YDL204W / RTN2

Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL204W / RTN2

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:-3.69|P-value:6.10E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.71|P-value:1.47E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:3.69|P-value:5.21E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.47|P-value:3.64E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.18|P-value:1.04E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.70|P-value:5.09E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.89|P-value:2.76E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.54|P-value:8.17E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.11|P-value:1.34E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.53|P-value:8.56E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.91|P-value:2.61E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.57|P-value:7.55E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-4.36|P-value:6.73E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:4.71|P-value:1.45E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.58|P-value:7.33E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:6.45|P-value:5.53E-9 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.67|P-value:5.51E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.81|P-value:3.55E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.00|P-value:1.93E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.42|P-value:4.32E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:-4.13|P-value:1.49E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-4.17|P-value:1.27E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.68|P-value:5.36E-4 ID:SGTC_1641|Compound:st009299|FD-Score:-3.98|P-value:2.42E-4 ID:SGTC_1731|Compound:st035964|FD-Score:4.47|P-value:3.59E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.48|P-value:9.86E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.95|P-value:2.27E-4 ID:SGTC_2011|Compound:4012611|FD-Score:5.41|P-value:8.16E-7 ID:SGTC_2148|Compound:5546263|FD-Score:3.81|P-value:3.60E-4 ID:SGTC_2210|Compound:7115885|FD-Score:5.25|P-value:1.60E-6 ID:SGTC_2315|Compound:7733312|FD-Score:5.53|P-value:4.69E-7 ID:SGTC_2342|Compound:7990637|FD-Score:-4.12|P-value:1.51E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.55|P-value:8.12E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:7.53|P-value:1.32E-11 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.74|P-value:4.45E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.56|P-value:9.01E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.64|P-value:6.04E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.14|P-value:1.20E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.61|P-value:7.92E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.54|P-value:8.38E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.91|P-value:3.06E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-4.26|P-value:9.58E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.63|P-value:6.21E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.54|P-value:8.33E-4 ID:SGTC_3043|Compound:9092303|FD-Score:4.66|P-value:1.80E-5 ID:SGTC_3097|Compound:9117246|FD-Score:4.65|P-value:1.82E-5 ID:SGTC_3134|Compound:9127454|FD-Score:3.51|P-value:8.98E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-4.24|P-value:1.02E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.40|P-value:4.67E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.80|P-value:3.69E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.69|P-value:6.10E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.71|P-value:1.47E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:3.69|P-value:5.21E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.47|P-value:3.64E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.18|P-value:1.04E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.70|P-value:5.09E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.89|P-value:2.76E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.54|P-value:8.17E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.11|P-value:1.34E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.53|P-value:8.56E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.91|P-value:2.61E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.57|P-value:7.55E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-4.36|P-value:6.73E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:4.71|P-value:1.45E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.58|P-value:7.33E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:6.45|P-value:5.53E-9 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.67|P-value:5.51E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.81|P-value:3.55E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.00|P-value:1.93E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.42|P-value:4.32E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:-4.13|P-value:1.49E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-4.17|P-value:1.27E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.68|P-value:5.36E-4 ID:SGTC_1641|Compound:st009299|FD-Score:-3.98|P-value:2.42E-4 ID:SGTC_1731|Compound:st035964|FD-Score:4.47|P-value:3.59E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.48|P-value:9.86E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.95|P-value:2.27E-4 ID:SGTC_2011|Compound:4012611|FD-Score:5.41|P-value:8.16E-7 ID:SGTC_2148|Compound:5546263|FD-Score:3.81|P-value:3.60E-4 ID:SGTC_2210|Compound:7115885|FD-Score:5.25|P-value:1.60E-6 ID:SGTC_2315|Compound:7733312|FD-Score:5.53|P-value:4.69E-7 ID:SGTC_2342|Compound:7990637|FD-Score:-4.12|P-value:1.51E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.55|P-value:8.12E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:7.53|P-value:1.32E-11 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.74|P-value:4.45E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.56|P-value:9.01E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.64|P-value:6.04E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.14|P-value:1.20E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.61|P-value:7.92E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.54|P-value:8.38E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.91|P-value:3.06E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-4.26|P-value:9.58E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.63|P-value:6.21E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.54|P-value:8.33E-4 ID:SGTC_3043|Compound:9092303|FD-Score:4.66|P-value:1.80E-5 ID:SGTC_3097|Compound:9117246|FD-Score:4.65|P-value:1.82E-5 ID:SGTC_3134|Compound:9127454|FD-Score:3.51|P-value:8.98E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-4.24|P-value:1.02E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.40|P-value:4.67E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.80|P-value:3.69E-4

Top fitness defect scores for YDL204W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2406 ethylparaben 7.53 405.7 µM 1.32E-11 4 2.55E-14
2 SGTC_1206 3978-0017 6.45 132.0 µM 5.53E-9 ERG2 9 5.56E-11
3 SGTC_2315 7733312 5.53 200.0 µM 4.69E-7 7 1.57E-8
4 SGTC_2011 4012611 5.41 177.0 µM 8.16E-7 mitochondrial processes 9 3.18E-8
5 SGTC_2210 7115885 5.25 190.4 µM 1.60E-6 cell wall signaling 15 7.46E-8
6 SGTC_935 2996-0153 4.71 430.0 µM 1.45E-5 PDR1 9 1.22E-6
7 SGTC_88 0180-0332 4.71 8.7 µM 1.47E-5 10 1.24E-6
8 SGTC_3043 9092303 4.66 49.5 µM 1.80E-5 5 1.60E-6
9 SGTC_3097 9117246 4.65 49.5 µM 1.82E-5 4 1.63E-6
10 SGTC_1731 st035964 4.47 63.0 µM 3.59E-5 15 3.84E-6
11 SGTC_212 3807-4682 4.47 38.8 µM 3.64E-5 tubulin folding & SWR complex 47 3.90E-6
12 SGTC_1374 2889-5571 4.42 141.0 µM 4.32E-5 RSC complex & mRNA processing 27 4.84E-6
13 SGTC_3204 9114183 4.40 49.5 µM 4.67E-5 22 5.34E-6
14 SGTC_243 5hr heat shock (37°C) + splitomicin 4.18 1.0 µM 1.04E-4 heat shock/prefoldin 45 1.47E-5
15 SGTC_2565 isoliquiritigenin 4.14 100.0 µM 1.20E-4 32 1.75E-5
16 SGTC_747 3448-8087 4.11 38.7 µM 1.34E-4 21 2.02E-5
17 SGTC_1342 1486-1464 4.00 234.0 µM 1.93E-4 15 3.21E-5
18 SGTC_1964 st076914 3.95 61.0 µM 2.27E-4 RPP1 & pyrimidine depletion 19 3.92E-5
19 SGTC_805 3852-0218 3.91 479.0 µM 2.61E-4 ERAD & cell cycle 72 4.69E-5
20 SGTC_382 3229-0966 3.89 23.2 µM 2.76E-4 23 5.02E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.18E-13 YDL211C_p YDL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.109 2.76E-10 YJR080C AIM24 hom Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss
0.103 1.89E-9 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.084 1.14E-6 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.083 1.53E-6 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.081 2.78E-6 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.080 3.28E-6 YKR055W RHO4 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
0.079 4.30E-6 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.077 8.06E-6 YOR370C MRS6 het Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress
0.076 1.12E-5 YBR224W_d YBR224W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
0.075 1.51E-5 YDR262W_p YDR262W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
0.074 1.58E-5 YHR028C DAP2 hom Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
0.072 2.65E-5 YBL095W_p YBL095W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.072 2.81E-5 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.072 2.95E-5 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation