YDL193W / NUS1

Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL193W / NUS1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.51|P-value:2.15E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:5.85|P-value:2.85E-6 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:4.28|P-value:4.74E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:4.18|P-value:6.16E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:4.39|P-value:3.44E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.44|P-value:9.28E-6 ID:SGTC_263|Compound:alizarin|FD-Score:-4.46|P-value:2.19E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:4.24|P-value:5.27E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.62|P-value:1.34E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-5.10|P-value:2.93E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.99|P-value:4.30E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:-4.72|P-value:9.91E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-6.48|P-value:1.73E-7 ID:SGTC_356|Compound:1634-0012|FD-Score:5.19|P-value:2.86E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-5.26|P-value:1.72E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:5.05|P-value:4.53E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:4.29|P-value:4.57E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.28|P-value:4.68E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.57|P-value:1.58E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:5.55|P-value:8.45E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:5.07|P-value:4.37E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:-5.30|P-value:1.53E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-5.62|P-value:4.87E-6 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.29|P-value:4.60E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.93|P-value:5.23E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-5.16|P-value:2.44E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.20|P-value:2.79E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:-5.25|P-value:1.81E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:-4.89|P-value:5.86E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.12|P-value:3.62E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-4.49|P-value:2.00E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.25|P-value:6.24E-7 ID:SGTC_1754|Compound:st042065|FD-Score:-4.02|P-value:7.48E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.67|P-value:1.17E-4 ID:SGTC_1791|Compound:st048313|FD-Score:6.23|P-value:6.80E-7 ID:SGTC_1920|Compound:st075728|FD-Score:-4.07|P-value:6.69E-4 ID:SGTC_1921|Compound:5740136|FD-Score:6.33|P-value:4.52E-7 ID:SGTC_1922|Compound:5578187|FD-Score:6.63|P-value:1.35E-7 ID:SGTC_1924|Compound:st058459|FD-Score:-7.87|P-value:3.26E-10 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.39|P-value:2.66E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.75|P-value:1.19E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-6.83|P-value:4.06E-8 ID:SGTC_2225|Compound:6654152|FD-Score:4.31|P-value:4.31E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.05|P-value:8.84E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-6.11|P-value:7.76E-7 ID:SGTC_2307|Compound:7538926|FD-Score:5.42|P-value:1.32E-5 ID:SGTC_2340|Compound:7987427|FD-Score:4.28|P-value:4.72E-4 ID:SGTC_2345|Compound:9052315|FD-Score:4.51|P-value:2.46E-4 ID:SGTC_2363|Compound:9053361|FD-Score:-5.03|P-value:3.69E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.28|P-value:3.70E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.91|P-value:7.12E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.01|P-value:5.23E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-5.60|P-value:5.18E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:-6.05|P-value:9.88E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.61|P-value:1.41E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:4.28|P-value:4.68E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.53|P-value:2.27E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-5.23|P-value:1.90E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.66|P-value:1.55E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.23|P-value:4.20E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.34|P-value:3.97E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.23|P-value:5.42E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-4.27|P-value:3.75E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.23|P-value:5.44E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-4.19|P-value:4.80E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.54|P-value:1.75E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-4.97|P-value:4.50E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-5.08|P-value:3.15E-5 ID:SGTC_3178|Compound:9107506|FD-Score:5.57|P-value:8.04E-6 ID:SGTC_3200|Compound:9114385|FD-Score:4.17|P-value:6.26E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.45|P-value:2.86E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.99|P-value:4.25E-5 ID:SGTC_3243|Compound:9134147|FD-Score:-5.54|P-value:6.46E-6 ID:SGTC_3252|Compound:9135871|FD-Score:4.72|P-value:1.30E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.51|P-value:2.15E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:5.85|P-value:2.85E-6 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:4.28|P-value:4.74E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:4.18|P-value:6.16E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:4.39|P-value:3.44E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.44|P-value:9.28E-6 ID:SGTC_263|Compound:alizarin|FD-Score:-4.46|P-value:2.19E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:4.24|P-value:5.27E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.62|P-value:1.34E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-5.10|P-value:2.93E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.99|P-value:4.30E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:-4.72|P-value:9.91E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-6.48|P-value:1.73E-7 ID:SGTC_356|Compound:1634-0012|FD-Score:5.19|P-value:2.86E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-5.26|P-value:1.72E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:5.05|P-value:4.53E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:4.29|P-value:4.57E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.28|P-value:4.68E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.57|P-value:1.58E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:5.55|P-value:8.45E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:5.07|P-value:4.37E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:-5.30|P-value:1.53E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-5.62|P-value:4.87E-6 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.29|P-value:4.60E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.93|P-value:5.23E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-5.16|P-value:2.44E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.20|P-value:2.79E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:-5.25|P-value:1.81E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:-4.89|P-value:5.86E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.12|P-value:3.62E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-4.49|P-value:2.00E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.25|P-value:6.24E-7 ID:SGTC_1754|Compound:st042065|FD-Score:-4.02|P-value:7.48E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.67|P-value:1.17E-4 ID:SGTC_1791|Compound:st048313|FD-Score:6.23|P-value:6.80E-7 ID:SGTC_1920|Compound:st075728|FD-Score:-4.07|P-value:6.69E-4 ID:SGTC_1921|Compound:5740136|FD-Score:6.33|P-value:4.52E-7 ID:SGTC_1922|Compound:5578187|FD-Score:6.63|P-value:1.35E-7 ID:SGTC_1924|Compound:st058459|FD-Score:-7.87|P-value:3.26E-10 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.39|P-value:2.66E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.75|P-value:1.19E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-6.83|P-value:4.06E-8 ID:SGTC_2225|Compound:6654152|FD-Score:4.31|P-value:4.31E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.05|P-value:8.84E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-6.11|P-value:7.76E-7 ID:SGTC_2307|Compound:7538926|FD-Score:5.42|P-value:1.32E-5 ID:SGTC_2340|Compound:7987427|FD-Score:4.28|P-value:4.72E-4 ID:SGTC_2345|Compound:9052315|FD-Score:4.51|P-value:2.46E-4 ID:SGTC_2363|Compound:9053361|FD-Score:-5.03|P-value:3.69E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.28|P-value:3.70E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.91|P-value:7.12E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.01|P-value:5.23E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-5.60|P-value:5.18E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:-6.05|P-value:9.88E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.61|P-value:1.41E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:4.28|P-value:4.68E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.53|P-value:2.27E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-5.23|P-value:1.90E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.66|P-value:1.55E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.23|P-value:4.20E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.34|P-value:3.97E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.23|P-value:5.42E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-4.27|P-value:3.75E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.23|P-value:5.44E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-4.19|P-value:4.80E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.54|P-value:1.75E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-4.97|P-value:4.50E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-5.08|P-value:3.15E-5 ID:SGTC_3178|Compound:9107506|FD-Score:5.57|P-value:8.04E-6 ID:SGTC_3200|Compound:9114385|FD-Score:4.17|P-value:6.26E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.45|P-value:2.86E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.99|P-value:4.25E-5 ID:SGTC_3243|Compound:9134147|FD-Score:-5.54|P-value:6.46E-6 ID:SGTC_3252|Compound:9135871|FD-Score:4.72|P-value:1.30E-4

Top fitness defect scores for YDL193W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1922 5578187 6.63 25.0 µM 1.35E-7 TRP & mitochondrial translation 4 1.70E-11 1.57
2 SGTC_10 0279-0212 6.51 42.6 µM 2.15E-7 TRP & mitochondrial translation 3 3.64E-11 0.88
3 SGTC_1921 5740136 6.33 50.0 µM 4.52E-7 TRP & mitochondrial translation 3 1.22E-10 0.05
4 SGTC_1742 st038235 6.25 28.9 µM 6.24E-7 mitochondrial stress 3 2.06E-10 1.38
5 SGTC_1791 st048313 6.23 56.1 µM 6.80E-7 1 2.36E-10 1.40
6 SGTC_19 0279-0214 5.85 38.4 µM 2.85E-6 TRP & mitochondrial translation 2 2.43E-9 0.23
7 SGTC_3178 9107506 5.57 49.5 µM 8.04E-6 2 1.31E-8 0.56
8 SGTC_748 0136-0228 5.55 77.9 µM 8.45E-6 redox potentiating 5 1.42E-8 1.35
9 SGTC_2307 7538926 5.42 6.3 µM 1.32E-5 10 2.91E-8 0.07
10 SGTC_1319 1306-0155 5.20 43.7 µM 2.79E-5 5 9.82E-8 1.44
11 SGTC_356 1634-0012 5.19 32.5 µM 2.86E-5 2 1.03E-7 0.01
12 SGTC_1513 0337-0559 5.12 19.0 µM 3.62E-5 3 1.50E-7 0.10
13 SGTC_767 0929-0023 5.07 86.0 µM 4.37E-5 TRP & mitochondrial translation 6 2.04E-7 0.17
14 SGTC_415 dibenzyl ketone 5.05 100.0 µM 4.53E-5 1 2.16E-7 0.81
15 SGTC_2454 5-benzylidenerhodanine 5.01 10.4 µM 5.23E-5 TRP & mitochondrial translation 2 2.73E-7 1.08
16 SGTC_2444 5485484 4.91 36.4 µM 7.12E-5 2 4.48E-7 0.08
17 SGTC_1931 st074438 4.75 57.1 µM 1.19E-4 3 1.03E-6 0.22
18 SGTC_3252 9135871 4.72 49.5 µM 1.30E-4 3 1.19E-6 0.27
19 SGTC_2921 7974240 4.66 10.7 µM 1.55E-4 11 1.57E-6 0.17
20 SGTC_2759 disulfiram 4.53 3.4 µM 2.27E-4 11 2.93E-6 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.370 1.03E-108 YBR002C RER2 het Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
0.228 1.41E-40 YIL026C IRR1 het Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
0.209 2.00E-34 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.174 3.14E-24 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.173 8.03E-24 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.170 3.26E-23 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.170 3.44E-23 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii
0.168 1.21E-22 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.168 1.30E-22 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.164 1.11E-21 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.162 3.51E-21 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.160 1.18E-20 YIL060W_p YIL060W_p hom Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene
0.157 8.62E-20 YEL050C RML2 hom Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
0.156 1.39E-19 YBR004C GPI18 het Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
0.155 1.43E-19 YBR039W ATP3 hom Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis