YDL191W / RPL35A

Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL191W / RPL35A

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-4.68|P-value:1.04E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:6.62|P-value:1.29E-11 ID:SGTC_70|Compound:0141-0289|FD-Score:6.20|P-value:2.06E-10 ID:SGTC_72|Compound:0744-0168|FD-Score:4.13|P-value:1.62E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.97|P-value:7.32E-10 ID:SGTC_76|Compound:0433-0009|FD-Score:-4.19|P-value:1.07E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:3.72|P-value:9.05E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.59|P-value:1.37E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.43|P-value:2.81E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.12|P-value:7.76E-4 ID:SGTC_446|Compound:go6976|FD-Score:5.72|P-value:4.13E-9 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.58|P-value:8.17E-9 ID:SGTC_581|Compound:0958-0271|FD-Score:3.24|P-value:5.57E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.28|P-value:8.15E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:5.67|P-value:5.52E-9 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.27|P-value:4.60E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.23|P-value:1.05E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.00|P-value:2.83E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.10|P-value:9.25E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-6.21|P-value:1.61E-10 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-8.32|P-value:1.89E-17 ID:SGTC_1088|Compound:bifonazole|FD-Score:-5.39|P-value:2.36E-8 ID:SGTC_1089|Compound:terbinafine|FD-Score:-8.33|P-value:1.79E-17 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.58|P-value:1.95E-6 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.11|P-value:8.89E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.81|P-value:6.35E-5 ID:SGTC_1676|Compound:st018489|FD-Score:3.20|P-value:6.54E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.14|P-value:8.08E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.91|P-value:3.81E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.13|P-value:7.49E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.14|P-value:7.82E-4 ID:SGTC_1750|Compound:st081859|FD-Score:8.01|P-value:3.34E-16 ID:SGTC_1871|Compound:st057448|FD-Score:3.12|P-value:8.66E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.11|P-value:8.68E-4 ID:SGTC_1944|Compound:st076371|FD-Score:5.28|P-value:5.30E-8 ID:SGTC_2054|Compound:5233173|FD-Score:-3.27|P-value:4.50E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.40|P-value:3.15E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.30|P-value:4.58E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.44|P-value:3.96E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.68|P-value:1.08E-4 ID:SGTC_2335|Compound:9018011|FD-Score:4.72|P-value:1.01E-6 ID:SGTC_2337|Compound:9009472|FD-Score:3.67|P-value:1.10E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.09|P-value:9.51E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.31|P-value:4.36E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.43|P-value:2.77E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.12|P-value:8.58E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.26|P-value:9.06E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.71|P-value:9.30E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:3.72|P-value:9.25E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.99|P-value:3.00E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.38|P-value:3.40E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:6.96|P-value:1.14E-12 ID:SGTC_2829|Compound:7992743|FD-Score:4.05|P-value:2.24E-5 ID:SGTC_2947|Compound:9072639|FD-Score:-4.25|P-value:8.34E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.07|P-value:9.99E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.16|P-value:1.40E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.89|P-value:4.56E-5 ID:SGTC_2995|Compound:9067767|FD-Score:4.73|P-value:9.54E-7 ID:SGTC_3161|Compound:9100388|FD-Score:-3.13|P-value:7.35E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.68|P-value:1.04E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:6.62|P-value:1.29E-11 ID:SGTC_70|Compound:0141-0289|FD-Score:6.20|P-value:2.06E-10 ID:SGTC_72|Compound:0744-0168|FD-Score:4.13|P-value:1.62E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.97|P-value:7.32E-10 ID:SGTC_76|Compound:0433-0009|FD-Score:-4.19|P-value:1.07E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:3.72|P-value:9.05E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.59|P-value:1.37E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.43|P-value:2.81E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.12|P-value:7.76E-4 ID:SGTC_446|Compound:go6976|FD-Score:5.72|P-value:4.13E-9 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.58|P-value:8.17E-9 ID:SGTC_581|Compound:0958-0271|FD-Score:3.24|P-value:5.57E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.28|P-value:8.15E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:5.67|P-value:5.52E-9 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.27|P-value:4.60E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.23|P-value:1.05E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.00|P-value:2.83E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.10|P-value:9.25E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-6.21|P-value:1.61E-10 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-8.32|P-value:1.89E-17 ID:SGTC_1088|Compound:bifonazole|FD-Score:-5.39|P-value:2.36E-8 ID:SGTC_1089|Compound:terbinafine|FD-Score:-8.33|P-value:1.79E-17 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.58|P-value:1.95E-6 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.11|P-value:8.89E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.81|P-value:6.35E-5 ID:SGTC_1676|Compound:st018489|FD-Score:3.20|P-value:6.54E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.14|P-value:8.08E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.91|P-value:3.81E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.13|P-value:7.49E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.14|P-value:7.82E-4 ID:SGTC_1750|Compound:st081859|FD-Score:8.01|P-value:3.34E-16 ID:SGTC_1871|Compound:st057448|FD-Score:3.12|P-value:8.66E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.11|P-value:8.68E-4 ID:SGTC_1944|Compound:st076371|FD-Score:5.28|P-value:5.30E-8 ID:SGTC_2054|Compound:5233173|FD-Score:-3.27|P-value:4.50E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.40|P-value:3.15E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.30|P-value:4.58E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.44|P-value:3.96E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.68|P-value:1.08E-4 ID:SGTC_2335|Compound:9018011|FD-Score:4.72|P-value:1.01E-6 ID:SGTC_2337|Compound:9009472|FD-Score:3.67|P-value:1.10E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.09|P-value:9.51E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.31|P-value:4.36E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.43|P-value:2.77E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.12|P-value:8.58E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.26|P-value:9.06E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.71|P-value:9.30E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:3.72|P-value:9.25E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.99|P-value:3.00E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.38|P-value:3.40E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:6.96|P-value:1.14E-12 ID:SGTC_2829|Compound:7992743|FD-Score:4.05|P-value:2.24E-5 ID:SGTC_2947|Compound:9072639|FD-Score:-4.25|P-value:8.34E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.07|P-value:9.99E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.16|P-value:1.40E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.89|P-value:4.56E-5 ID:SGTC_2995|Compound:9067767|FD-Score:4.73|P-value:9.54E-7 ID:SGTC_3161|Compound:9100388|FD-Score:-3.13|P-value:7.35E-4

Top fitness defect scores for YDL191W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 8.01 2.4 µM 3.34E-16 endomembrane recycling 68 5.79E-16
2 SGTC_2756 carbadox 6.96 75.1 µM 1.14E-12 12 1.71E-12
3 SGTC_66 0109-0187 6.62 42.4 µM 1.29E-11 9 1.86E-11
4 SGTC_70 0141-0289 6.20 43.3 µM 2.06E-10 mitochondrial stress 74 2.81E-10
5 SGTC_446 go6976 5.72 132.0 µM 4.13E-9 3 5.36E-9
6 SGTC_800 3448-7362 5.67 155.0 µM 5.52E-9 translation 60 7.12E-9
7 SGTC_1944 st076371 5.28 56.9 µM 5.30E-8 8 6.58E-8
8 SGTC_1695 st026914 4.91 34.5 µM 3.81E-7 4 4.57E-7
9 SGTC_2995 9067767 4.73 71.4 µM 9.54E-7 13 1.13E-6
10 SGTC_2335 9018011 4.72 154.2 µM 1.01E-6 18 1.20E-6
11 SGTC_1134 3477-0009 4.58 42.5 µM 1.95E-6 28 2.28E-6
12 SGTC_2277 7947813 4.44 106.9 µM 3.96E-6 RSC complex & mRNA processing 17 4.57E-6
13 SGTC_710 3448-4187 4.28 58.0 µM 8.15E-6 fatty acid desaturase (OLE1) 49 9.31E-6
14 SGTC_2489 cantharidin 4.26 73.4 µM 9.06E-6 cell wall signaling 35 1.03E-5
15 SGTC_1047 2043-3044 4.23 82.0 µM 1.05E-5 25 1.19E-5
16 SGTC_2989 9073649 4.16 71.4 µM 1.40E-5 29 1.58E-5
17 SGTC_72 0744-0168 4.13 198.4 µM 1.62E-5 RPP1 & pyrimidine depletion 26 1.82E-5
18 SGTC_2829 7992743 4.05 58.4 µM 2.24E-5 32 2.52E-5
19 SGTC_1051 3253-3903 4.00 78.0 µM 2.83E-5 25 3.17E-5
20 SGTC_2626 ethyl orsellinate 3.99 100.0 µM 3.00E-5 34 3.35E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 7.41E-27 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.151 1.79E-18 YPR153W YPR153W hom Putative protein of unknown function
0.148 7.08E-18 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.131 2.61E-14 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.129 5.24E-14 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.128 1.01E-13 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.125 3.74E-13 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.122 1.56E-12 YJR105W ADO1 hom Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
0.118 7.44E-12 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.113 5.95E-11 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.111 1.21E-10 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107 6.06E-10 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.106 7.82E-10 YDR529C QCR7 hom Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
0.102 2.62E-9 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.102 3.84E-9 YDL194W SNF3 hom Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication