YDL165W / CDC36

Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL165W / CDC36

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:-3.72|P-value:1.30E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:6.99|P-value:6.46E-12 ID:SGTC_17|Compound:0960-0276|FD-Score:3.34|P-value:6.59E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.41|P-value:4.06E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.23|P-value:9.53E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.26|P-value:8.41E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:7.78|P-value:2.48E-14 ID:SGTC_505|Compound:gw-5074|FD-Score:3.78|P-value:1.33E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.21|P-value:9.88E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:5.24|P-value:2.08E-7 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.91|P-value:6.21E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.30|P-value:5.97E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.52|P-value:3.51E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.43|P-value:4.83E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-4.18|P-value:2.12E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.57|P-value:2.30E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.69|P-value:2.92E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.07|P-value:4.38E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.05|P-value:4.69E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:6.45|P-value:2.22E-10 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.72|P-value:2.62E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.78|P-value:1.05E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.38|P-value:5.72E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.23|P-value:9.36E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.96|P-value:6.79E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:-3.23|P-value:7.46E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.48|P-value:3.97E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.87|P-value:9.50E-5 ID:SGTC_1664|Compound:st014217|FD-Score:3.98|P-value:6.24E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-3.82|P-value:8.90E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.79|P-value:1.87E-6 ID:SGTC_1831|Compound:st055328|FD-Score:-3.47|P-value:3.31E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.27|P-value:8.15E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.19|P-value:1.96E-5 ID:SGTC_2137|Compound:5261020|FD-Score:3.77|P-value:1.41E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.49|P-value:3.83E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.39|P-value:5.49E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.26|P-value:1.85E-7 ID:SGTC_2336|Compound:9001819|FD-Score:-3.56|P-value:2.38E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.14|P-value:9.96E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.41|P-value:5.10E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.47|P-value:4.20E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.60|P-value:4.52E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.61|P-value:4.25E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.37|P-value:5.96E-4 ID:SGTC_2699|Compound:st077704|FD-Score:4.48|P-value:7.54E-6 ID:SGTC_2705|Compound:st078069|FD-Score:3.53|P-value:3.31E-4 ID:SGTC_2707|Compound:st078556|FD-Score:4.58|P-value:4.96E-6 ID:SGTC_2716|Compound:st080858|FD-Score:4.87|P-value:1.30E-6 ID:SGTC_2790|Compound:5423970|FD-Score:-4.14|P-value:2.48E-5 ID:SGTC_2867|Compound:9039098|FD-Score:4.45|P-value:8.74E-6 ID:SGTC_2896|Compound:9052656|FD-Score:3.95|P-value:7.11E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-3.89|P-value:6.76E-5 ID:SGTC_2928|Compound:9011484|FD-Score:-4.77|P-value:1.52E-6 ID:SGTC_2930|Compound:9013230|FD-Score:-3.40|P-value:4.26E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.83|P-value:1.56E-6 ID:SGTC_3202|Compound:9113761|FD-Score:3.45|P-value:4.52E-4 ID:SGTC_3219|Compound:9131112|FD-Score:5.34|P-value:1.23E-7 ID:SGTC_1|Compound:0258-0098|FD-Score:-3.72|P-value:1.30E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:6.99|P-value:6.46E-12 ID:SGTC_17|Compound:0960-0276|FD-Score:3.34|P-value:6.59E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.41|P-value:4.06E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.23|P-value:9.53E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.26|P-value:8.41E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:7.78|P-value:2.48E-14 ID:SGTC_505|Compound:gw-5074|FD-Score:3.78|P-value:1.33E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.21|P-value:9.88E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:5.24|P-value:2.08E-7 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.91|P-value:6.21E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.30|P-value:5.97E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.52|P-value:3.51E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.43|P-value:4.83E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-4.18|P-value:2.12E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.57|P-value:2.30E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.69|P-value:2.92E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.07|P-value:4.38E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.05|P-value:4.69E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:6.45|P-value:2.22E-10 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.72|P-value:2.62E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.78|P-value:1.05E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.38|P-value:5.72E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.23|P-value:9.36E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.96|P-value:6.79E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:-3.23|P-value:7.46E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.48|P-value:3.97E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.87|P-value:9.50E-5 ID:SGTC_1664|Compound:st014217|FD-Score:3.98|P-value:6.24E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-3.82|P-value:8.90E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.79|P-value:1.87E-6 ID:SGTC_1831|Compound:st055328|FD-Score:-3.47|P-value:3.31E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.27|P-value:8.15E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.19|P-value:1.96E-5 ID:SGTC_2137|Compound:5261020|FD-Score:3.77|P-value:1.41E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.49|P-value:3.83E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.39|P-value:5.49E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.26|P-value:1.85E-7 ID:SGTC_2336|Compound:9001819|FD-Score:-3.56|P-value:2.38E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.14|P-value:9.96E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.41|P-value:5.10E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.47|P-value:4.20E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.60|P-value:4.52E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.61|P-value:4.25E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.37|P-value:5.96E-4 ID:SGTC_2699|Compound:st077704|FD-Score:4.48|P-value:7.54E-6 ID:SGTC_2705|Compound:st078069|FD-Score:3.53|P-value:3.31E-4 ID:SGTC_2707|Compound:st078556|FD-Score:4.58|P-value:4.96E-6 ID:SGTC_2716|Compound:st080858|FD-Score:4.87|P-value:1.30E-6 ID:SGTC_2790|Compound:5423970|FD-Score:-4.14|P-value:2.48E-5 ID:SGTC_2867|Compound:9039098|FD-Score:4.45|P-value:8.74E-6 ID:SGTC_2896|Compound:9052656|FD-Score:3.95|P-value:7.11E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-3.89|P-value:6.76E-5 ID:SGTC_2928|Compound:9011484|FD-Score:-4.77|P-value:1.52E-6 ID:SGTC_2930|Compound:9013230|FD-Score:-3.40|P-value:4.26E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.83|P-value:1.56E-6 ID:SGTC_3202|Compound:9113761|FD-Score:3.45|P-value:4.52E-4 ID:SGTC_3219|Compound:9131112|FD-Score:5.34|P-value:1.23E-7

Top fitness defect scores for YDL165W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_227 fluconazole 7.78 33.5 µM 2.48E-14 azole & statin 23 3.66E-15 1.29
2 SGTC_15 0266-0086 6.99 27.1 µM 6.46E-12 endomembrane recycling 4 1.34E-12 0.53
3 SGTC_1203 3992-3522 6.45 103.0 µM 2.22E-10 2 5.71E-11 0.91
4 SGTC_3219 9131112 5.34 49.5 µM 1.23E-7 Golgi 8 4.66E-8 0.08
5 SGTC_2322 7413319 5.26 38.2 µM 1.85E-7 ERAD & cell cycle 16 7.20E-8 0.70
6 SGTC_604 1000-0114 5.24 314.0 µM 2.08E-7 1 8.15E-8 0.85
7 SGTC_2716 st080858 4.87 38.6 µM 1.30E-6 60S ribosome export 2 5.68E-7 1.26
8 SGTC_3142 9086498 4.83 49.5 µM 1.56E-6 iron homeostasis 32 6.90E-7 0.02
9 SGTC_1750 st081859 4.79 2.4 µM 1.87E-6 endomembrane recycling 23 8.38E-7 0.01
10 SGTC_1230 0170-0365 4.72 3.8 µM 2.62E-6 endomembrane recycling 18 1.20E-6 0.29
11 SGTC_1043 0916-0009 4.69 19.3 µM 2.92E-6 2 1.34E-6 0.06
12 SGTC_2636 apigenin dimethyl ether 4.61 100.0 µM 4.25E-6 8 2.00E-6 0.15
13 SGTC_2634 4'-methoxyflavone 4.60 100.0 µM 4.52E-6 4 2.14E-6 0.23
14 SGTC_2707 st078556 4.58 66.6 µM 4.96E-6 2 2.36E-6 0.36
15 SGTC_2699 st077704 4.48 54.6 µM 7.54E-6 endomembrane recycling 5 3.68E-6 1.00
16 SGTC_2867 9039098 4.45 71.4 µM 8.74E-6 iron homeostasis 9 4.30E-6 0.02
17 SGTC_1055 3448-0672 4.07 86.0 µM 4.38E-5 10 2.39E-5 0.10
18 SGTC_1161 k007-0610 4.05 110.0 µM 4.69E-5 ERAD & cell cycle 41 2.56E-5 0.03
19 SGTC_1664 st014217 3.98 9.0 µM 6.24E-5 60S ribosome export 4 3.48E-5 0.09
20 SGTC_1420 4'-methoxyflavone 3.96 42.0 µM 6.79E-5 5 3.80E-5 0.51

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.313 5.57E-77 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.192 3.94E-29 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.172 1.06E-23 YOL127W RPL25 het Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
0.169 6.41E-23 YAL038W CDC19 het Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
0.156 8.26E-20 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.147 1.11E-17 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.143 7.00E-17 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.142 1.14E-16 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.132 1.63E-14 YDR526C_d YDR526C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.129 6.77E-14 YPR153W YPR153W hom Putative protein of unknown function
0.122 1.23E-12 YHR005C-A TIM10 het Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
0.119 4.79E-12 YNR017W TIM23 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
0.118 6.02E-12 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.116 1.37E-11 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.115 2.59E-11 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex