YDL168W / SFA1

Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL168W / SFA1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:5.40|P-value:7.70E-7 ID:SGTC_44|Compound:0929-0055|FD-Score:4.89|P-value:6.70E-6 ID:SGTC_84|Compound:0443-0269|FD-Score:-4.13|P-value:8.87E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.91|P-value:1.92E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.65|P-value:6.01E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.63|P-value:6.45E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.49|P-value:9.82E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.49|P-value:9.97E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.82|P-value:2.57E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.29|P-value:6.96E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.26|P-value:7.77E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.62|P-value:2.02E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.68|P-value:5.52E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:-4.61|P-value:1.45E-5 ID:SGTC_1763|Compound:st044482|FD-Score:6.38|P-value:6.58E-9 ID:SGTC_1822|Compound:st052468|FD-Score:4.37|P-value:5.09E-5 ID:SGTC_1825|Compound:st052143|FD-Score:-3.72|P-value:3.55E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.73|P-value:4.72E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.64|P-value:4.68E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.79|P-value:3.88E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.60|P-value:7.17E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.50|P-value:9.56E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.67|P-value:5.61E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.68|P-value:5.55E-4 ID:SGTC_2314|Compound:7727897|FD-Score:5.11|P-value:2.74E-6 ID:SGTC_2353|Compound:9059630|FD-Score:4.62|P-value:2.00E-5 ID:SGTC_2364|Compound:9055074|FD-Score:4.85|P-value:7.94E-6 ID:SGTC_2388|Compound:9080168|FD-Score:4.16|P-value:1.09E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-3.76|P-value:3.19E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.44|P-value:2.82E-5 ID:SGTC_2843|Compound:9000894|FD-Score:-3.61|P-value:5.18E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.42|P-value:4.33E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-4.72|P-value:9.36E-6 ID:SGTC_2961|Compound:9083290|FD-Score:3.66|P-value:5.93E-4 ID:SGTC_3005|Compound:9076496|FD-Score:5.21|P-value:1.73E-6 ID:SGTC_3202|Compound:9113761|FD-Score:-5.69|P-value:1.28E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:5.40|P-value:7.70E-7 ID:SGTC_44|Compound:0929-0055|FD-Score:4.89|P-value:6.70E-6 ID:SGTC_84|Compound:0443-0269|FD-Score:-4.13|P-value:8.87E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.91|P-value:1.92E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.65|P-value:6.01E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.63|P-value:6.45E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.49|P-value:9.82E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.49|P-value:9.97E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.82|P-value:2.57E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.29|P-value:6.96E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.26|P-value:7.77E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.62|P-value:2.02E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.68|P-value:5.52E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:-4.61|P-value:1.45E-5 ID:SGTC_1763|Compound:st044482|FD-Score:6.38|P-value:6.58E-9 ID:SGTC_1822|Compound:st052468|FD-Score:4.37|P-value:5.09E-5 ID:SGTC_1825|Compound:st052143|FD-Score:-3.72|P-value:3.55E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.73|P-value:4.72E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.64|P-value:4.68E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.79|P-value:3.88E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.60|P-value:7.17E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.50|P-value:9.56E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.67|P-value:5.61E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.68|P-value:5.55E-4 ID:SGTC_2314|Compound:7727897|FD-Score:5.11|P-value:2.74E-6 ID:SGTC_2353|Compound:9059630|FD-Score:4.62|P-value:2.00E-5 ID:SGTC_2364|Compound:9055074|FD-Score:4.85|P-value:7.94E-6 ID:SGTC_2388|Compound:9080168|FD-Score:4.16|P-value:1.09E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-3.76|P-value:3.19E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.44|P-value:2.82E-5 ID:SGTC_2843|Compound:9000894|FD-Score:-3.61|P-value:5.18E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.42|P-value:4.33E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-4.72|P-value:9.36E-6 ID:SGTC_2961|Compound:9083290|FD-Score:3.66|P-value:5.93E-4 ID:SGTC_3005|Compound:9076496|FD-Score:5.21|P-value:1.73E-6 ID:SGTC_3202|Compound:9113761|FD-Score:-5.69|P-value:1.28E-7

Top fitness defect scores for YDL168W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1763 st044482 6.38 94.5 µM 6.58E-9 copper-dependent oxidative stress 4 9.08E-11
2 SGTC_43 0570-0105 5.40 72.5 µM 7.70E-7 ERG2 47 3.36E-8
3 SGTC_3005 9076496 5.21 71.4 µM 1.73E-6 2 9.20E-8
4 SGTC_2314 7727897 5.11 200.0 µM 2.74E-6 2 1.62E-7
5 SGTC_44 0929-0055 4.89 61.2 µM 6.70E-6 19 4.92E-7
6 SGTC_2364 9055074 4.85 200.0 µM 7.94E-6 8 6.08E-7
7 SGTC_2353 9059630 4.62 146.7 µM 2.00E-5 13 1.91E-6
8 SGTC_1376 2910-0861 4.62 41.3 µM 2.02E-5 9 1.94E-6
9 SGTC_2857 9024691 4.42 58.4 µM 4.33E-5 13 4.98E-6
10 SGTC_1822 st052468 4.37 42.0 µM 5.09E-5 7 6.08E-6
11 SGTC_1159 4092-0538 4.29 61.2 µM 6.96E-5 20 8.97E-6
12 SGTC_1163 k060-0048 4.26 49.9 µM 7.77E-5 15 1.03E-5
13 SGTC_2388 9080168 4.16 200.0 µM 1.09E-4 1 1.57E-5
14 SGTC_2031 5180455 3.79 200.0 µM 3.88E-4 14 7.55E-5
15 SGTC_1914 st062367 3.73 72.6 µM 4.72E-4 26 9.62E-5
16 SGTC_1469 k284-2957 3.68 126.0 µM 5.52E-4 11 1.17E-4
17 SGTC_2270 7924575 3.68 90.9 µM 5.55E-4 RPP1 & pyrimidine depletion 18 1.17E-4
18 SGTC_2117 5521686 3.67 200.0 µM 5.61E-4 20 1.19E-4
19 SGTC_2961 9083290 3.66 32.5 µM 5.93E-4 26 1.27E-4
20 SGTC_94 0334-0113 3.65 514.8 µM 6.01E-4 28 1.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 3.61E-15 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.127 1.86E-13 YKL184W SPE1 hom Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
0.121 2.08E-12 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.109 2.54E-10 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.108 3.17E-10 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.104 1.54E-9 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.101 3.88E-9 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.099 9.60E-9 YOR118W RTC5 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity
0.096 2.38E-8 YLR354C TAL1 hom Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
0.096 2.85E-8 YDL095W PMT1 hom Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
0.096 2.93E-8 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.07E-8 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.093 5.82E-8 YDR409W SIZ1 hom SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.091 1.48E-7 YHR126C_p ANS1_p hom Putative GPI protein; transcription dependent upon Azf1p
0.088 3.14E-7 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene