YDL173W / PAR32

Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL173W / PAR32

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.41|P-value:4.36E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.42|P-value:6.64E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:5.05|P-value:3.53E-6 ID:SGTC_72|Compound:0744-0168|FD-Score:4.79|P-value:1.03E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.78|P-value:3.74E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.96|P-value:5.10E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:6.61|P-value:2.06E-9 ID:SGTC_147|Compound:4466-0538|FD-Score:5.34|P-value:9.94E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:3.60|P-value:6.74E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:9.23|P-value:1.01E-16 ID:SGTC_163|Compound:1327-0036|FD-Score:6.05|P-value:3.71E-8 ID:SGTC_204|Compound:1543-0184|FD-Score:3.78|P-value:3.88E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.44|P-value:6.37E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.25|P-value:7.28E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:3.82|P-value:3.46E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:7.34|P-value:3.23E-11 ID:SGTC_354|Compound:2783-3500|FD-Score:3.88|P-value:2.79E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.22|P-value:8.86E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-3.58|P-value:7.00E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.90|P-value:6.45E-6 ID:SGTC_433|Compound:pimozide|FD-Score:-4.09|P-value:1.32E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.07|P-value:1.49E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.82|P-value:3.19E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.25|P-value:1.51E-6 ID:SGTC_639|Compound:0833-0042|FD-Score:4.79|P-value:1.02E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:4.27|P-value:7.19E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:4.54|P-value:2.72E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.63|P-value:6.01E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.61|P-value:6.29E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.96|P-value:2.11E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.80|P-value:3.49E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:-3.48|P-value:9.34E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.77|P-value:3.99E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.20|P-value:9.43E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.04|P-value:1.64E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.26|P-value:7.69E-5 ID:SGTC_1635|Compound:st007035|FD-Score:10.40|P-value:1.14E-20 ID:SGTC_1673|Compound:st016611|FD-Score:5.59|P-value:3.26E-7 ID:SGTC_1712|Compound:st032288|FD-Score:-4.37|P-value:4.86E-5 ID:SGTC_1745|Compound:st081495|FD-Score:6.57|P-value:2.44E-9 ID:SGTC_1750|Compound:st081859|FD-Score:8.04|P-value:4.05E-13 ID:SGTC_1786|Compound:berberine|FD-Score:-4.60|P-value:2.03E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.81|P-value:3.31E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.24|P-value:7.70E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.82|P-value:6.27E-10 ID:SGTC_1896|Compound:st058441|FD-Score:3.83|P-value:3.32E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.10|P-value:1.31E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.54|P-value:7.91E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.64|P-value:6.02E-4 ID:SGTC_2192|Compound:5915882|FD-Score:6.03|P-value:4.02E-8 ID:SGTC_2237|Compound:6667747|FD-Score:6.78|P-value:7.75E-10 ID:SGTC_2239|Compound:6685329|FD-Score:3.82|P-value:3.40E-4 ID:SGTC_2248|Compound:tofa|FD-Score:5.16|P-value:2.23E-6 ID:SGTC_2288|Compound:7946289|FD-Score:4.01|P-value:1.79E-4 ID:SGTC_2292|Compound:7671323|FD-Score:4.50|P-value:3.10E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.57|P-value:7.51E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.58|P-value:2.18E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.70|P-value:4.72E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.68|P-value:5.38E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.93|P-value:2.34E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:9.84|P-value:9.25E-19 ID:SGTC_2582|Compound:agaric acid|FD-Score:14.10|P-value:1.97E-36 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.72|P-value:1.79E-7 ID:SGTC_2754|Compound:granisetron|FD-Score:3.57|P-value:7.41E-4 ID:SGTC_2807|Compound:7945238|FD-Score:4.15|P-value:1.13E-4 ID:SGTC_2815|Compound:7968870|FD-Score:5.26|P-value:1.43E-6 ID:SGTC_3004|Compound:9076122|FD-Score:3.55|P-value:7.92E-4 ID:SGTC_3096|Compound:9117468|FD-Score:3.72|P-value:4.63E-4 ID:SGTC_3341|Compound:9147222|FD-Score:4.62|P-value:1.98E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:4.41|P-value:4.36E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.42|P-value:6.64E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:5.05|P-value:3.53E-6 ID:SGTC_72|Compound:0744-0168|FD-Score:4.79|P-value:1.03E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.78|P-value:3.74E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.96|P-value:5.10E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:6.61|P-value:2.06E-9 ID:SGTC_147|Compound:4466-0538|FD-Score:5.34|P-value:9.94E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:3.60|P-value:6.74E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:9.23|P-value:1.01E-16 ID:SGTC_163|Compound:1327-0036|FD-Score:6.05|P-value:3.71E-8 ID:SGTC_204|Compound:1543-0184|FD-Score:3.78|P-value:3.88E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.44|P-value:6.37E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.25|P-value:7.28E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:3.82|P-value:3.46E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:7.34|P-value:3.23E-11 ID:SGTC_354|Compound:2783-3500|FD-Score:3.88|P-value:2.79E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.22|P-value:8.86E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-3.58|P-value:7.00E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.90|P-value:6.45E-6 ID:SGTC_433|Compound:pimozide|FD-Score:-4.09|P-value:1.32E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.07|P-value:1.49E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.82|P-value:3.19E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.25|P-value:1.51E-6 ID:SGTC_639|Compound:0833-0042|FD-Score:4.79|P-value:1.02E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:4.27|P-value:7.19E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:4.54|P-value:2.72E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.63|P-value:6.01E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.61|P-value:6.29E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.96|P-value:2.11E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.80|P-value:3.49E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:-3.48|P-value:9.34E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.77|P-value:3.99E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.20|P-value:9.43E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.04|P-value:1.64E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.26|P-value:7.69E-5 ID:SGTC_1635|Compound:st007035|FD-Score:10.40|P-value:1.14E-20 ID:SGTC_1673|Compound:st016611|FD-Score:5.59|P-value:3.26E-7 ID:SGTC_1712|Compound:st032288|FD-Score:-4.37|P-value:4.86E-5 ID:SGTC_1745|Compound:st081495|FD-Score:6.57|P-value:2.44E-9 ID:SGTC_1750|Compound:st081859|FD-Score:8.04|P-value:4.05E-13 ID:SGTC_1786|Compound:berberine|FD-Score:-4.60|P-value:2.03E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.81|P-value:3.31E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.24|P-value:7.70E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.82|P-value:6.27E-10 ID:SGTC_1896|Compound:st058441|FD-Score:3.83|P-value:3.32E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.10|P-value:1.31E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.54|P-value:7.91E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.64|P-value:6.02E-4 ID:SGTC_2192|Compound:5915882|FD-Score:6.03|P-value:4.02E-8 ID:SGTC_2237|Compound:6667747|FD-Score:6.78|P-value:7.75E-10 ID:SGTC_2239|Compound:6685329|FD-Score:3.82|P-value:3.40E-4 ID:SGTC_2248|Compound:tofa|FD-Score:5.16|P-value:2.23E-6 ID:SGTC_2288|Compound:7946289|FD-Score:4.01|P-value:1.79E-4 ID:SGTC_2292|Compound:7671323|FD-Score:4.50|P-value:3.10E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.57|P-value:7.51E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.58|P-value:2.18E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.70|P-value:4.72E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.68|P-value:5.38E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.93|P-value:2.34E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:9.84|P-value:9.25E-19 ID:SGTC_2582|Compound:agaric acid|FD-Score:14.10|P-value:1.97E-36 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.72|P-value:1.79E-7 ID:SGTC_2754|Compound:granisetron|FD-Score:3.57|P-value:7.41E-4 ID:SGTC_2807|Compound:7945238|FD-Score:4.15|P-value:1.13E-4 ID:SGTC_2815|Compound:7968870|FD-Score:5.26|P-value:1.43E-6 ID:SGTC_3004|Compound:9076122|FD-Score:3.55|P-value:7.92E-4 ID:SGTC_3096|Compound:9117468|FD-Score:3.72|P-value:4.63E-4 ID:SGTC_3341|Compound:9147222|FD-Score:4.62|P-value:1.98E-5

Top fitness defect scores for YDL173W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 14.10 100.0 µM 1.97E-36 redox potentiating 20 2.14E-45
2 SGTC_1635 st007035 10.40 42.4 µM 1.14E-20 70 1.44E-25
3 SGTC_2573 2',4'-dihydroxychalcone 9.84 15.0 µM 9.25E-19 3 3.61E-23
4 SGTC_161 4065-0411 9.23 162.2 µM 1.01E-16 9 1.31E-20
5 SGTC_1750 st081859 8.04 2.4 µM 4.05E-13 endomembrane recycling 67 4.43E-16
6 SGTC_353 1988-1175 7.34 58.3 µM 3.23E-11 unfolded protein response 6 1.08E-13
7 SGTC_1844 rapamycin 6.82 4.0 nM 6.27E-10 74 4.46E-12
8 SGTC_2237 6667747 6.78 47.2 µM 7.75E-10 1 5.82E-12
9 SGTC_129 0088-0017 6.61 176.6 µM 2.06E-9 26 1.98E-11
10 SGTC_1745 st081495 6.57 74.0 µM 2.44E-9 RNA processing & uracil transport 20 2.45E-11
11 SGTC_163 1327-0036 6.05 7.5 µM 3.71E-8 46 7.44E-10
12 SGTC_2192 5915882 6.03 198.5 µM 4.02E-8 RNA processing & uracil transport 11 8.22E-10
13 SGTC_2679 rapamycin 5.72 1.0 nM 1.79E-7 83 5.32E-9
14 SGTC_1673 st016611 5.59 27.3 µM 3.26E-7 17 1.13E-8
15 SGTC_236 1509-0011 5.44 5.3 µM 6.37E-7 303 2.61E-8
16 SGTC_147 4466-0538 5.34 29.2 µM 9.94E-7 ergosterol biosynthesis 6 4.56E-8
17 SGTC_2815 7968870 5.26 71.4 µM 1.43E-6 6 7.19E-8
18 SGTC_453 enantio-paf c16 5.25 10.0 µM 1.51E-6 79 7.71E-8
19 SGTC_2248 tofa 5.16 1.1 µM 2.23E-6 sphingolipid biosynthesis & PDR1 24 1.26E-7
20 SGTC_59 0330-0160 5.05 1.3 µM 3.53E-6 58 2.22E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.415 1.32E-139 YDL172C_d YDL172C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.288 2.34E-65 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.261 3.51E-53 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.258 4.96E-52 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.249 9.39E-49 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.249 1.56E-48 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.248 2.75E-48 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.247 5.01E-48 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.234 4.19E-43 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.234 8.97E-43 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.232 2.92E-42 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.227 1.70E-40 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.227 2.14E-40 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.222 1.43E-38 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.221 1.77E-38 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p