YDL202W / MRPL11

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL202W / MRPL11

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:4.75|P-value:1.47E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.24|P-value:7.28E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:4.29|P-value:1.19E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.46|P-value:3.30E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.64|P-value:1.70E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.68|P-value:1.43E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:13.50|P-value:1.62E-40 ID:SGTC_195|Compound:4234-0266|FD-Score:3.35|P-value:4.87E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:11.90|P-value:3.65E-32 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.56|P-value:1.78E-17 ID:SGTC_310|Compound:1273-0058|FD-Score:6.19|P-value:5.35E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:3.62|P-value:1.83E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.72|P-value:1.25E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.11|P-value:2.47E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.62|P-value:2.75E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:5.28|P-value:1.03E-7 ID:SGTC_579|Compound:4491-1009|FD-Score:6.50|P-value:7.82E-11 ID:SGTC_588|Compound:3970-1144|FD-Score:4.61|P-value:2.78E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:3.26|P-value:6.66E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.33|P-value:5.30E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.33|P-value:5.25E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.50|P-value:2.89E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.53|P-value:2.55E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.28|P-value:6.26E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.44|P-value:3.60E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.66|P-value:1.52E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.32|P-value:1.07E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.17|P-value:8.95E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:4.00|P-value:4.22E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.48|P-value:5.17E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.68|P-value:1.46E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.79|P-value:9.49E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.19|P-value:8.60E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.16|P-value:2.10E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.99|P-value:4.37E-5 ID:SGTC_1591|Compound:genipin|FD-Score:4.06|P-value:3.19E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.31|P-value:5.36E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.45|P-value:3.36E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.22|P-value:7.75E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.03|P-value:3.70E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.21|P-value:7.89E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.45|P-value:3.45E-4 ID:SGTC_2161|Compound:5662504|FD-Score:4.77|P-value:1.32E-6 ID:SGTC_2183|Compound:6420625|FD-Score:3.36|P-value:4.77E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.64|P-value:1.41E-8 ID:SGTC_2308|Compound:7584454|FD-Score:3.23|P-value:7.33E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.58|P-value:2.14E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.57|P-value:2.19E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.33|P-value:5.18E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.43|P-value:6.27E-6 ID:SGTC_2917|Compound:7979103|FD-Score:-3.81|P-value:8.55E-5 ID:SGTC_2971|Compound:9092186|FD-Score:3.77|P-value:1.03E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.24|P-value:7.15E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-4.48|P-value:4.90E-6 ID:SGTC_3194|Compound:9111903|FD-Score:-3.84|P-value:7.50E-5 ID:SGTC_3198|Compound:9112019|FD-Score:3.92|P-value:5.71E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.38|P-value:4.30E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:4.75|P-value:1.47E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.24|P-value:7.28E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:4.29|P-value:1.19E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.46|P-value:3.30E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.64|P-value:1.70E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.68|P-value:1.43E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:13.50|P-value:1.62E-40 ID:SGTC_195|Compound:4234-0266|FD-Score:3.35|P-value:4.87E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:11.90|P-value:3.65E-32 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.56|P-value:1.78E-17 ID:SGTC_310|Compound:1273-0058|FD-Score:6.19|P-value:5.35E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:3.62|P-value:1.83E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.72|P-value:1.25E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.11|P-value:2.47E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.62|P-value:2.75E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:5.28|P-value:1.03E-7 ID:SGTC_579|Compound:4491-1009|FD-Score:6.50|P-value:7.82E-11 ID:SGTC_588|Compound:3970-1144|FD-Score:4.61|P-value:2.78E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:3.26|P-value:6.66E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.33|P-value:5.30E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.33|P-value:5.25E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.50|P-value:2.89E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.53|P-value:2.55E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.28|P-value:6.26E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.44|P-value:3.60E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.66|P-value:1.52E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.32|P-value:1.07E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.17|P-value:8.95E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:4.00|P-value:4.22E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.48|P-value:5.17E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.68|P-value:1.46E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.79|P-value:9.49E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.19|P-value:8.60E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.16|P-value:2.10E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.99|P-value:4.37E-5 ID:SGTC_1591|Compound:genipin|FD-Score:4.06|P-value:3.19E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.31|P-value:5.36E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.45|P-value:3.36E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.22|P-value:7.75E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.03|P-value:3.70E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.21|P-value:7.89E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.45|P-value:3.45E-4 ID:SGTC_2161|Compound:5662504|FD-Score:4.77|P-value:1.32E-6 ID:SGTC_2183|Compound:6420625|FD-Score:3.36|P-value:4.77E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.64|P-value:1.41E-8 ID:SGTC_2308|Compound:7584454|FD-Score:3.23|P-value:7.33E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.58|P-value:2.14E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.57|P-value:2.19E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.33|P-value:5.18E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.43|P-value:6.27E-6 ID:SGTC_2917|Compound:7979103|FD-Score:-3.81|P-value:8.55E-5 ID:SGTC_2971|Compound:9092186|FD-Score:3.77|P-value:1.03E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.24|P-value:7.15E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-4.48|P-value:4.90E-6 ID:SGTC_3194|Compound:9111903|FD-Score:-3.84|P-value:7.50E-5 ID:SGTC_3198|Compound:9112019|FD-Score:3.92|P-value:5.71E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.38|P-value:4.30E-4

Top fitness defect scores for YDL202W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 13.50 2.7 µM 1.62E-40 mitochondrial stress 12 1.08E-41
2 SGTC_236 1509-0011 11.90 5.3 µM 3.65E-32 152 4.33E-33
3 SGTC_275 trichlorophene 8.56 5.7 µM 1.78E-17 mitochondrial stress 63 5.82E-18
4 SGTC_579 4491-1009 6.50 110.0 µM 7.82E-11 60S ribosome export 1 4.04E-11
5 SGTC_310 1273-0058 6.19 1.1 µM 5.35E-10 mitochondrial stress 138 2.93E-10
6 SGTC_2250 alverine citrate 5.64 130.0 µM 1.41E-8 65 8.53E-9
7 SGTC_566 0958-0068 5.28 16.5 µM 1.03E-7 RSC & ERG11 9 6.62E-8
8 SGTC_2161 5662504 4.77 8.5 µM 1.32E-6 tubulin folding & SWR complex 11 9.10E-7
9 SGTC_19 0279-0214 4.75 38.4 µM 1.47E-6 TRP & mitochondrial translation 23 1.02E-6
10 SGTC_503 tyrphostin 8 4.62 294.0 µM 2.75E-6 TSC3-RPN4 13 1.95E-6
11 SGTC_588 3970-1144 4.61 52.9 µM 2.78E-6 17 1.97E-6
12 SGTC_1348 1493-0373 4.48 93.8 µM 5.17E-6 11 3.72E-6
13 SGTC_1318 1280-3875 4.32 124.0 µM 1.07E-5 19 7.85E-6
14 SGTC_50 0929-0078 4.29 56.4 µM 1.19E-5 37 8.82E-6
15 SGTC_1451 4152-0210 4.16 104.0 µM 2.10E-5 19 1.58E-5
16 SGTC_1591 genipin 4.06 88.4 µM 3.19E-5 mitochondrial processes 10 2.42E-5
17 SGTC_1999 st074831 4.03 12.5 µM 3.70E-5 plasma membrane duress 27 2.82E-5
18 SGTC_1328 1441-0025 4.00 69.2 µM 4.22E-5 7 3.23E-5
19 SGTC_1459 k035-0031 3.99 35.7 µM 4.37E-5 DNA intercalators 25 3.35E-5
20 SGTC_3198 9112019 3.92 49.5 µM 5.71E-5 mitochondrial processes 16 4.42E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.473 7.00E-186 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.459 3.38E-174 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.436 7.05E-156 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.434 3.99E-154 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.418 8.85E-142 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.415 1.35E-139 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.407 5.88E-134 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.406 1.27E-133 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.401 3.63E-130 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.400 3.68E-129 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.391 5.46E-123 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.391 1.19E-122 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.389 1.45E-121 YKL016C ATP7 hom Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.387 1.81E-120 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.387 1.88E-120 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit