YDL177C_p

Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL177C / YDL177C

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-3.42|P-value:8.77E-5 ID:SGTC_232|Compound:clozapine|FD-Score:-3.23|P-value:1.97E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.63|P-value:3.11E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:4.31|P-value:1.01E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:3.03|P-value:4.17E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.59|P-value:2.12E-7 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.59|P-value:4.04E-5 ID:SGTC_448|Compound:monastrol|FD-Score:3.22|P-value:1.91E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.25|P-value:1.70E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:-5.14|P-value:8.05E-9 ID:SGTC_489|Compound:paxilline|FD-Score:-4.34|P-value:9.42E-7 ID:SGTC_518|Compound:1021-0119|FD-Score:-2.96|P-value:5.87E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.55|P-value:5.00E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.67|P-value:2.56E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.09|P-value:3.28E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.03|P-value:4.07E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:10.00|P-value:1.01E-28 ID:SGTC_998|Compound:3996-0085|FD-Score:3.22|P-value:1.94E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.84|P-value:1.24E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.98|P-value:5.07E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.00|P-value:5.10E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.21|P-value:2.03E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.00|P-value:5.21E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:-4.86|P-value:4.67E-8 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.58|P-value:3.89E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-2.88|P-value:7.92E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.01|P-value:4.48E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.11|P-value:2.96E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.34|P-value:8.54E-7 ID:SGTC_1999|Compound:st074831|FD-Score:-3.08|P-value:3.64E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.19|P-value:2.20E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.03|P-value:4.14E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.58|P-value:4.20E-5 ID:SGTC_2140|Compound:5586273|FD-Score:-2.86|P-value:8.49E-4 ID:SGTC_2217|Compound:6934799|FD-Score:3.20|P-value:2.07E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.97|P-value:5.22E-4 ID:SGTC_2344|Compound:7990960|FD-Score:2.87|P-value:7.62E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.51|P-value:5.46E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.48|P-value:6.21E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.69|P-value:2.34E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.64|P-value:3.00E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.23|P-value:4.65E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.64|P-value:3.21E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.02|P-value:4.28E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.38|P-value:9.66E-5 ID:SGTC_2693|Compound:st077581|FD-Score:4.50|P-value:3.43E-7 ID:SGTC_2736|Compound:butenafine|FD-Score:3.01|P-value:4.41E-4 ID:SGTC_2818|Compound:7996756|FD-Score:2.90|P-value:6.99E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.99|P-value:5.98E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.51|P-value:5.31E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.14|P-value:2.70E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.13|P-value:2.96E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.04|P-value:3.90E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.42|P-value:8.77E-5 ID:SGTC_232|Compound:clozapine|FD-Score:-3.23|P-value:1.97E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.63|P-value:3.11E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:4.31|P-value:1.01E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:3.03|P-value:4.17E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.59|P-value:2.12E-7 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.59|P-value:4.04E-5 ID:SGTC_448|Compound:monastrol|FD-Score:3.22|P-value:1.91E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.25|P-value:1.70E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:-5.14|P-value:8.05E-9 ID:SGTC_489|Compound:paxilline|FD-Score:-4.34|P-value:9.42E-7 ID:SGTC_518|Compound:1021-0119|FD-Score:-2.96|P-value:5.87E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.55|P-value:5.00E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.67|P-value:2.56E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.09|P-value:3.28E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.03|P-value:4.07E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:10.00|P-value:1.01E-28 ID:SGTC_998|Compound:3996-0085|FD-Score:3.22|P-value:1.94E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.84|P-value:1.24E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.98|P-value:5.07E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.00|P-value:5.10E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.21|P-value:2.03E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.00|P-value:5.21E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:-4.86|P-value:4.67E-8 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.58|P-value:3.89E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-2.88|P-value:7.92E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.01|P-value:4.48E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.11|P-value:2.96E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.34|P-value:8.54E-7 ID:SGTC_1999|Compound:st074831|FD-Score:-3.08|P-value:3.64E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.19|P-value:2.20E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.03|P-value:4.14E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.58|P-value:4.20E-5 ID:SGTC_2140|Compound:5586273|FD-Score:-2.86|P-value:8.49E-4 ID:SGTC_2217|Compound:6934799|FD-Score:3.20|P-value:2.07E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.97|P-value:5.22E-4 ID:SGTC_2344|Compound:7990960|FD-Score:2.87|P-value:7.62E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.51|P-value:5.46E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.48|P-value:6.21E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.69|P-value:2.34E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.64|P-value:3.00E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.23|P-value:4.65E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.64|P-value:3.21E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.02|P-value:4.28E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.38|P-value:9.66E-5 ID:SGTC_2693|Compound:st077581|FD-Score:4.50|P-value:3.43E-7 ID:SGTC_2736|Compound:butenafine|FD-Score:3.01|P-value:4.41E-4 ID:SGTC_2818|Compound:7996756|FD-Score:2.90|P-value:6.99E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.99|P-value:5.98E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.51|P-value:5.31E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.14|P-value:2.70E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.13|P-value:2.96E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.04|P-value:3.90E-4

Top fitness defect scores for YDL177C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 10.00 1.8 µM 1.01E-28 13 4.96E-24
2 SGTC_405 ebelactone b 4.59 50.0 µM 2.12E-7 3 2.24E-6
3 SGTC_2693 st077581 4.50 40.7 µM 3.43E-7 19 3.33E-6
4 SGTC_1741 st038134 4.34 10.2 µM 8.54E-7 21 7.11E-6
5 SGTC_299 1273-0059 4.31 1.4 µM 1.01E-6 21 8.19E-6
6 SGTC_1376 2910-0861 4.00 41.3 µM 5.10E-6 16 3.14E-5
7 SGTC_1452 4194-0072 4.00 190.0 µM 5.21E-6 11 3.20E-5
8 SGTC_2514 salinomycin 3.69 42.7 µM 2.34E-5 56 1.12E-4
9 SGTC_669 0108-0021 3.67 26.2 µM 2.56E-5 fatty acid desaturase (OLE1) 95 1.20E-4
10 SGTC_2537 larixol 3.64 68.9 µM 3.00E-5 31 1.37E-4
11 SGTC_295 k015-0027 3.63 31.0 µM 3.11E-5 PDR1 13 1.41E-4
12 SGTC_1512 0259-0544 3.58 12.2 µM 3.89E-5 28 1.70E-4
13 SGTC_2975 9084847 3.51 53.7 µM 5.31E-5 39 2.21E-4
14 SGTC_2359 9039622 3.51 200.0 µM 5.46E-5 endomembrane recycling 33 2.26E-4
15 SGTC_2367 9070478 3.48 135.4 µM 6.21E-5 cell wall 55 2.52E-4
16 SGTC_2646 retinol 3.38 96.8 µM 9.66E-5 28 3.63E-4
17 SGTC_473 2-arachidonoylglycerol 3.25 10.0 µM 1.70E-4 37 5.83E-4
18 SGTC_448 monastrol 3.22 171.0 µM 1.91E-4 20 6.41E-4
19 SGTC_998 3996-0085 3.22 177.0 µM 1.94E-4 50 6.51E-4
20 SGTC_1448 4255-0083 3.21 152.0 µM 2.03E-4 ERG2 42 6.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.428 1.89E-149 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.402 2.13E-130 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.359 1.58E-102 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.326 5.68E-84 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.311 5.26E-76 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.277 3.95E-60 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.265 6.77E-55 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.246 2.76E-47 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.231 1.07E-41 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.229 3.58E-41 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.205 3.67E-33 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.201 4.81E-32 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.201 5.82E-32 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.200 1.23E-31 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.198 4.37E-31 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress