YDL172C_d

Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL172C / YDL172C

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-5.16|P-value:6.34E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:7.98|P-value:5.62E-14 ID:SGTC_59|Compound:0330-0160|FD-Score:5.13|P-value:9.47E-7 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.50|P-value:4.96E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-8.11|P-value:1.46E-14 ID:SGTC_87|Compound:0100-0052|FD-Score:4.42|P-value:2.04E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.49|P-value:6.23E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.82|P-value:1.98E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.58|P-value:3.76E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.36|P-value:1.68E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.60|P-value:3.55E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.26|P-value:2.92E-9 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.42|P-value:6.28E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:4.33|P-value:3.02E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:4.62|P-value:9.13E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:3.50|P-value:5.95E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:5.58|P-value:1.07E-7 ID:SGTC_974|Compound:1326-0144|FD-Score:3.39|P-value:8.43E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.17|P-value:5.58E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.59|P-value:3.57E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.50|P-value:1.65E-7 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.71|P-value:2.95E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.65|P-value:3.63E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.42|P-value:6.36E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.56|P-value:4.83E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.68|P-value:3.30E-4 ID:SGTC_1635|Compound:st007035|FD-Score:13.90|P-value:1.18E-38 ID:SGTC_1697|Compound:st025554|FD-Score:3.68|P-value:3.22E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-5.61|P-value:7.02E-8 ID:SGTC_1717|Compound:st033143|FD-Score:3.55|P-value:5.02E-4 ID:SGTC_1745|Compound:st081495|FD-Score:6.26|P-value:2.99E-9 ID:SGTC_1750|Compound:st081859|FD-Score:6.02|P-value:1.08E-8 ID:SGTC_1754|Compound:st042065|FD-Score:-5.48|P-value:1.30E-7 ID:SGTC_1786|Compound:berberine|FD-Score:-5.64|P-value:5.86E-8 ID:SGTC_1800|Compound:st050079|FD-Score:-3.37|P-value:7.44E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.29|P-value:9.65E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.49|P-value:4.98E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.20|P-value:2.72E-30 ID:SGTC_1909|Compound:st060837|FD-Score:4.98|P-value:1.89E-6 ID:SGTC_1970|Compound:st070122|FD-Score:4.01|P-value:1.02E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.41|P-value:8.00E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.80|P-value:2.15E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.10|P-value:5.70E-5 ID:SGTC_2306|Compound:7482397|FD-Score:4.81|P-value:3.97E-6 ID:SGTC_2310|Compound:7668677|FD-Score:3.37|P-value:9.15E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.70|P-value:1.20E-32 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.43|P-value:7.49E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.23|P-value:4.45E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.60|P-value:2.05E-19 ID:SGTC_2807|Compound:7945238|FD-Score:5.63|P-value:8.43E-8 ID:SGTC_2849|Compound:9019321|FD-Score:-5.88|P-value:1.67E-8 ID:SGTC_2850|Compound:9015429|FD-Score:-4.20|P-value:3.85E-5 ID:SGTC_2859|Compound:9028643|FD-Score:5.98|P-value:1.41E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-3.54|P-value:4.34E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.00|P-value:1.05E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.35|P-value:9.61E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.38|P-value:7.19E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.69|P-value:3.13E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.71|P-value:2.95E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.52|P-value:1.40E-5 ID:SGTC_2999|Compound:9069765|FD-Score:5.06|P-value:1.30E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-4.69|P-value:5.13E-6 ID:SGTC_3167|Compound:9103034|FD-Score:3.37|P-value:9.17E-4 ID:SGTC_3219|Compound:9131112|FD-Score:5.27|P-value:5.02E-7 ID:SGTC_3228|Compound:9131799|FD-Score:4.19|P-value:5.03E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.93|P-value:1.34E-4 ID:SGTC_3237|Compound:9133362|FD-Score:4.38|P-value:2.41E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.16|P-value:6.34E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:7.98|P-value:5.62E-14 ID:SGTC_59|Compound:0330-0160|FD-Score:5.13|P-value:9.47E-7 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.50|P-value:4.96E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-8.11|P-value:1.46E-14 ID:SGTC_87|Compound:0100-0052|FD-Score:4.42|P-value:2.04E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.49|P-value:6.23E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.82|P-value:1.98E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.58|P-value:3.76E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.36|P-value:1.68E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.60|P-value:3.55E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.26|P-value:2.92E-9 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.42|P-value:6.28E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:4.33|P-value:3.02E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:4.62|P-value:9.13E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:3.50|P-value:5.95E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:5.58|P-value:1.07E-7 ID:SGTC_974|Compound:1326-0144|FD-Score:3.39|P-value:8.43E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.17|P-value:5.58E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.59|P-value:3.57E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.50|P-value:1.65E-7 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.71|P-value:2.95E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.65|P-value:3.63E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.42|P-value:6.36E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.56|P-value:4.83E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.68|P-value:3.30E-4 ID:SGTC_1635|Compound:st007035|FD-Score:13.90|P-value:1.18E-38 ID:SGTC_1697|Compound:st025554|FD-Score:3.68|P-value:3.22E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-5.61|P-value:7.02E-8 ID:SGTC_1717|Compound:st033143|FD-Score:3.55|P-value:5.02E-4 ID:SGTC_1745|Compound:st081495|FD-Score:6.26|P-value:2.99E-9 ID:SGTC_1750|Compound:st081859|FD-Score:6.02|P-value:1.08E-8 ID:SGTC_1754|Compound:st042065|FD-Score:-5.48|P-value:1.30E-7 ID:SGTC_1786|Compound:berberine|FD-Score:-5.64|P-value:5.86E-8 ID:SGTC_1800|Compound:st050079|FD-Score:-3.37|P-value:7.44E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.29|P-value:9.65E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.49|P-value:4.98E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.20|P-value:2.72E-30 ID:SGTC_1909|Compound:st060837|FD-Score:4.98|P-value:1.89E-6 ID:SGTC_1970|Compound:st070122|FD-Score:4.01|P-value:1.02E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.41|P-value:8.00E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.80|P-value:2.15E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.10|P-value:5.70E-5 ID:SGTC_2306|Compound:7482397|FD-Score:4.81|P-value:3.97E-6 ID:SGTC_2310|Compound:7668677|FD-Score:3.37|P-value:9.15E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.70|P-value:1.20E-32 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.43|P-value:7.49E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.23|P-value:4.45E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.60|P-value:2.05E-19 ID:SGTC_2807|Compound:7945238|FD-Score:5.63|P-value:8.43E-8 ID:SGTC_2849|Compound:9019321|FD-Score:-5.88|P-value:1.67E-8 ID:SGTC_2850|Compound:9015429|FD-Score:-4.20|P-value:3.85E-5 ID:SGTC_2859|Compound:9028643|FD-Score:5.98|P-value:1.41E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-3.54|P-value:4.34E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.00|P-value:1.05E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.35|P-value:9.61E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.38|P-value:7.19E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.69|P-value:3.13E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.71|P-value:2.95E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.52|P-value:1.40E-5 ID:SGTC_2999|Compound:9069765|FD-Score:5.06|P-value:1.30E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-4.69|P-value:5.13E-6 ID:SGTC_3167|Compound:9103034|FD-Score:3.37|P-value:9.17E-4 ID:SGTC_3219|Compound:9131112|FD-Score:5.27|P-value:5.02E-7 ID:SGTC_3228|Compound:9131799|FD-Score:4.19|P-value:5.03E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.93|P-value:1.34E-4 ID:SGTC_3237|Compound:9133362|FD-Score:4.38|P-value:2.41E-5

Top fitness defect scores for YDL172C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 13.90 42.4 µM 1.18E-38 48 3.33E-44
2 SGTC_2582 agaric acid 12.70 100.0 µM 1.20E-32 redox potentiating 32 2.64E-37
3 SGTC_1844 rapamycin 12.20 4.0 nM 2.72E-30 21 1.34E-34
4 SGTC_2679 rapamycin 9.60 1.0 nM 2.05E-19 30 4.12E-22
5 SGTC_50 0929-0078 7.98 56.4 µM 5.62E-14 17 7.24E-16
6 SGTC_236 1509-0011 6.36 5.3 µM 1.68E-9 283 1.00E-10
7 SGTC_453 enantio-paf c16 6.26 10.0 µM 2.92E-9 36 1.89E-10
8 SGTC_1745 st081495 6.26 74.0 µM 2.99E-9 RNA processing & uracil transport 23 1.93E-10
9 SGTC_1750 st081859 6.02 2.4 µM 1.08E-8 endomembrane recycling 108 8.49E-10
10 SGTC_2859 9028643 5.98 45.5 µM 1.41E-8 1 1.15E-9
11 SGTC_2807 7945238 5.63 52.0 µM 8.43E-8 6 8.94E-9
12 SGTC_825 1988-2224 5.58 89.6 µM 1.07E-7 cell wall signaling 19 1.17E-8
13 SGTC_1173 0443-0020 5.50 122.0 µM 1.65E-7 TSC3-RPN4 15 1.94E-8
14 SGTC_3219 9131112 5.27 49.5 µM 5.02E-7 Golgi 20 6.92E-8
15 SGTC_59 0330-0160 5.13 1.3 µM 9.47E-7 56 1.43E-7
16 SGTC_2999 9069765 5.06 71.4 µM 1.30E-6 amide catabolism 7 2.06E-7
17 SGTC_1909 st060837 4.98 51.5 µM 1.89E-6 29 3.17E-7
18 SGTC_2306 7482397 4.81 179.5 µM 3.97E-6 RPP1 & pyrimidine depletion 9 7.42E-7
19 SGTC_813 k007-0158 4.62 173.0 µM 9.13E-6 fatty acid desaturase (OLE1) 26 1.93E-6
20 SGTC_2970 9090938 4.52 41.9 µM 1.40E-5 RNA processing & uracil transport 23 3.15E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.415 1.32E-139 YDL173W PAR32 hom Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene
0.308 1.84E-74 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.277 4.09E-60 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.274 8.42E-59 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.268 3.07E-56 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.263 3.90E-54 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.262 6.09E-54 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.250 4.49E-49 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.248 2.60E-48 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.244 9.40E-47 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.244 9.02E-47 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.238 2.26E-44 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.237 4.70E-44 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.236 7.88E-44 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.229 5.46E-41 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p