA11_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele