YDL178W / DLD2

D-lactate dehydrogenase, located in the mitochondrial matrix

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL178W / DLD2

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:4.53|P-value:3.65E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.61|P-value:8.27E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.63|P-value:7.79E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.37|P-value:6.58E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:6.95|P-value:5.03E-10 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.81|P-value:3.08E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:4.15|P-value:1.42E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.17|P-value:1.34E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.37|P-value:6.61E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.66|P-value:7.03E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.80|P-value:4.60E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.76|P-value:5.23E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:5.37|P-value:1.24E-6 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.87|P-value:3.65E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.88|P-value:9.55E-6 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.19|P-value:1.27E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.75|P-value:3.74E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-4.28|P-value:6.09E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:8.32|P-value:1.21E-13 ID:SGTC_1745|Compound:st081495|FD-Score:4.40|P-value:6.05E-5 ID:SGTC_1758|Compound:st042942|FD-Score:-3.82|P-value:3.02E-4 ID:SGTC_1764|Compound:st044502|FD-Score:5.30|P-value:1.67E-6 ID:SGTC_1797|Compound:st048695|FD-Score:-4.96|P-value:4.43E-6 ID:SGTC_1962|Compound:st076595|FD-Score:5.36|P-value:1.29E-6 ID:SGTC_1980|Compound:st071811|FD-Score:-3.60|P-value:6.04E-4 ID:SGTC_2056|Compound:5235370|FD-Score:4.86|P-value:1.05E-5 ID:SGTC_2149|Compound:5554786|FD-Score:4.09|P-value:1.74E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.45|P-value:9.55E-4 ID:SGTC_2240|Compound:6690706|FD-Score:4.42|P-value:5.44E-5 ID:SGTC_2241|Compound:6772625|FD-Score:4.88|P-value:9.70E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.74|P-value:5.47E-4 ID:SGTC_2323|Compound:6148992|FD-Score:4.25|P-value:1.00E-4 ID:SGTC_2326|Compound:6164455|FD-Score:4.05|P-value:2.02E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.76|P-value:5.18E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:6.77|P-value:1.37E-9 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.78|P-value:3.36E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.50|P-value:4.17E-5 ID:SGTC_2987|Compound:9018338|FD-Score:4.06|P-value:1.95E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-3.60|P-value:5.99E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.71|P-value:5.98E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.91|P-value:3.24E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.60|P-value:8.53E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.70|P-value:6.16E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.53|P-value:3.65E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.61|P-value:8.27E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.63|P-value:7.79E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.37|P-value:6.58E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:6.95|P-value:5.03E-10 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.81|P-value:3.08E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:4.15|P-value:1.42E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.17|P-value:1.34E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.37|P-value:6.61E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.66|P-value:7.03E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.80|P-value:4.60E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.76|P-value:5.23E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:5.37|P-value:1.24E-6 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.87|P-value:3.65E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.88|P-value:9.55E-6 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.19|P-value:1.27E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.75|P-value:3.74E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-4.28|P-value:6.09E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:8.32|P-value:1.21E-13 ID:SGTC_1745|Compound:st081495|FD-Score:4.40|P-value:6.05E-5 ID:SGTC_1758|Compound:st042942|FD-Score:-3.82|P-value:3.02E-4 ID:SGTC_1764|Compound:st044502|FD-Score:5.30|P-value:1.67E-6 ID:SGTC_1797|Compound:st048695|FD-Score:-4.96|P-value:4.43E-6 ID:SGTC_1962|Compound:st076595|FD-Score:5.36|P-value:1.29E-6 ID:SGTC_1980|Compound:st071811|FD-Score:-3.60|P-value:6.04E-4 ID:SGTC_2056|Compound:5235370|FD-Score:4.86|P-value:1.05E-5 ID:SGTC_2149|Compound:5554786|FD-Score:4.09|P-value:1.74E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.45|P-value:9.55E-4 ID:SGTC_2240|Compound:6690706|FD-Score:4.42|P-value:5.44E-5 ID:SGTC_2241|Compound:6772625|FD-Score:4.88|P-value:9.70E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.74|P-value:5.47E-4 ID:SGTC_2323|Compound:6148992|FD-Score:4.25|P-value:1.00E-4 ID:SGTC_2326|Compound:6164455|FD-Score:4.05|P-value:2.02E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.76|P-value:5.18E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:6.77|P-value:1.37E-9 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.78|P-value:3.36E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.50|P-value:4.17E-5 ID:SGTC_2987|Compound:9018338|FD-Score:4.06|P-value:1.95E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-3.60|P-value:5.99E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.71|P-value:5.98E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.91|P-value:3.24E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.60|P-value:8.53E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.70|P-value:6.16E-4

Top fitness defect scores for YDL178W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1718 roemerine 8.32 11.9 µM 1.21E-13 redox potentiating 5 4.27E-17
2 SGTC_823 0417-1665 6.95 178.0 µM 5.03E-10 12 1.80E-12
3 SGTC_2592 piperlongumine 6.77 83.3 µM 1.37E-9 TSC3-RPN4 6 6.44E-12
4 SGTC_1462 k081-0014 5.37 26.5 µM 1.24E-6 2 3.86E-8
5 SGTC_1962 st076595 5.36 64.5 µM 1.29E-6 redox potentiating 11 4.09E-8
6 SGTC_1764 st044502 5.30 93.5 µM 1.67E-6 13 5.68E-8
7 SGTC_1489 4065-0444 4.88 182.0 µM 9.55E-6 9 5.24E-7
8 SGTC_2241 6772625 4.88 37.8 µM 9.70E-6 14 5.35E-7
9 SGTC_2056 5235370 4.86 200.0 µM 1.05E-5 25 5.93E-7
10 SGTC_43 0570-0105 4.53 72.5 µM 3.65E-5 ERG2 67 2.90E-6
11 SGTC_2932 9016711 4.50 44.5 µM 4.17E-5 31 3.44E-6
12 SGTC_2240 6690706 4.42 185.9 µM 5.44E-5 11 4.82E-6
13 SGTC_1745 st081495 4.40 74.0 µM 6.05E-5 RNA processing & uracil transport 64 5.53E-6
14 SGTC_245 methotrexate 4.37 289.6 µM 6.58E-5 34 6.15E-6
15 SGTC_1280 0880-0253 4.37 10.1 µM 6.61E-5 10 6.19E-6
16 SGTC_2323 6148992 4.25 148.3 µM 1.00E-4 27 1.05E-5
17 SGTC_1494 4358-1428 4.19 177.0 µM 1.27E-4 15 1.42E-5
18 SGTC_977 1348-1378 4.17 135.0 µM 1.34E-4 20 1.53E-5
19 SGTC_941 3237-0776 4.15 460.0 µM 1.42E-4 12 1.64E-5
20 SGTC_2149 5554786 4.09 194.8 µM 1.74E-4 cell wall signaling 33 2.12E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.02E-14 YER073W ALD5 hom Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
0.109 2.09E-10 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.093 6.04E-8 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.091 1.47E-7 YGR144W THI4 hom Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents
0.089 2.79E-7 YGL063W PUS2 hom Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification
0.087 5.04E-7 YDR520C_p URC2_p hom Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism
0.081 2.38E-6 YER059W PCL6 hom Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding
0.081 2.92E-6 YMR114C YMR114C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
0.080 3.13E-6 YHR159W_p TDA11_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele
0.077 8.09E-6 YML078W CPR3 hom Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria
0.077 8.50E-6 YLR099C ICT1 hom Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.074 1.80E-5 YGL177W_d YGL177W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.074 1.99E-5 YDR217C RAD9 hom DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate
0.070 4.53E-5 YHR096C HXT5 hom Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication
0.070 4.67E-5 YDR261C EXG2 hom Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor