YDL186W_p

Putative protein of unknown function; YDL186W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL186W / YDL186W

Click on Significant Values for Screen Details ID:SGTC_299|Compound:1273-0059|FD-Score:4.20|P-value:7.13E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:3.21|P-value:4.64E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.74|P-value:5.63E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:9.59|P-value:1.84E-23 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.60|P-value:9.95E-7 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.01|P-value:9.38E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.27|P-value:3.70E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.11|P-value:1.11E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.93|P-value:2.51E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.25|P-value:5.57E-6 ID:SGTC_1341|Compound:1486-1360|FD-Score:-3.74|P-value:5.46E-5 ID:SGTC_1603|Compound:st002045|FD-Score:6.85|P-value:7.18E-13 ID:SGTC_1605|Compound:st000082|FD-Score:3.17|P-value:5.34E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.92|P-value:2.55E-5 ID:SGTC_2331|Compound:7980721|FD-Score:-3.25|P-value:3.85E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.70|P-value:6.03E-7 ID:SGTC_2429|Compound:5902844|FD-Score:3.56|P-value:1.18E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.35|P-value:2.65E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.34|P-value:2.77E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.22|P-value:6.49E-6 ID:SGTC_2957|Compound:9076800|FD-Score:4.51|P-value:1.56E-6 ID:SGTC_3050|Compound:9093513|FD-Score:-3.74|P-value:5.54E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-3.04|P-value:8.29E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-3.06|P-value:7.72E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.18|P-value:4.96E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.04|P-value:8.25E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.18|P-value:5.03E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.20|P-value:7.13E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:3.21|P-value:4.64E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.74|P-value:5.63E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:9.59|P-value:1.84E-23 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.60|P-value:9.95E-7 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.01|P-value:9.38E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.27|P-value:3.70E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.11|P-value:1.11E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.93|P-value:2.51E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.25|P-value:5.57E-6 ID:SGTC_1341|Compound:1486-1360|FD-Score:-3.74|P-value:5.46E-5 ID:SGTC_1603|Compound:st002045|FD-Score:6.85|P-value:7.18E-13 ID:SGTC_1605|Compound:st000082|FD-Score:3.17|P-value:5.34E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.92|P-value:2.55E-5 ID:SGTC_2331|Compound:7980721|FD-Score:-3.25|P-value:3.85E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.70|P-value:6.03E-7 ID:SGTC_2429|Compound:5902844|FD-Score:3.56|P-value:1.18E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.35|P-value:2.65E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.34|P-value:2.77E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.22|P-value:6.49E-6 ID:SGTC_2957|Compound:9076800|FD-Score:4.51|P-value:1.56E-6 ID:SGTC_3050|Compound:9093513|FD-Score:-3.74|P-value:5.54E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-3.04|P-value:8.29E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-3.06|P-value:7.72E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.18|P-value:4.96E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.04|P-value:8.25E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.18|P-value:5.03E-4

Top fitness defect scores for YDL186W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 9.59 1.8 µM 1.84E-23 15 4.26E-22
2 SGTC_1603 st002045 6.85 67.8 µM 7.18E-13 TSC3-RPN4 9 3.62E-12
3 SGTC_2425 5628681 4.70 7.8 µM 6.03E-7 7 1.31E-6
4 SGTC_1030 k029-0042 4.60 36.7 µM 9.95E-7 TSC3-RPN4 11 2.09E-6
5 SGTC_2957 9076800 4.51 11.5 µM 1.56E-6 15 3.19E-6
6 SGTC_1311 1190-0148 4.25 100.0 µM 5.57E-6 azole & statin 23 1.05E-5
7 SGTC_2770 toltrazuril 4.22 17.5 µM 6.49E-6 20 1.22E-5
8 SGTC_299 1273-0059 4.20 1.4 µM 7.13E-6 23 1.33E-5
9 SGTC_1217 1183-1422 4.11 255.0 µM 1.11E-5 9 2.01E-5
10 SGTC_1225 1216-0074 3.93 20.6 µM 2.51E-5 24 4.34E-5
11 SGTC_2429 5902844 3.56 64.4 µM 1.18E-4 40 1.86E-4
12 SGTC_2514 salinomycin 3.35 42.7 µM 2.65E-4 84 3.97E-4
13 SGTC_2537 larixol 3.34 68.9 µM 2.77E-4 49 4.14E-4
14 SGTC_1089 terbinafine 3.27 2.2 µM 3.70E-4 36 5.43E-4
15 SGTC_831 k061-1017 3.21 217.0 µM 4.64E-4 translation 107 6.73E-4
16 SGTC_1605 st000082 3.17 49.1 µM 5.34E-4 60S ribosome export 54 7.69E-4
17 SGTC_1042 0350-0096 3.01 82.0 µM 9.38E-4 TSC3-RPN4 58 0.00131
18 SGTC_2453 5731132 2.99 22.2 µM 0.00101 71 0.00140
19 SGTC_929 2805-0021 2.93 398.0 µM 0.00125 65 0.00170
20 SGTC_2446 5162541 2.92 200.0 µM 0.00126 40 0.00173

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.404 1.20E-131 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.358 1.29E-101 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.342 3.54E-92 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.301 3.70E-71 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.279 4.92E-61 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.266 2.83E-55 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.265 6.77E-55 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.256 2.83E-51 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.238 2.25E-44 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.238 2.61E-44 YGL254W FZF1 hom Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress
0.226 6.90E-40 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.224 3.26E-39 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.220 4.62E-38 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
0.218 1.90E-37 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.213 1.07E-35 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C