YDL200C / MGT1

DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL200C / MGT1

Click on Significant Values for Screen Details ID:SGTC_166|Compound:k072-0058|FD-Score:3.56|P-value:5.65E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.65|P-value:4.21E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.51|P-value:6.67E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.54|P-value:1.69E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.74|P-value:7.39E-6 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.45|P-value:7.96E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.72|P-value:3.41E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.46|P-value:7.88E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.52|P-value:6.41E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.38|P-value:3.02E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.72|P-value:3.26E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.56|P-value:5.69E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.78|P-value:2.74E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.98|P-value:1.38E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.75|P-value:3.10E-4 ID:SGTC_1659|Compound:st012954|FD-Score:3.64|P-value:4.46E-4 ID:SGTC_1770|Compound:st043884|FD-Score:4.03|P-value:1.14E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.86|P-value:2.14E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.88|P-value:1.94E-4 ID:SGTC_2366|Compound:9070441|FD-Score:5.00|P-value:2.47E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.63|P-value:4.60E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.12|P-value:8.29E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.38|P-value:3.11E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.06|P-value:1.04E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.41|P-value:2.81E-5 ID:SGTC_2919|Compound:7978188|FD-Score:-3.48|P-value:7.29E-4 ID:SGTC_2923|Compound:7992654|FD-Score:5.21|P-value:9.86E-7 ID:SGTC_2924|Compound:9010168|FD-Score:4.31|P-value:4.04E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-3.58|P-value:5.22E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.32|P-value:3.95E-5 ID:SGTC_3072|Compound:9116419|FD-Score:4.19|P-value:6.55E-5 ID:SGTC_3159|Compound:9100096|FD-Score:3.74|P-value:3.20E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.52|P-value:6.41E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-6.91|P-value:1.28E-10 ID:SGTC_3216|Compound:9129716|FD-Score:-6.89|P-value:1.44E-10 ID:SGTC_3221|Compound:9128209|FD-Score:3.66|P-value:4.14E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.85|P-value:2.11E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.56|P-value:5.65E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.65|P-value:4.21E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.51|P-value:6.67E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.54|P-value:1.69E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.74|P-value:7.39E-6 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.45|P-value:7.96E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.72|P-value:3.41E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.46|P-value:7.88E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.52|P-value:6.41E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.38|P-value:3.02E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.72|P-value:3.26E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.56|P-value:5.69E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.78|P-value:2.74E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.98|P-value:1.38E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.75|P-value:3.10E-4 ID:SGTC_1659|Compound:st012954|FD-Score:3.64|P-value:4.46E-4 ID:SGTC_1770|Compound:st043884|FD-Score:4.03|P-value:1.14E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.86|P-value:2.14E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.88|P-value:1.94E-4 ID:SGTC_2366|Compound:9070441|FD-Score:5.00|P-value:2.47E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.63|P-value:4.60E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.12|P-value:8.29E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.38|P-value:3.11E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.06|P-value:1.04E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.41|P-value:2.81E-5 ID:SGTC_2919|Compound:7978188|FD-Score:-3.48|P-value:7.29E-4 ID:SGTC_2923|Compound:7992654|FD-Score:5.21|P-value:9.86E-7 ID:SGTC_2924|Compound:9010168|FD-Score:4.31|P-value:4.04E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-3.58|P-value:5.22E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.32|P-value:3.95E-5 ID:SGTC_3072|Compound:9116419|FD-Score:4.19|P-value:6.55E-5 ID:SGTC_3159|Compound:9100096|FD-Score:3.74|P-value:3.20E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.52|P-value:6.41E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-6.91|P-value:1.28E-10 ID:SGTC_3216|Compound:9129716|FD-Score:-6.89|P-value:1.44E-10 ID:SGTC_3221|Compound:9128209|FD-Score:3.66|P-value:4.14E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.85|P-value:2.11E-4

Top fitness defect scores for YDL200C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2923 7992654 5.21 58.1 µM 9.86E-7 Golgi 8 9.69E-8
2 SGTC_2366 9070441 5.00 60.6 µM 2.47E-6 11 2.89E-7
3 SGTC_572 0960-0087 4.74 17.7 µM 7.39E-6 13 1.06E-6
4 SGTC_517 1365-0151 4.54 113.0 µM 1.69E-5 23 2.84E-6
5 SGTC_2777 climbazole 4.41 1.5 µM 2.81E-5 iron homeostasis 34 5.21E-6
6 SGTC_2666 tannic acid 4.38 100.0 µM 3.11E-5 iron homeostasis 29 5.87E-6
7 SGTC_2991 9074669 4.32 71.4 µM 3.95E-5 azole & statin 48 7.78E-6
8 SGTC_2924 9010168 4.31 62.8 µM 4.04E-5 cell wall signaling 29 8.01E-6
9 SGTC_3072 9116419 4.19 49.5 µM 6.55E-5 ERG2 11 1.42E-5
10 SGTC_2675 theaflavin digallate 4.06 100.0 µM 1.04E-4 iron homeostasis 30 2.45E-5
11 SGTC_1770 st043884 4.03 66.3 µM 1.14E-4 12 2.74E-5
12 SGTC_1341 1486-1360 3.98 280.0 µM 1.38E-4 24 3.44E-5
13 SGTC_2203 7227154 3.88 166.4 µM 1.94E-4 15 5.13E-5
14 SGTC_1855 st056195 3.86 39.6 µM 2.14E-4 60S ribosome export 21 5.77E-5
15 SGTC_1197 1601-0112 3.78 267.0 µM 2.74E-4 24 7.74E-5
16 SGTC_1419 3993-2473 3.75 62.6 µM 3.10E-4 21 8.97E-5
17 SGTC_3159 9100096 3.74 49.5 µM 3.20E-4 27 9.31E-5
18 SGTC_918 glabranin 3.72 770.7 nM 3.41E-4 40 1.00E-4
19 SGTC_3221 9128209 3.66 49.5 µM 4.14E-4 22 1.26E-4
20 SGTC_196 k015-0023 3.65 18.1 µM 4.21E-4 PDR1 30 1.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 5.76E-22 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.103 2.19E-9 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.090 1.72E-7 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.090 2.07E-7 YER106W MAM1 hom Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
0.088 3.20E-7 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.085 7.13E-7 YDR045C RPC11 het RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
0.085 7.59E-7 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.082 1.93E-6 YGL041C-B_p YGL041C-B_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.079 4.53E-6 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.077 9.26E-6 YGR069W_d YGR069W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.075 1.36E-5 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.073 2.36E-5 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.073 2.67E-5 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.072 3.19E-5 YEL041W YEF1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication
0.069 6.29E-5 YDL135C RDI1 hom Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress