YDL198C / GGC1

Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL198C / GGC1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.38|P-value:4.75E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.64|P-value:2.67E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.61|P-value:2.07E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.24|P-value:7.56E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.23|P-value:7.93E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.86|P-value:7.89E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:7.94|P-value:3.27E-15 ID:SGTC_159|Compound:3970-0959|FD-Score:5.97|P-value:2.35E-9 ID:SGTC_168|Compound:3970-0862|FD-Score:3.70|P-value:1.43E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:8.38|P-value:9.65E-17 ID:SGTC_211|Compound:3455-0679|FD-Score:4.28|P-value:1.40E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:8.05|P-value:1.35E-15 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.01|P-value:1.85E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:6.63|P-value:3.79E-11 ID:SGTC_327|Compound:1273-0057|FD-Score:3.77|P-value:1.12E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.70|P-value:1.80E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.98|P-value:4.19E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:-5.16|P-value:1.83E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:4.09|P-value:3.05E-5 ID:SGTC_433|Compound:pimozide|FD-Score:4.38|P-value:8.91E-6 ID:SGTC_444|Compound:curcumin|FD-Score:-3.91|P-value:5.69E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.33|P-value:5.49E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.81|P-value:8.32E-5 ID:SGTC_458|Compound:nppb|FD-Score:3.74|P-value:1.27E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:4.02|P-value:4.06E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:3.51|P-value:2.98E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.18|P-value:8.29E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:-3.42|P-value:3.61E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.40|P-value:4.41E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.19|P-value:9.09E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:4.03|P-value:3.90E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.08|P-value:3.18E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.12|P-value:2.76E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.17|P-value:2.21E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.79|P-value:9.23E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.71|P-value:1.96E-6 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.37|P-value:4.92E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.93|P-value:6.72E-7 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.90|P-value:5.92E-5 ID:SGTC_1635|Compound:st007035|FD-Score:6.90|P-value:6.37E-12 ID:SGTC_1687|Compound:st020778|FD-Score:3.27|P-value:6.82E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.28|P-value:1.39E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.92|P-value:6.17E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.19|P-value:8.90E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.16|P-value:9.12E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-5.14|P-value:1.96E-7 ID:SGTC_2010|Compound:4012422|FD-Score:3.77|P-value:1.10E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.53|P-value:2.77E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.71|P-value:1.25E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.30|P-value:5.59E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.82|P-value:9.19E-5 ID:SGTC_2113|Compound:5491891|FD-Score:4.52|P-value:4.64E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.49|P-value:2.80E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.77|P-value:1.49E-6 ID:SGTC_2297|Compound:7971671|FD-Score:3.59|P-value:2.20E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.30|P-value:6.12E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.06|P-value:3.42E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.48|P-value:3.30E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:4.89|P-value:8.34E-7 ID:SGTC_2570|Compound:licareol|FD-Score:6.32|P-value:2.78E-10 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.06|P-value:3.49E-7 ID:SGTC_2844|Compound:9010103|FD-Score:4.18|P-value:2.11E-5 ID:SGTC_2851|Compound:9015922|FD-Score:-3.38|P-value:4.14E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.73|P-value:1.14E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.75|P-value:1.37E-6 ID:SGTC_3068|Compound:9116768|FD-Score:3.43|P-value:3.94E-4 ID:SGTC_3186|Compound:9110464|FD-Score:-3.36|P-value:4.53E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.80|P-value:9.78E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:3.38|P-value:4.75E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.64|P-value:2.67E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.61|P-value:2.07E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.24|P-value:7.56E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.23|P-value:7.93E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.86|P-value:7.89E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:7.94|P-value:3.27E-15 ID:SGTC_159|Compound:3970-0959|FD-Score:5.97|P-value:2.35E-9 ID:SGTC_168|Compound:3970-0862|FD-Score:3.70|P-value:1.43E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:8.38|P-value:9.65E-17 ID:SGTC_211|Compound:3455-0679|FD-Score:4.28|P-value:1.40E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:8.05|P-value:1.35E-15 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.01|P-value:1.85E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:6.63|P-value:3.79E-11 ID:SGTC_327|Compound:1273-0057|FD-Score:3.77|P-value:1.12E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.70|P-value:1.80E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.98|P-value:4.19E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:-5.16|P-value:1.83E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:4.09|P-value:3.05E-5 ID:SGTC_433|Compound:pimozide|FD-Score:4.38|P-value:8.91E-6 ID:SGTC_444|Compound:curcumin|FD-Score:-3.91|P-value:5.69E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.33|P-value:5.49E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.81|P-value:8.32E-5 ID:SGTC_458|Compound:nppb|FD-Score:3.74|P-value:1.27E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:4.02|P-value:4.06E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:3.51|P-value:2.98E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.18|P-value:8.29E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:-3.42|P-value:3.61E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.40|P-value:4.41E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.19|P-value:9.09E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:4.03|P-value:3.90E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.08|P-value:3.18E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.12|P-value:2.76E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.17|P-value:2.21E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.79|P-value:9.23E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.71|P-value:1.96E-6 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.37|P-value:4.92E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.93|P-value:6.72E-7 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.90|P-value:5.92E-5 ID:SGTC_1635|Compound:st007035|FD-Score:6.90|P-value:6.37E-12 ID:SGTC_1687|Compound:st020778|FD-Score:3.27|P-value:6.82E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.28|P-value:1.39E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.92|P-value:6.17E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.19|P-value:8.90E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.16|P-value:9.12E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-5.14|P-value:1.96E-7 ID:SGTC_2010|Compound:4012422|FD-Score:3.77|P-value:1.10E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.53|P-value:2.77E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.71|P-value:1.25E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.30|P-value:5.59E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.82|P-value:9.19E-5 ID:SGTC_2113|Compound:5491891|FD-Score:4.52|P-value:4.64E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.49|P-value:2.80E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.77|P-value:1.49E-6 ID:SGTC_2297|Compound:7971671|FD-Score:3.59|P-value:2.20E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.30|P-value:6.12E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.06|P-value:3.42E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.48|P-value:3.30E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:4.89|P-value:8.34E-7 ID:SGTC_2570|Compound:licareol|FD-Score:6.32|P-value:2.78E-10 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.06|P-value:3.49E-7 ID:SGTC_2844|Compound:9010103|FD-Score:4.18|P-value:2.11E-5 ID:SGTC_2851|Compound:9015922|FD-Score:-3.38|P-value:4.14E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.73|P-value:1.14E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.75|P-value:1.37E-6 ID:SGTC_3068|Compound:9116768|FD-Score:3.43|P-value:3.94E-4 ID:SGTC_3186|Compound:9110464|FD-Score:-3.36|P-value:4.53E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.80|P-value:9.78E-5

Top fitness defect scores for YDL198C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 8.38 2.7 µM 9.65E-17 mitochondrial stress 59 2.64E-17
2 SGTC_236 1509-0011 8.05 5.3 µM 1.35E-15 249 4.06E-16
3 SGTC_156 3474-0145 7.94 5.6 µM 3.27E-15 endomembrane recycling 10 1.01E-15
4 SGTC_1635 st007035 6.90 42.4 µM 6.37E-12 119 2.58E-12
5 SGTC_310 1273-0058 6.63 1.1 µM 3.79E-11 mitochondrial stress 128 1.64E-11
6 SGTC_2570 licareol 6.32 100.0 µM 2.78E-10 4 1.29E-10
7 SGTC_275 trichlorophene 6.01 5.7 µM 1.85E-9 mitochondrial stress 118 9.20E-10
8 SGTC_159 3970-0959 5.97 50.0 µM 2.35E-9 26 1.18E-9
9 SGTC_2682 pyrogallin 5.06 40.0 µM 3.49E-7 copper-dependent oxidative stress 11 2.09E-7
10 SGTC_1521 st012942 4.93 49.4 µM 6.72E-7 13 4.12E-7
11 SGTC_2513 baicalein 4.89 25.6 µM 8.34E-7 calcium & mitochondrial duress 12 5.15E-7
12 SGTC_2250 alverine citrate 4.77 130.0 µM 1.49E-6 105 9.39E-7
13 SGTC_1188 1403-0014 4.71 4.6 µM 1.96E-6 mitochondrial stress 35 1.25E-6
14 SGTC_54 0159-0055 4.64 9.0 µM 2.67E-6 ERG2 33 1.72E-6
15 SGTC_2113 5491891 4.52 107.0 µM 4.64E-6 TSC3-RPN4 8 3.05E-6
16 SGTC_433 pimozide 4.38 108.0 µM 8.91E-6 12 5.99E-6
17 SGTC_1834 st055981 4.28 52.8 µM 1.39E-5 RPP1 & pyrimidine depletion 27 9.46E-6
18 SGTC_211 3455-0679 4.28 143.5 µM 1.40E-5 12 9.53E-6
19 SGTC_2844 9010103 4.18 26.0 µM 2.11E-5 28 1.46E-5
20 SGTC_1113 artemisinin 4.17 1.2 µM 2.21E-5 heme biosynthesis & mitochondrial translocase 11 1.53E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.453 6.01E-169 YLR369W SSQ1 hom Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia
0.403 6.29E-131 YGR257C MTM1 hom Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
0.398 8.21E-128 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.389 1.15E-121 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.384 4.99E-118 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.366 1.19E-106 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.360 4.44E-103 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.357 2.90E-101 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.357 4.29E-101 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.356 9.19E-101 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.356 1.54E-100 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.351 8.47E-98 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
0.350 2.16E-97 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.343 2.84E-93 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.340 2.23E-91 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit