YDL184C / RPL41A

Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL184C / RPL41A

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-4.34|P-value:8.46E-7 ID:SGTC_143|Compound:4032-1194|FD-Score:3.00|P-value:5.52E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.37|P-value:7.20E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.22|P-value:1.86E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-4.08|P-value:3.31E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:3.04|P-value:4.81E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide (4-NQO)|FD-Score:-2.79|P-value:9.88E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.23|P-value:1.73E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:2.96|P-value:6.53E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:2.85|P-value:9.66E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.20|P-value:2.00E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:4.70|P-value:1.45E-7 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.08|P-value:3.30E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.15|P-value:3.06E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:2.85|P-value:9.76E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.68|P-value:1.24E-7 ID:SGTC_964|Compound:1287-0107|FD-Score:6.01|P-value:2.64E-11 ID:SGTC_966|Compound:1300-0360|FD-Score:-4.77|P-value:7.11E-8 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.14|P-value:3.26E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.12|P-value:3.48E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-2.79|P-value:9.90E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-2.92|P-value:6.09E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:2.86|P-value:9.50E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.37|P-value:9.64E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.00|P-value:5.64E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-3.16|P-value:2.32E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.77|P-value:1.54E-5 ID:SGTC_2354|Compound:9060492|FD-Score:3.14|P-value:3.20E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-3.11|P-value:2.86E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.28|P-value:1.82E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.04|P-value:4.76E-4 ID:SGTC_2993|Compound:9054257|FD-Score:2.89|P-value:8.54E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.63|P-value:3.84E-5 ID:SGTC_3233|Compound:9132340|FD-Score:-3.00|P-value:4.48E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.34|P-value:8.46E-7 ID:SGTC_143|Compound:4032-1194|FD-Score:3.00|P-value:5.52E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.37|P-value:7.20E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.22|P-value:1.86E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-4.08|P-value:3.31E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:3.04|P-value:4.81E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide (4-NQO)|FD-Score:-2.79|P-value:9.88E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.23|P-value:1.73E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:2.96|P-value:6.53E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:2.85|P-value:9.66E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.20|P-value:2.00E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:4.70|P-value:1.45E-7 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.08|P-value:3.30E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.15|P-value:3.06E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:2.85|P-value:9.76E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.68|P-value:1.24E-7 ID:SGTC_964|Compound:1287-0107|FD-Score:6.01|P-value:2.64E-11 ID:SGTC_966|Compound:1300-0360|FD-Score:-4.77|P-value:7.11E-8 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.14|P-value:3.26E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.12|P-value:3.48E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-2.79|P-value:9.90E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-2.92|P-value:6.09E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:2.86|P-value:9.50E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.37|P-value:9.64E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.00|P-value:5.64E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-3.16|P-value:2.32E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.77|P-value:1.54E-5 ID:SGTC_2354|Compound:9060492|FD-Score:3.14|P-value:3.20E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-3.11|P-value:2.86E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.28|P-value:1.82E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.04|P-value:4.76E-4 ID:SGTC_2993|Compound:9054257|FD-Score:2.89|P-value:8.54E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.63|P-value:3.84E-5 ID:SGTC_3233|Compound:9132340|FD-Score:-3.00|P-value:4.48E-4

Top fitness defect scores for YDL184C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_964 1287-0107 6.01 19.4 µM 2.64E-11 cell wall 12 9.25E-10
2 SGTC_875 0709-0210 4.70 25.7 µM 1.45E-7 fatty acid desaturase (OLE1) 21 1.27E-6
3 SGTC_3027 9089541 3.63 49.5 µM 3.84E-5 fatty acid desaturase (OLE1) 29 1.40E-4
4 SGTC_2757 clomiphene 3.28 4.2 µM 1.82E-4 fatty acid desaturase (OLE1) 74 5.23E-4
5 SGTC_934 2950-0684 3.15 338.0 µM 3.06E-4 46 8.13E-4
6 SGTC_2354 9060492 3.14 162.0 µM 3.20E-4 53 8.45E-4
7 SGTC_1088 bifonazole 3.14 369.0 nM 3.26E-4 41 8.59E-4
8 SGTC_1089 terbinafine 3.12 2.2 µM 3.48E-4 42 9.08E-4
9 SGTC_2933 9026794 3.04 32.5 µM 4.76E-4 73 0.00118
10 SGTC_266 formosanin C 3.04 406.0 nM 4.81E-4 sphingolipid biosynthesis & PDR1 110 0.00119
11 SGTC_143 4032-1194 3.00 15.7 µM 5.52E-4 137 0.00134
12 SGTC_1683 st010134 3.00 710.0 nM 5.64E-4 77 0.00137
13 SGTC_427 1354-0053 2.96 47.3 µM 6.53E-4 67 0.00155
14 SGTC_2993 9054257 2.89 71.4 µM 8.54E-4 fatty acid desaturase (OLE1) 118 0.00194
15 SGTC_1390 3413-2614 2.86 145.0 µM 9.50E-4 fatty acid desaturase (OLE1) 79 0.00213
16 SGTC_534 k292-0788 2.85 63.4 µM 9.66E-4 mitochondrial processes 75 0.00216
17 SGTC_943 3253-1379 2.85 105.0 µM 9.76E-4 79 0.00218
18 SGTC_3038 9091290 2.80 49.5 µM 0.00120 69 0.00259
19 SGTC_976 1348-1067 2.77 47.6 µM 0.00134 60S ribosome export 103 0.00285
20 SGTC_1589 2',5'-dimethoxyflavone 2.74 47.2 µM 0.00144 86 0.00304

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.13E-22 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.155 1.84E-19 YDR162C NBP2 hom Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)
0.122 1.12E-12 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.117 1.14E-11 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.113 4.41E-11 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.109 2.06E-10 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.105 1.15E-9 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.103 1.98E-9 YPR182W SMX3 het Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
0.103 1.99E-9 YBL050W SEC17 het Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP
0.103 2.57E-9 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.098 1.31E-8 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.098 1.47E-8 YNR019W ARE2 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication
0.097 1.57E-8 YBL019W APN2 hom Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
0.097 2.02E-8 YDR100W TVP15 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
0.096 2.43E-8 YDR274C_d YDR274C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data