YDL164C / CDC9

DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL164C / CDC9

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:3.64|P-value:2.79E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-2.93|P-value:5.51E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.45|P-value:4.17E-7 ID:SGTC_497|Compound:capsazepine|FD-Score:3.57|P-value:3.97E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:2.96|P-value:5.28E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:2.90|P-value:6.86E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.99|P-value:5.18E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:-5.80|P-value:5.43E-11 ID:SGTC_782|Compound:0083-0095|FD-Score:3.09|P-value:3.19E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.43|P-value:6.54E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.64|P-value:2.82E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:6.14|P-value:5.16E-12 ID:SGTC_874|Compound:0599-0792|FD-Score:4.18|P-value:1.86E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.28|P-value:1.30E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:2.82|P-value:9.27E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.99|P-value:1.62E-8 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.25|P-value:1.50E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.26|P-value:1.56E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:2.99|P-value:4.78E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.52|P-value:5.00E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.22|P-value:1.47E-6 ID:SGTC_1417|Compound:3966-0327|FD-Score:2.88|P-value:7.30E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:2.86|P-value:7.96E-4 ID:SGTC_1696|Compound:st025591|FD-Score:2.87|P-value:7.63E-4 ID:SGTC_1710|Compound:st031758|FD-Score:2.80|P-value:9.76E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-2.79|P-value:9.35E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.38|P-value:9.29E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.00|P-value:4.91E-6 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.48|P-value:6.07E-5 ID:SGTC_1891|Compound:st059073|FD-Score:3.30|P-value:1.32E-4 ID:SGTC_1903|Compound:st060211|FD-Score:2.99|P-value:4.72E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-2.94|P-value:5.34E-4 ID:SGTC_1953|Compound:st076800|FD-Score:2.86|P-value:7.78E-4 ID:SGTC_1989|Compound:st071868|FD-Score:2.83|P-value:8.87E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-4.20|P-value:1.46E-6 ID:SGTC_2018|Compound:5133068|FD-Score:-5.44|P-value:7.03E-10 ID:SGTC_2020|Compound:4017018|FD-Score:3.18|P-value:2.18E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.45|P-value:4.14E-7 ID:SGTC_2205|Compound:7238770|FD-Score:3.08|P-value:3.27E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.13|P-value:2.47E-4 ID:SGTC_2315|Compound:7733312|FD-Score:4.27|P-value:1.17E-6 ID:SGTC_2323|Compound:6148992|FD-Score:-4.20|P-value:1.47E-6 ID:SGTC_2327|Compound:6189656|FD-Score:3.19|P-value:2.09E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.95|P-value:2.16E-8 ID:SGTC_2357|Compound:9067248|FD-Score:3.20|P-value:2.01E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.61|P-value:3.23E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-3.48|P-value:5.40E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-7.36|P-value:1.41E-16 ID:SGTC_2485|Compound:5633444|FD-Score:-3.82|P-value:1.05E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:5.56|P-value:3.64E-10 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.12|P-value:2.84E-4 ID:SGTC_2798|Compound:7813637|FD-Score:11.30|P-value:3.12E-36 ID:SGTC_2802|Compound:7925815|FD-Score:4.64|P-value:1.38E-7 ID:SGTC_2809|Compound:7964133|FD-Score:2.81|P-value:9.40E-4 ID:SGTC_2917|Compound:7979103|FD-Score:2.80|P-value:9.73E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-2.80|P-value:8.86E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.02|P-value:3.80E-6 ID:SGTC_3092|Compound:9117248|FD-Score:-3.05|P-value:3.38E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.64|P-value:2.79E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-2.93|P-value:5.51E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.45|P-value:4.17E-7 ID:SGTC_497|Compound:capsazepine|FD-Score:3.57|P-value:3.97E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:2.96|P-value:5.28E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:2.90|P-value:6.86E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.99|P-value:5.18E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:-5.80|P-value:5.43E-11 ID:SGTC_782|Compound:0083-0095|FD-Score:3.09|P-value:3.19E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.43|P-value:6.54E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.64|P-value:2.82E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:6.14|P-value:5.16E-12 ID:SGTC_874|Compound:0599-0792|FD-Score:4.18|P-value:1.86E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.28|P-value:1.30E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:2.82|P-value:9.27E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.99|P-value:1.62E-8 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.25|P-value:1.50E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.26|P-value:1.56E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:2.99|P-value:4.78E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.52|P-value:5.00E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.22|P-value:1.47E-6 ID:SGTC_1417|Compound:3966-0327|FD-Score:2.88|P-value:7.30E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:2.86|P-value:7.96E-4 ID:SGTC_1696|Compound:st025591|FD-Score:2.87|P-value:7.63E-4 ID:SGTC_1710|Compound:st031758|FD-Score:2.80|P-value:9.76E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-2.79|P-value:9.35E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.38|P-value:9.29E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.00|P-value:4.91E-6 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.48|P-value:6.07E-5 ID:SGTC_1891|Compound:st059073|FD-Score:3.30|P-value:1.32E-4 ID:SGTC_1903|Compound:st060211|FD-Score:2.99|P-value:4.72E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-2.94|P-value:5.34E-4 ID:SGTC_1953|Compound:st076800|FD-Score:2.86|P-value:7.78E-4 ID:SGTC_1989|Compound:st071868|FD-Score:2.83|P-value:8.87E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-4.20|P-value:1.46E-6 ID:SGTC_2018|Compound:5133068|FD-Score:-5.44|P-value:7.03E-10 ID:SGTC_2020|Compound:4017018|FD-Score:3.18|P-value:2.18E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.45|P-value:4.14E-7 ID:SGTC_2205|Compound:7238770|FD-Score:3.08|P-value:3.27E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.13|P-value:2.47E-4 ID:SGTC_2315|Compound:7733312|FD-Score:4.27|P-value:1.17E-6 ID:SGTC_2323|Compound:6148992|FD-Score:-4.20|P-value:1.47E-6 ID:SGTC_2327|Compound:6189656|FD-Score:3.19|P-value:2.09E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.95|P-value:2.16E-8 ID:SGTC_2357|Compound:9067248|FD-Score:3.20|P-value:2.01E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.61|P-value:3.23E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-3.48|P-value:5.40E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-7.36|P-value:1.41E-16 ID:SGTC_2485|Compound:5633444|FD-Score:-3.82|P-value:1.05E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:5.56|P-value:3.64E-10 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.12|P-value:2.84E-4 ID:SGTC_2798|Compound:7813637|FD-Score:11.30|P-value:3.12E-36 ID:SGTC_2802|Compound:7925815|FD-Score:4.64|P-value:1.38E-7 ID:SGTC_2809|Compound:7964133|FD-Score:2.81|P-value:9.40E-4 ID:SGTC_2917|Compound:7979103|FD-Score:2.80|P-value:9.73E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-2.80|P-value:8.86E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.02|P-value:3.80E-6 ID:SGTC_3092|Compound:9117248|FD-Score:-3.05|P-value:3.38E-4

Top fitness defect scores for YDL164C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2798 7813637 11.30 45.5 µM 3.12E-36 1 7.51E-30 3.67
2 SGTC_868 0527-0199 6.14 213.0 µM 5.16E-12 fatty acid desaturase (OLE1) 3 4.10E-10 0.27
3 SGTC_2594 a-mangostin 5.56 100.0 µM 3.64E-10 1 1.33E-8 0.90
4 SGTC_996 3970-0799 4.99 1.8 µM 1.62E-8 13 2.97E-7 0.05
5 SGTC_2354 9060492 4.95 162.0 µM 2.16E-8 4 3.77E-7 0.42
6 SGTC_2802 7925815 4.64 54.5 µM 1.38E-7 5 1.72E-6 0.06
7 SGTC_2021 4019055 4.45 173.0 µM 4.14E-7 endomembrane recycling 29 4.24E-6 0.06
8 SGTC_423 5-fluorouracil 4.45 457.0 µM 4.17E-7 exosome 22 4.26E-6 0.10
9 SGTC_2315 7733312 4.27 200.0 µM 1.17E-6 6 9.95E-6 0.13
10 SGTC_1344 1488-0097 4.22 29.1 µM 1.47E-6 2 1.20E-5 0.27
11 SGTC_874 0599-0792 4.18 117.0 µM 1.86E-6 3 1.46E-5 0.12
12 SGTC_1871 st057448 4.00 67.3 µM 4.91E-6 7 3.22E-5 0.04
13 SGTC_718 1130-0073 3.99 349.0 µM 5.18E-6 5 3.37E-5 0.23
14 SGTC_75 0159-0059 3.64 199.0 µM 2.79E-5 fatty acid desaturase (OLE1) 13 1.35E-4 0.00
15 SGTC_866 0495-0101 3.64 262.0 µM 2.82E-5 60S ribosome export 10 1.36E-4 0.19
16 SGTC_2363 9053361 3.61 176.0 µM 3.23E-5 Golgi 12 1.52E-4 0.01
17 SGTC_497 capsazepine 3.57 133.0 µM 3.97E-5 7 1.80E-4 0.00
18 SGTC_1305 1181-0477 3.52 144.0 µM 5.00E-5 7 2.18E-4 0.02
19 SGTC_1878 temozolomide 3.48 1.0 mM 6.07E-5 5 2.55E-4 0.40
20 SGTC_1738 st035555 3.38 74.0 µM 9.29E-5 TSC3-RPN4 11 3.63E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 4.72E-20 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.141 1.75E-16 YMR130W_p YMR130W_p hom Putative protein of unknown function; YMR130W is not an essential gene
0.141 1.85E-16 YOL139C CDC33 het mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth
0.139 6.80E-16 YMR096W SNZ1 hom Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.135 4.46E-15 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.134 6.08E-15 YGR048W UFD1 het Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
0.127 1.39E-13 YHR092C HXT4 hom High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication
0.125 3.41E-13 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.115 2.94E-11 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.114 4.23E-11 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.112 9.09E-11 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.108 4.18E-10 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.106 8.21E-10 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.105 1.13E-9 YLR176C RFX1 hom Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
0.102 2.72E-9 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus