YDL188C / PPH22

Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL188C / PPH22

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:-3.17|P-value:7.83E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.27|P-value:5.39E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:8.64|P-value:2.95E-18 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.40|P-value:3.34E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.85|P-value:5.80E-5 ID:SGTC_476|Compound:mead acid|FD-Score:-3.67|P-value:1.24E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-4.05|P-value:2.62E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-4.81|P-value:7.61E-7 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.02|P-value:3.05E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.33|P-value:4.44E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.29|P-value:5.06E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.59|P-value:1.61E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.33|P-value:4.44E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.04|P-value:2.61E-5 ID:SGTC_1617|Compound:st002906|FD-Score:-3.16|P-value:8.15E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.96|P-value:3.65E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-5.20|P-value:1.05E-7 ID:SGTC_1987|Compound:st072290|FD-Score:-3.19|P-value:7.18E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.45|P-value:2.85E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.91|P-value:4.68E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.22|P-value:6.45E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.18|P-value:7.20E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.18|P-value:7.57E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.68|P-value:1.14E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.17|P-value:7.68E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.46|P-value:2.66E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.65|P-value:1.28E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.12|P-value:9.09E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.26|P-value:5.55E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.82|P-value:6.55E-5 ID:SGTC_3050|Compound:9093513|FD-Score:6.93|P-value:2.15E-12 ID:SGTC_3053|Compound:9095903|FD-Score:3.33|P-value:4.36E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.19|P-value:7.15E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.54|P-value:2.01E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.17|P-value:7.83E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.27|P-value:5.39E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:8.64|P-value:2.95E-18 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.40|P-value:3.34E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.85|P-value:5.80E-5 ID:SGTC_476|Compound:mead acid|FD-Score:-3.67|P-value:1.24E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-4.05|P-value:2.62E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-4.81|P-value:7.61E-7 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.02|P-value:3.05E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.33|P-value:4.44E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.29|P-value:5.06E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.59|P-value:1.61E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.33|P-value:4.44E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.04|P-value:2.61E-5 ID:SGTC_1617|Compound:st002906|FD-Score:-3.16|P-value:8.15E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.96|P-value:3.65E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-5.20|P-value:1.05E-7 ID:SGTC_1987|Compound:st072290|FD-Score:-3.19|P-value:7.18E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.45|P-value:2.85E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.91|P-value:4.68E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.22|P-value:6.45E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.18|P-value:7.20E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.18|P-value:7.57E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.68|P-value:1.14E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.17|P-value:7.68E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.46|P-value:2.66E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.65|P-value:1.28E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.12|P-value:9.09E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.26|P-value:5.55E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.82|P-value:6.55E-5 ID:SGTC_3050|Compound:9093513|FD-Score:6.93|P-value:2.15E-12 ID:SGTC_3053|Compound:9095903|FD-Score:3.33|P-value:4.36E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.19|P-value:7.15E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.54|P-value:2.01E-4

Top fitness defect scores for YDL188C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_453 enantio-paf c16 8.64 10.0 µM 2.95E-18 9 2.92E-18
2 SGTC_3050 9093513 6.93 49.5 µM 2.15E-12 4 2.14E-12
3 SGTC_1377 2944-0135 4.04 198.0 µM 2.61E-5 calcium & mitochondrial duress 34 2.63E-5
4 SGTC_1833 st055984 3.96 71.0 µM 3.65E-5 17 3.68E-5
5 SGTC_455 paf C-16 3.85 10.0 µM 5.80E-5 33 5.84E-5
6 SGTC_3046 9092212 3.82 49.5 µM 6.55E-5 8 6.59E-5
7 SGTC_2713 st079149 3.68 53.4 µM 1.14E-4 32 1.15E-4
8 SGTC_2799 7812892 3.65 81.8 µM 1.28E-4 superoxide 38 1.29E-4
9 SGTC_1133 3473-0247 3.59 50.0 µM 1.61E-4 RSC complex & mRNA processing 67 1.63E-4
10 SGTC_3228 9131799 3.54 49.5 µM 2.01E-4 amide catabolism 14 2.02E-4
11 SGTC_2797 7859098 3.46 81.8 µM 2.66E-4 42 2.68E-4
12 SGTC_454 lyso-paf C-16 3.40 6.7 µM 3.34E-4 39 3.36E-4
13 SGTC_3053 9095903 3.33 49.5 µM 4.36E-4 Golgi 12 4.39E-4
14 SGTC_1128 3448-9350 3.29 235.0 µM 5.06E-4 47 5.09E-4
15 SGTC_435 c-PAF 3.27 6.7 µM 5.39E-4 79 5.42E-4
16 SGTC_2987 9018338 3.26 71.4 µM 5.55E-4 RPP1 & pyrimidine depletion 47 5.59E-4
17 SGTC_3058 9093861 3.19 49.5 µM 7.15E-4 48 7.19E-4
18 SGTC_2436 5633522 3.18 8.1 µM 7.20E-4 40 7.25E-4
19 SGTC_2787 5284540 3.17 71.4 µM 7.68E-4 57 7.73E-4
20 SGTC_2923 7992654 3.12 58.1 µM 9.09E-4 Golgi 61 9.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.206 1.87E-33 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.187 1.22E-27 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.162 3.81E-21 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.146 1.65E-17 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.144 5.11E-17 YDL134C PPH21 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
0.141 1.95E-16 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.139 5.06E-16 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.138 1.16E-15 YKR033C_d YKR033C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
0.127 1.62E-13 YGR100W MDR1 hom Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
0.123 7.38E-13 YBR224W_d YBR224W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
0.122 1.48E-12 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.121 1.85E-12 YJR067C YAE1 het Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.120 3.41E-12 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.120 3.80E-12 YKL121W_p DGR2_p hom Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds
0.119 4.77E-12 YDR045C RPC11 het RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS