DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDL200C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.165 | 5.76E-22 | YDR382W | RPP2B | hom | Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm |
0.103 | 2.19E-9 | YFR042W | KEG1 | het | Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability |
0.090 | 1.72E-7 | YDL197C | ASF2 | hom | Anti-silencing protein that causes derepression of silent loci when overexpressed |
0.090 | 2.07E-7 | YER106W | MAM1 | hom | Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle |
0.088 | 3.20E-7 | YAL043C | PTA1 | het | Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII |
0.085 | 7.13E-7 | YDR045C | RPC11 | het | RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS |
0.085 | 7.59E-7 | YDL199C_p | YDL199C_p | hom | Putative transporter, member of the sugar porter family |
0.082 | 1.93E-6 | YGL041C-B_p | YGL041C-B_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |
0.079 | 4.53E-6 | YOR382W | FIT2 | hom | Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall |
0.077 | 9.26E-6 | YGR069W_d | YGR069W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.075 | 1.36E-5 | YOL028C | YAP7 | hom | Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication |
0.073 | 2.36E-5 | YLR211C_p | YLR211C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron |
0.073 | 2.67E-5 | YDR055W | PST1 | hom | Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1 |
0.072 | 3.19E-5 | YEL041W | YEF1 | hom | ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication |
0.069 | 6.29E-5 | YDL135C | RDI1 | hom | Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress |