YDL183C

Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL183C / YDL183C

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.54|P-value:5.09E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:6.50|P-value:6.79E-10 ID:SGTC_43|Compound:0570-0105|FD-Score:3.77|P-value:2.34E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:17.20|P-value:8.11E-59 ID:SGTC_67|Compound:0335-0847|FD-Score:9.97|P-value:5.59E-21 ID:SGTC_86|Compound:0417-1630|FD-Score:10.70|P-value:1.07E-23 ID:SGTC_103|Compound:0844-0104|FD-Score:5.34|P-value:3.28E-7 ID:SGTC_106|Compound:0092-0003|FD-Score:4.26|P-value:3.71E-5 ID:SGTC_107|Compound:0358-0022|FD-Score:17.90|P-value:1.10E-63 ID:SGTC_114|Compound:0364-0001|FD-Score:4.29|P-value:3.31E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.80|P-value:1.55E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:17.50|P-value:9.00E-61 ID:SGTC_138|Compound:0850-0259|FD-Score:5.25|P-value:5.01E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:17.30|P-value:2.99E-59 ID:SGTC_158|Compound:k038-0087|FD-Score:8.67|P-value:2.68E-16 ID:SGTC_163|Compound:1327-0036|FD-Score:6.13|P-value:5.54E-9 ID:SGTC_165|Compound:k038-0023|FD-Score:3.43|P-value:7.30E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:4.02|P-value:9.30E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.35|P-value:9.49E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.44|P-value:7.16E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:4.90|P-value:2.51E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:4.81|P-value:3.75E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.62|P-value:3.98E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:-3.53|P-value:4.02E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:-3.28|P-value:9.11E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:7.30|P-value:4.89E-12 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.47|P-value:1.63E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:12.90|P-value:1.26E-33 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.37|P-value:9.05E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.36|P-value:9.32E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.39|P-value:8.34E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.91|P-value:2.47E-6 ID:SGTC_2009|Compound:4012297|FD-Score:4.37|P-value:2.42E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.54|P-value:1.22E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.48|P-value:1.10E-5 ID:SGTC_2393|Compound:9031399|FD-Score:-3.30|P-value:8.39E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.45|P-value:6.84E-4 ID:SGTC_2446|Compound:5162541|FD-Score:4.59|P-value:9.94E-6 ID:SGTC_2451|Compound:5856223|FD-Score:3.34|P-value:9.97E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.71|P-value:2.91E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.11|P-value:6.68E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.34|P-value:9.74E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.96|P-value:1.31E-6 ID:SGTC_2701|Compound:st077767|FD-Score:4.31|P-value:3.06E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.42|P-value:7.73E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-4.45|P-value:1.25E-5 ID:SGTC_2851|Compound:9015922|FD-Score:-4.17|P-value:3.86E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:6.91|P-value:5.82E-11 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.93|P-value:2.27E-6 ID:SGTC_9|Compound:0092-0002|FD-Score:3.54|P-value:5.09E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:6.50|P-value:6.79E-10 ID:SGTC_43|Compound:0570-0105|FD-Score:3.77|P-value:2.34E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:17.20|P-value:8.11E-59 ID:SGTC_67|Compound:0335-0847|FD-Score:9.97|P-value:5.59E-21 ID:SGTC_86|Compound:0417-1630|FD-Score:10.70|P-value:1.07E-23 ID:SGTC_103|Compound:0844-0104|FD-Score:5.34|P-value:3.28E-7 ID:SGTC_106|Compound:0092-0003|FD-Score:4.26|P-value:3.71E-5 ID:SGTC_107|Compound:0358-0022|FD-Score:17.90|P-value:1.10E-63 ID:SGTC_114|Compound:0364-0001|FD-Score:4.29|P-value:3.31E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.80|P-value:1.55E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:17.50|P-value:9.00E-61 ID:SGTC_138|Compound:0850-0259|FD-Score:5.25|P-value:5.01E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:17.30|P-value:2.99E-59 ID:SGTC_158|Compound:k038-0087|FD-Score:8.67|P-value:2.68E-16 ID:SGTC_163|Compound:1327-0036|FD-Score:6.13|P-value:5.54E-9 ID:SGTC_165|Compound:k038-0023|FD-Score:3.43|P-value:7.30E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:4.02|P-value:9.30E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.35|P-value:9.49E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.44|P-value:7.16E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:4.90|P-value:2.51E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:4.81|P-value:3.75E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.62|P-value:3.98E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:-3.53|P-value:4.02E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:-3.28|P-value:9.11E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:7.30|P-value:4.89E-12 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.47|P-value:1.63E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:12.90|P-value:1.26E-33 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.37|P-value:9.05E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.36|P-value:9.32E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.39|P-value:8.34E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.91|P-value:2.47E-6 ID:SGTC_2009|Compound:4012297|FD-Score:4.37|P-value:2.42E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.54|P-value:1.22E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.48|P-value:1.10E-5 ID:SGTC_2393|Compound:9031399|FD-Score:-3.30|P-value:8.39E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.45|P-value:6.84E-4 ID:SGTC_2446|Compound:5162541|FD-Score:4.59|P-value:9.94E-6 ID:SGTC_2451|Compound:5856223|FD-Score:3.34|P-value:9.97E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.71|P-value:2.91E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.11|P-value:6.68E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.34|P-value:9.74E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.96|P-value:1.31E-6 ID:SGTC_2701|Compound:st077767|FD-Score:4.31|P-value:3.06E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.42|P-value:7.73E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-4.45|P-value:1.25E-5 ID:SGTC_2851|Compound:9015922|FD-Score:-4.17|P-value:3.86E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:6.91|P-value:5.82E-11 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.93|P-value:2.27E-6

Top fitness defect scores for YDL183C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_107 0358-0022 17.90 2.7 µM 1.10E-63 SWF1 & branched chain AA biosynthesis 3 2.74E-72
2 SGTC_137 0438-0332 17.50 85.4 µM 9.00E-61 ubiquinone biosynthesis & proteasome 8 5.61E-69
3 SGTC_142 0335-0849 17.30 62.7 µM 2.99E-59 ubiquinone biosynthesis & proteasome 13 3.00E-67
4 SGTC_64 000l-0018 17.20 272.1 µM 8.11E-59 ubiquinone biosynthesis & proteasome 16 9.34E-67
5 SGTC_1294 1000-1494 12.90 117.0 µM 1.26E-33 8 4.09E-38
6 SGTC_86 0417-1630 10.70 471.9 µM 1.07E-23 ubiquinone biosynthesis & proteasome 34 8.01E-27
7 SGTC_67 0335-0847 9.97 266.0 µM 5.59E-21 ubiquinone biosynthesis & proteasome 23 9.88E-24
8 SGTC_158 k038-0087 8.67 26.4 µM 2.68E-16 ubiquinone biosynthesis & proteasome 41 2.09E-18
9 SGTC_794 k038-0031 7.30 316.0 µM 4.89E-12 ubiquinone biosynthesis & proteasome 39 1.48E-13
10 SGTC_3059 1327-0034 6.91 3.0 µM 5.82E-11 25 2.48E-12
11 SGTC_36 0335-0881 6.50 14.2 µM 6.79E-10 ubiquinone biosynthesis & proteasome 53 4.06E-11
12 SGTC_163 1327-0036 6.13 7.5 µM 5.54E-9 44 4.43E-10
13 SGTC_103 0844-0104 5.34 51.8 µM 3.28E-7 ERAD & cell cycle 94 4.62E-8
14 SGTC_138 0850-0259 5.25 40.9 µM 5.01E-7 cell wall 136 7.49E-8
15 SGTC_3063 1327-0034 4.93 4.0 µM 2.27E-6 29 4.17E-7
16 SGTC_1718 roemerine 4.91 11.9 µM 2.47E-6 redox potentiating 23 4.61E-7
17 SGTC_294 k038-0071 4.90 157.0 µM 2.51E-6 ubiquinone biosynthesis & proteasome 35 4.68E-7
18 SGTC_340 k038-0059 4.81 454.0 µM 3.75E-6 ubiquinone biosynthesis & proteasome 33 7.40E-7
19 SGTC_2446 5162541 4.59 200.0 µM 9.94E-6 5 2.24E-6
20 SGTC_2111 5486399 4.54 200.0 µM 1.22E-5 30 2.83E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.685 0 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.673 0 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.663 0 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.662 0 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.648 0 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.616 0 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.600 0 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.577 3.88E-297 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.548 1.14E-261 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.538 1.50E-250 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.506 8.60E-218 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.499 2.50E-210 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.493 9.54E-205 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.487 4.00E-199 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.486 3.78E-198 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex