YDL205C / HEM3

Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL205C / HEM3

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.82|P-value:7.00E-7 ID:SGTC_60|Compound:0986-0278|FD-Score:3.35|P-value:3.49E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.47|P-value:2.58E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.87|P-value:5.47E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:6.50|P-value:2.88E-11 ID:SGTC_168|Compound:3970-0862|FD-Score:3.91|P-value:3.86E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:14.20|P-value:2.34E-46 ID:SGTC_227|Compound:fluconazole|FD-Score:8.93|P-value:1.21E-19 ID:SGTC_266|Compound:formosanin C|FD-Score:5.03|P-value:1.97E-7 ID:SGTC_288|Compound:1315-0019|FD-Score:3.82|P-value:5.67E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.14|P-value:8.61E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-4.49|P-value:3.49E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:5.36|P-value:3.13E-8 ID:SGTC_553|Compound:k007-0256|FD-Score:13.90|P-value:1.10E-44 ID:SGTC_576|Compound:1073-0113|FD-Score:4.07|P-value:1.96E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:11.60|P-value:1.18E-31 ID:SGTC_674|Compound:0498-0004|FD-Score:4.48|P-value:3.05E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:3.58|P-value:1.47E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.25|P-value:5.73E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-4.51|P-value:3.20E-6 ID:SGTC_730|Compound:1436-0052|FD-Score:5.08|P-value:1.50E-7 ID:SGTC_731|Compound:3966-0296|FD-Score:4.03|P-value:2.32E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:3.52|P-value:1.86E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-6.48|P-value:4.10E-11 ID:SGTC_822|Compound:1487-0950|FD-Score:4.23|P-value:9.80E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:-4.01|P-value:3.02E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.10|P-value:9.81E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:13.60|P-value:6.57E-43 ID:SGTC_875|Compound:0709-0210|FD-Score:5.35|P-value:3.37E-8 ID:SGTC_895|Compound:0964-0006|FD-Score:6.32|P-value:9.22E-11 ID:SGTC_902|Compound:1120-0002|FD-Score:9.04|P-value:4.34E-20 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.57|P-value:1.96E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:5.82|P-value:2.13E-9 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.36|P-value:3.46E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:15.50|P-value:1.91E-55 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.26|P-value:5.72E-8 ID:SGTC_1098|Compound:clofazimine|FD-Score:12.00|P-value:4.83E-34 ID:SGTC_1113|Compound:artemisinin|FD-Score:13.60|P-value:5.15E-43 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.05|P-value:2.11E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.91|P-value:3.91E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.13|P-value:7.78E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.15|P-value:7.12E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.11|P-value:9.32E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.20|P-value:1.11E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:-4.72|P-value:1.14E-6 ID:SGTC_1289|Compound:0976-0073|FD-Score:-3.87|P-value:5.33E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:6.28|P-value:1.18E-10 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.44|P-value:2.56E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.70|P-value:9.37E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.72|P-value:8.44E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.81|P-value:2.29E-9 ID:SGTC_1540|Compound:guanosine|FD-Score:8.23|P-value:5.75E-17 ID:SGTC_1547|Compound:harmine|FD-Score:4.22|P-value:9.97E-6 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:11.60|P-value:5.15E-32 ID:SGTC_1556|Compound:plumbagin|FD-Score:20.70|P-value:1.13E-96 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.50|P-value:2.37E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.58|P-value:1.48E-4 ID:SGTC_2001|Compound:4023502|FD-Score:4.92|P-value:3.45E-7 ID:SGTC_2065|Compound:5221596|FD-Score:3.12|P-value:7.87E-4 ID:SGTC_2066|Compound:5222451|FD-Score:15.90|P-value:2.78E-58 ID:SGTC_2124|Compound:5246320|FD-Score:9.76|P-value:4.07E-23 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.74|P-value:7.92E-5 ID:SGTC_2210|Compound:7115885|FD-Score:3.22|P-value:5.72E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.63|P-value:1.47E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:8.34|P-value:2.14E-17 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.78|P-value:8.74E-7 ID:SGTC_2257|Compound:7960413|FD-Score:3.28|P-value:4.52E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.79|P-value:6.69E-7 ID:SGTC_2317|Compound:5986382|FD-Score:-3.74|P-value:9.07E-5 ID:SGTC_2319|Compound:6033012|FD-Score:-3.81|P-value:7.03E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-3.33|P-value:4.39E-4 ID:SGTC_2336|Compound:9001819|FD-Score:16.40|P-value:1.27E-61 ID:SGTC_2344|Compound:7990960|FD-Score:11.50|P-value:3.43E-31 ID:SGTC_2345|Compound:9052315|FD-Score:-3.32|P-value:4.51E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:17.60|P-value:2.76E-70 ID:SGTC_2409|Compound:alverine citrate|FD-Score:6.14|P-value:2.90E-10 ID:SGTC_2415|Compound:st077333|FD-Score:5.29|P-value:4.86E-8 ID:SGTC_2430|Compound:5571206|FD-Score:3.14|P-value:7.48E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:12.00|P-value:8.19E-34 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.80|P-value:6.29E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:10.30|P-value:1.18E-25 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:8.77|P-value:4.96E-19 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.47|P-value:2.30E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.32|P-value:4.51E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.61|P-value:1.33E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:6.46|P-value:3.64E-11 ID:SGTC_2789|Compound:5281112|FD-Score:-3.99|P-value:3.26E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.52|P-value:2.53E-6 ID:SGTC_2928|Compound:9011484|FD-Score:12.00|P-value:4.60E-34 ID:SGTC_2930|Compound:9013230|FD-Score:10.50|P-value:2.55E-26 ID:SGTC_3318|Compound:9139014|FD-Score:3.91|P-value:3.99E-5 ID:SGTC_3341|Compound:9147222|FD-Score:-3.37|P-value:3.83E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.61|P-value:1.32E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.82|P-value:7.00E-7 ID:SGTC_60|Compound:0986-0278|FD-Score:3.35|P-value:3.49E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.47|P-value:2.58E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.87|P-value:5.47E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:6.50|P-value:2.88E-11 ID:SGTC_168|Compound:3970-0862|FD-Score:3.91|P-value:3.86E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:14.20|P-value:2.34E-46 ID:SGTC_227|Compound:fluconazole|FD-Score:8.93|P-value:1.21E-19 ID:SGTC_266|Compound:formosanin C|FD-Score:5.03|P-value:1.97E-7 ID:SGTC_288|Compound:1315-0019|FD-Score:3.82|P-value:5.67E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.14|P-value:8.61E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-4.49|P-value:3.49E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:5.36|P-value:3.13E-8 ID:SGTC_553|Compound:k007-0256|FD-Score:13.90|P-value:1.10E-44 ID:SGTC_576|Compound:1073-0113|FD-Score:4.07|P-value:1.96E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:11.60|P-value:1.18E-31 ID:SGTC_674|Compound:0498-0004|FD-Score:4.48|P-value:3.05E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:3.58|P-value:1.47E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.25|P-value:5.73E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-4.51|P-value:3.20E-6 ID:SGTC_730|Compound:1436-0052|FD-Score:5.08|P-value:1.50E-7 ID:SGTC_731|Compound:3966-0296|FD-Score:4.03|P-value:2.32E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:3.52|P-value:1.86E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-6.48|P-value:4.10E-11 ID:SGTC_822|Compound:1487-0950|FD-Score:4.23|P-value:9.80E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:-4.01|P-value:3.02E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.10|P-value:9.81E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:13.60|P-value:6.57E-43 ID:SGTC_875|Compound:0709-0210|FD-Score:5.35|P-value:3.37E-8 ID:SGTC_895|Compound:0964-0006|FD-Score:6.32|P-value:9.22E-11 ID:SGTC_902|Compound:1120-0002|FD-Score:9.04|P-value:4.34E-20 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.57|P-value:1.96E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:5.82|P-value:2.13E-9 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.36|P-value:3.46E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:15.50|P-value:1.91E-55 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.26|P-value:5.72E-8 ID:SGTC_1098|Compound:clofazimine|FD-Score:12.00|P-value:4.83E-34 ID:SGTC_1113|Compound:artemisinin|FD-Score:13.60|P-value:5.15E-43 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.05|P-value:2.11E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.91|P-value:3.91E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.13|P-value:7.78E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.15|P-value:7.12E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.11|P-value:9.32E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.20|P-value:1.11E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:-4.72|P-value:1.14E-6 ID:SGTC_1289|Compound:0976-0073|FD-Score:-3.87|P-value:5.33E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:6.28|P-value:1.18E-10 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.44|P-value:2.56E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.70|P-value:9.37E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.72|P-value:8.44E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.81|P-value:2.29E-9 ID:SGTC_1540|Compound:guanosine|FD-Score:8.23|P-value:5.75E-17 ID:SGTC_1547|Compound:harmine|FD-Score:4.22|P-value:9.97E-6 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:11.60|P-value:5.15E-32 ID:SGTC_1556|Compound:plumbagin|FD-Score:20.70|P-value:1.13E-96 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.50|P-value:2.37E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.58|P-value:1.48E-4 ID:SGTC_2001|Compound:4023502|FD-Score:4.92|P-value:3.45E-7 ID:SGTC_2065|Compound:5221596|FD-Score:3.12|P-value:7.87E-4 ID:SGTC_2066|Compound:5222451|FD-Score:15.90|P-value:2.78E-58 ID:SGTC_2124|Compound:5246320|FD-Score:9.76|P-value:4.07E-23 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.74|P-value:7.92E-5 ID:SGTC_2210|Compound:7115885|FD-Score:3.22|P-value:5.72E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.63|P-value:1.47E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:8.34|P-value:2.14E-17 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.78|P-value:8.74E-7 ID:SGTC_2257|Compound:7960413|FD-Score:3.28|P-value:4.52E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.79|P-value:6.69E-7 ID:SGTC_2317|Compound:5986382|FD-Score:-3.74|P-value:9.07E-5 ID:SGTC_2319|Compound:6033012|FD-Score:-3.81|P-value:7.03E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-3.33|P-value:4.39E-4 ID:SGTC_2336|Compound:9001819|FD-Score:16.40|P-value:1.27E-61 ID:SGTC_2344|Compound:7990960|FD-Score:11.50|P-value:3.43E-31 ID:SGTC_2345|Compound:9052315|FD-Score:-3.32|P-value:4.51E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:17.60|P-value:2.76E-70 ID:SGTC_2409|Compound:alverine citrate|FD-Score:6.14|P-value:2.90E-10 ID:SGTC_2415|Compound:st077333|FD-Score:5.29|P-value:4.86E-8 ID:SGTC_2430|Compound:5571206|FD-Score:3.14|P-value:7.48E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:12.00|P-value:8.19E-34 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.80|P-value:6.29E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:10.30|P-value:1.18E-25 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:8.77|P-value:4.96E-19 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.47|P-value:2.30E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.32|P-value:4.51E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.61|P-value:1.33E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:6.46|P-value:3.64E-11 ID:SGTC_2789|Compound:5281112|FD-Score:-3.99|P-value:3.26E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.52|P-value:2.53E-6 ID:SGTC_2928|Compound:9011484|FD-Score:12.00|P-value:4.60E-34 ID:SGTC_2930|Compound:9013230|FD-Score:10.50|P-value:2.55E-26 ID:SGTC_3318|Compound:9139014|FD-Score:3.91|P-value:3.99E-5 ID:SGTC_3341|Compound:9147222|FD-Score:-3.37|P-value:3.83E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.61|P-value:1.32E-4

Top fitness defect scores for YDL205C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1556 plumbagin 20.70 1.5 µM 1.13E-96 superoxide 1 1.58E-95 5.31
2 SGTC_2408 sulbentine 17.60 18.4 µM 2.76E-70 1 1.94E-69 6.73
3 SGTC_2336 9001819 16.40 198.7 µM 1.27E-61 heme biosynthesis & mitochondrial translocase 3 7.14E-61 4.29
4 SGTC_2066 5222451 15.90 176.0 µM 2.78E-58 heme biosynthesis & mitochondrial translocase 1 1.43E-57 2.45
5 SGTC_1044 1222-0021 15.50 1.8 µM 1.91E-55 heme biosynthesis & mitochondrial translocase 1 9.12E-55 3.43
6 SGTC_208 k072-0098 14.20 12.4 µM 2.34E-46 heme biosynthesis & mitochondrial translocase 1 8.78E-46 2.20
7 SGTC_553 k007-0256 13.90 45.7 µM 1.10E-44 heme biosynthesis & mitochondrial translocase 1 3.95E-44 2.74
8 SGTC_1113 artemisinin 13.60 1.2 µM 5.15E-43 heme biosynthesis & mitochondrial translocase 3 1.77E-42 4.38
9 SGTC_842 0271-0008 13.60 11.1 µM 6.57E-43 heme biosynthesis & mitochondrial translocase 1 2.25E-42 2.88
10 SGTC_2928 9011484 12.00 9.8 µM 4.60E-34 heme biosynthesis & mitochondrial translocase 1 1.24E-33 3.08
11 SGTC_1098 clofazimine 12.00 15.1 µM 4.83E-34 heme biosynthesis & mitochondrial translocase 2 1.30E-33 0.43
12 SGTC_2519 cryptotanshinone 12.00 88.0 µM 8.19E-34 heme biosynthesis & mitochondrial translocase 3 2.20E-33 1.31
13 SGTC_1552 6-methylflavone 11.60 10.6 µM 5.15E-32 superoxide 1 1.31E-31 2.67
14 SGTC_623 k072-0108 11.60 16.9 µM 1.18E-31 heme biosynthesis & mitochondrial translocase 3 2.98E-31 1.25
15 SGTC_2344 7990960 11.50 77.0 µM 3.43E-31 5 8.58E-31 1.02
16 SGTC_2930 9013230 10.50 14.9 µM 2.55E-26 heme biosynthesis & mitochondrial translocase 4 5.57E-26 0.32
17 SGTC_2575 plumbagin 10.30 510.0 nM 1.18E-25 superoxide 1 2.52E-25 1.47
18 SGTC_2124 5246320 9.76 200.0 µM 4.07E-23 heme biosynthesis & mitochondrial translocase 7 8.14E-23 0.02
19 SGTC_902 1120-0002 9.04 2.1 µM 4.34E-20 azole & statin 2 7.98E-20 2.22
20 SGTC_227 fluconazole 8.93 33.5 µM 1.21E-19 azole & statin 15 2.19E-19 0.23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.477 3.84E-190 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.441 7.54E-160 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.395 2.11E-125 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.357 3.26E-101 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.345 1.07E-94 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.297 1.88E-69 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.294 6.78E-68 YDL147W RPN5 het Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein
0.286 5.06E-64 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.275 4.83E-59 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.272 7.13E-58 YDR427W RPN9 het Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress
0.270 3.92E-57 YKR008W RSC4 het Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
0.263 2.69E-54 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.257 1.03E-51 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.248 2.26E-48 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.245 8.46E-47 YDR303C RSC3 het Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p