YDL170W / UGA3

Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL170W / UGA3

Click on Significant Values for Screen Details ID:SGTC_158|Compound:k038-0087|FD-Score:-3.14|P-value:7.23E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.26|P-value:4.52E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.31|P-value:3.84E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.23|P-value:5.16E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.35|P-value:3.19E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.15|P-value:6.77E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.74|P-value:6.99E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:3.12|P-value:7.38E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.31|P-value:3.79E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.21|P-value:5.36E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.20|P-value:5.76E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.62|P-value:1.14E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:6.25|P-value:9.81E-11 ID:SGTC_1329|Compound:1447-1697|FD-Score:5.92|P-value:8.09E-10 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.57|P-value:1.39E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.76|P-value:6.49E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.63|P-value:1.08E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.24|P-value:4.96E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.12|P-value:7.36E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.50|P-value:1.83E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.38|P-value:2.88E-4 ID:SGTC_1983|Compound:st071813|FD-Score:5.33|P-value:2.87E-8 ID:SGTC_1987|Compound:st072290|FD-Score:4.82|P-value:4.70E-7 ID:SGTC_1988|Compound:st071872|FD-Score:6.49|P-value:1.97E-11 ID:SGTC_1991|Compound:st073000|FD-Score:3.32|P-value:3.58E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-4.55|P-value:1.92E-6 ID:SGTC_1996|Compound:st072960|FD-Score:4.45|P-value:2.97E-6 ID:SGTC_2035|Compound:5154463|FD-Score:-3.46|P-value:2.20E-4 ID:SGTC_2038|Compound:4100038|FD-Score:4.25|P-value:7.46E-6 ID:SGTC_2047|Compound:4141938|FD-Score:-3.55|P-value:1.52E-4 ID:SGTC_2217|Compound:6934799|FD-Score:4.11|P-value:1.42E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.19|P-value:5.84E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.28|P-value:4.18E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.07|P-value:9.19E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.08|P-value:8.64E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.53|P-value:1.99E-6 ID:SGTC_2426|Compound:5582046|FD-Score:3.44|P-value:2.26E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.13|P-value:7.24E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.56|P-value:1.52E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.09|P-value:1.64E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.05|P-value:1.83E-5 ID:SGTC_2537|Compound:larixol|FD-Score:5.58|P-value:6.72E-9 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.80|P-value:5.46E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.09|P-value:8.35E-4 ID:SGTC_2870|Compound:9038528|FD-Score:5.55|P-value:8.20E-9 ID:SGTC_2871|Compound:9038510|FD-Score:-4.05|P-value:1.91E-5 ID:SGTC_2875|Compound:9039966|FD-Score:3.83|P-value:4.73E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.07|P-value:8.91E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.49|P-value:1.90E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.65|P-value:1.02E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.14|P-value:7.23E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.26|P-value:4.52E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.31|P-value:3.84E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.23|P-value:5.16E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.35|P-value:3.19E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.15|P-value:6.77E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.74|P-value:6.99E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:3.12|P-value:7.38E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.31|P-value:3.79E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.21|P-value:5.36E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.20|P-value:5.76E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.62|P-value:1.14E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:6.25|P-value:9.81E-11 ID:SGTC_1329|Compound:1447-1697|FD-Score:5.92|P-value:8.09E-10 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.57|P-value:1.39E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.76|P-value:6.49E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.63|P-value:1.08E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.24|P-value:4.96E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.12|P-value:7.36E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.50|P-value:1.83E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.38|P-value:2.88E-4 ID:SGTC_1983|Compound:st071813|FD-Score:5.33|P-value:2.87E-8 ID:SGTC_1987|Compound:st072290|FD-Score:4.82|P-value:4.70E-7 ID:SGTC_1988|Compound:st071872|FD-Score:6.49|P-value:1.97E-11 ID:SGTC_1991|Compound:st073000|FD-Score:3.32|P-value:3.58E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-4.55|P-value:1.92E-6 ID:SGTC_1996|Compound:st072960|FD-Score:4.45|P-value:2.97E-6 ID:SGTC_2035|Compound:5154463|FD-Score:-3.46|P-value:2.20E-4 ID:SGTC_2038|Compound:4100038|FD-Score:4.25|P-value:7.46E-6 ID:SGTC_2047|Compound:4141938|FD-Score:-3.55|P-value:1.52E-4 ID:SGTC_2217|Compound:6934799|FD-Score:4.11|P-value:1.42E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.19|P-value:5.84E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.28|P-value:4.18E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.07|P-value:9.19E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.08|P-value:8.64E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.53|P-value:1.99E-6 ID:SGTC_2426|Compound:5582046|FD-Score:3.44|P-value:2.26E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.13|P-value:7.24E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.56|P-value:1.52E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.09|P-value:1.64E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.05|P-value:1.83E-5 ID:SGTC_2537|Compound:larixol|FD-Score:5.58|P-value:6.72E-9 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.80|P-value:5.46E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.09|P-value:8.35E-4 ID:SGTC_2870|Compound:9038528|FD-Score:5.55|P-value:8.20E-9 ID:SGTC_2871|Compound:9038510|FD-Score:-4.05|P-value:1.91E-5 ID:SGTC_2875|Compound:9039966|FD-Score:3.83|P-value:4.73E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.07|P-value:8.91E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.49|P-value:1.90E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.65|P-value:1.02E-4

Top fitness defect scores for YDL170W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1988 st071872 6.49 53.4 µM 1.97E-11 1 4.33E-11
2 SGTC_1055 3448-0672 6.25 86.0 µM 9.81E-11 9 2.04E-10
3 SGTC_1329 1447-1697 5.92 50.6 µM 8.09E-10 3 1.56E-9
4 SGTC_2537 larixol 5.58 68.9 µM 6.72E-9 7 1.21E-8
5 SGTC_2870 9038528 5.55 13.0 µM 8.20E-9 3 1.47E-8
6 SGTC_1983 st071813 5.33 46.9 µM 2.87E-8 RPP1 & pyrimidine depletion 4 4.91E-8
7 SGTC_1987 st072290 4.82 61.9 µM 4.70E-7 4 7.34E-7
8 SGTC_2410 aloe-emodin-8-o-glycoside 4.53 46.3 µM 1.99E-6 mitochondrial processes 13 2.96E-6
9 SGTC_1996 st072960 4.45 66.8 µM 2.97E-6 6 4.36E-6
10 SGTC_2038 4100038 4.25 31.0 µM 7.46E-6 plasma membrane duress 40 1.06E-5
11 SGTC_2217 6934799 4.11 96.1 µM 1.42E-5 TSC3-RPN4 7 1.98E-5
12 SGTC_2536 dehydroabietamide 4.05 32.0 µM 1.83E-5 31 2.53E-5
13 SGTC_2875 9039966 3.83 71.4 µM 4.73E-5 11 6.33E-5
14 SGTC_2538 3',7'-epoxycaryophyllan-6-one 3.80 100.0 µM 5.46E-5 27 7.27E-5
15 SGTC_1333 1482-0047 3.76 286.0 µM 6.49E-5 21 8.60E-5
16 SGTC_603 3794-0023 3.74 45.9 µM 6.99E-5 16 9.24E-5
17 SGTC_3294 9122953 3.65 26.3 µM 1.02E-4 tubulin folding & SWR complex 36 1.33E-4
18 SGTC_1346 1488-2224 3.63 62.4 µM 1.08E-4 23 1.41E-4
19 SGTC_1050 3232-1156 3.62 69.3 µM 1.14E-4 RSC complex & mRNA processing 30 1.49E-4
20 SGTC_1330 1469-0054 3.57 61.8 µM 1.39E-4 iron homeostasis 28 1.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.51E-9 YML113W DAT1 hom DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
0.081 2.83E-6 YMR209C_p YMR209C_p hom Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene
0.079 4.32E-6 YDL054C MCH1 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.075 1.36E-5 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
0.074 1.59E-5 YDR265W PEX10 hom Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders
0.074 1.68E-5 YLR108C YLR108C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication
0.070 5.55E-5 YLR064W PER33 hom Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress
0.069 5.80E-5 YLR130C ZRT2 hom Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor
0.068 7.67E-5 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.068 8.07E-5 YJR044C VPS55 hom Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)
0.068 8.97E-5 YDL180W_p YDL180W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.066 1.23E-4 YDR079C-A TFB5 hom Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair
0.066 1.38E-4 YDL239C ADY3 hom Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication
0.065 1.63E-4 YNL094W APP1 hom Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway
0.063 2.44E-4 YNL313C EMW1 het Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress