YDL187C_d

Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL187C / YDL187C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.76|P-value:1.95E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:3.34|P-value:9.65E-4 ID:SGTC_500|Compound:h-89|FD-Score:5.31|P-value:3.83E-7 ID:SGTC_578|Compound:3460-0051|FD-Score:-3.32|P-value:8.61E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.47|P-value:5.35E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.65|P-value:2.91E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.13|P-value:6.18E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:-4.35|P-value:2.06E-5 ID:SGTC_1477|Compound:0139-0234|FD-Score:-4.46|P-value:1.33E-5 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.01|P-value:9.39E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-3.91|P-value:1.14E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.39|P-value:8.06E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.20|P-value:4.58E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.52|P-value:5.27E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.42|P-value:7.39E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-4.46|P-value:1.31E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-4.06|P-value:6.56E-5 ID:SGTC_2354|Compound:9060492|FD-Score:5.09|P-value:1.08E-6 ID:SGTC_2359|Compound:9039622|FD-Score:-4.97|P-value:1.48E-6 ID:SGTC_2360|Compound:9040895|FD-Score:-5.84|P-value:2.04E-8 ID:SGTC_2368|Compound:9071271|FD-Score:-3.73|P-value:2.21E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.31|P-value:8.92E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.48|P-value:6.18E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.61|P-value:3.37E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-4.19|P-value:3.92E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.94|P-value:1.25E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-4.18|P-value:4.19E-5 ID:SGTC_2478|Compound:5763493|FD-Score:-3.55|P-value:4.02E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.89|P-value:1.22E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.64|P-value:3.52E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.99|P-value:1.03E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.48|P-value:6.03E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.73|P-value:2.61E-4 ID:SGTC_3272|Compound:9137413|FD-Score:5.11|P-value:9.85E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.76|P-value:1.95E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:3.34|P-value:9.65E-4 ID:SGTC_500|Compound:h-89|FD-Score:5.31|P-value:3.83E-7 ID:SGTC_578|Compound:3460-0051|FD-Score:-3.32|P-value:8.61E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.47|P-value:5.35E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.65|P-value:2.91E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.13|P-value:6.18E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:-4.35|P-value:2.06E-5 ID:SGTC_1477|Compound:0139-0234|FD-Score:-4.46|P-value:1.33E-5 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.01|P-value:9.39E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-3.91|P-value:1.14E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.39|P-value:8.06E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.20|P-value:4.58E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.52|P-value:5.27E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.42|P-value:7.39E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-4.46|P-value:1.31E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-4.06|P-value:6.56E-5 ID:SGTC_2354|Compound:9060492|FD-Score:5.09|P-value:1.08E-6 ID:SGTC_2359|Compound:9039622|FD-Score:-4.97|P-value:1.48E-6 ID:SGTC_2360|Compound:9040895|FD-Score:-5.84|P-value:2.04E-8 ID:SGTC_2368|Compound:9071271|FD-Score:-3.73|P-value:2.21E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.31|P-value:8.92E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.48|P-value:6.18E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.61|P-value:3.37E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-4.19|P-value:3.92E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.94|P-value:1.25E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-4.18|P-value:4.19E-5 ID:SGTC_2478|Compound:5763493|FD-Score:-3.55|P-value:4.02E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.89|P-value:1.22E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.64|P-value:3.52E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.99|P-value:1.03E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.48|P-value:6.03E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.73|P-value:2.61E-4 ID:SGTC_3272|Compound:9137413|FD-Score:5.11|P-value:9.85E-7

Top fitness defect scores for YDL187C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_500 h-89 5.31 112.0 µM 3.83E-7 cell wall signaling 15 5.60E-8
2 SGTC_3272 9137413 5.11 49.5 µM 9.85E-7 3 1.65E-7
3 SGTC_2354 9060492 5.09 162.0 µM 1.08E-6 4 1.82E-7
4 SGTC_1855 st056195 4.20 39.6 µM 4.58E-5 60S ribosome export 11 1.31E-5
5 SGTC_1068 loratadine 4.13 26.9 µM 6.18E-5 18 1.85E-5
6 SGTC_1479 0549-0158 4.01 134.0 µM 9.39E-5 23 2.98E-5
7 SGTC_2635 hydroquinidine 3.99 100.0 µM 1.03E-4 24 3.31E-5
8 SGTC_2426 5582046 3.94 32.2 µM 1.25E-4 30 4.14E-5
9 SGTC_3247 9135149 3.73 49.5 µM 2.61E-4 DNA damage response 25 9.54E-5
10 SGTC_2563 tomatine 3.64 8.5 µM 3.52E-4 64 1.34E-4
11 SGTC_1941 st076221 3.52 61.8 µM 5.27E-4 sphingolipid biosynthesis & PDR1 99 2.13E-4
12 SGTC_2887 9044784 3.48 58.4 µM 6.03E-4 fatty acid desaturase (OLE1) 53 2.48E-4
13 SGTC_2398 5228213 3.48 48.8 µM 6.18E-4 iron homeostasis 56 2.55E-4
14 SGTC_2084 5306078 3.42 60.6 µM 7.39E-4 36 3.12E-4
15 SGTC_1728 st035614 3.39 33.8 µM 8.06E-4 84 3.45E-4
16 SGTC_298 1391-0729 3.34 10.0 µM 9.65E-4 calcium & mitochondrial duress 30 4.23E-4
17 SGTC_1979 st071809 3.26 45.3 µM 0.00123 RPP1 & pyrimidine depletion 40 5.59E-4
18 SGTC_127 0180-0333 3.22 59.1 µM 0.00138 mitochondrial response to ROS 83 6.34E-4
19 SGTC_2011 4012611 3.17 177.0 µM 0.00160 mitochondrial processes 58 7.49E-4
20 SGTC_2066 5222451 3.16 176.0 µM 0.00169 heme biosynthesis & mitochondrial translocase 69 7.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.75E-11 YBR239C_p ERT1_p hom Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition
0.087 4.30E-7 YNL253W TEX1 hom Protein involved in mRNA export, component of the transcription export (TREX) complex
0.085 7.35E-7 YDR221W GTB1 hom Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress
0.084 9.68E-7 YGR153W_p YGR153W_p hom Putative protein of unknown function
0.082 2.03E-6 YDR192C NUP42 hom FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p
0.081 2.98E-6 YHR125W_d YHR125W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.70E-6 YBL019W APN2 hom Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
0.079 5.09E-6 YMR155W_p YMR155W_p hom Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
0.077 7.79E-6 YER156C_p YER156C_p hom Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1
0.077 9.06E-6 YGR071C ENV11 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.077 9.08E-6 YDL241W_p YDL241W_p hom Putative protein of unknown function; YDL241W is not an essential gene
0.076 9.75E-6 YIL118W RHO3 het Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
0.076 1.15E-5 YNL301C RPL18B hom Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication
0.076 1.15E-5 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.075 1.37E-5 YMR018W_p YMR018W_p hom Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene