YDL207W / GLE1

Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL207W / GLE1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.24|P-value:1.16E-8 ID:SGTC_68|Compound:0986-0284|FD-Score:-5.82|P-value:4.85E-10 ID:SGTC_69|Compound:0096-0274|FD-Score:4.72|P-value:2.42E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-2.97|P-value:9.79E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:2.95|P-value:7.98E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.05|P-value:7.45E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:3.27|P-value:2.30E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.07|P-value:6.84E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:7.78|P-value:6.65E-17 ID:SGTC_341|Compound:1486-1430|FD-Score:3.20|P-value:3.00E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.08|P-value:4.90E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.44|P-value:1.07E-6 ID:SGTC_634|Compound:1611-4317|FD-Score:3.89|P-value:1.61E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.21|P-value:3.53E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:4.26|P-value:2.75E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:4.70|P-value:2.69E-7 ID:SGTC_839|Compound:0122-0028|FD-Score:4.52|P-value:7.11E-7 ID:SGTC_851|Compound:0394-0702|FD-Score:4.00|P-value:9.64E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:3.12|P-value:4.18E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.42|P-value:1.29E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.03|P-value:7.79E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.64|P-value:5.06E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.53|P-value:8.16E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.50|P-value:1.25E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.93|P-value:1.33E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.64|P-value:4.87E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:44.60|P-value:0 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.56|P-value:7.13E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.45|P-value:1.00E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.95|P-value:1.23E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.98|P-value:9.59E-11 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.10|P-value:4.51E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.10|P-value:6.10E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:2.97|P-value:7.29E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.00|P-value:6.53E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.76|P-value:2.90E-5 ID:SGTC_1727|Compound:st034309|FD-Score:3.65|P-value:4.83E-5 ID:SGTC_1729|Compound:st035615|FD-Score:5.34|P-value:6.48E-9 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.43|P-value:1.21E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.35|P-value:2.31E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.63|P-value:5.23E-5 ID:SGTC_1997|Compound:st073024|FD-Score:3.16|P-value:3.52E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.29|P-value:2.16E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.65|P-value:4.73E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.04|P-value:5.70E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.41|P-value:1.33E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.21|P-value:3.96E-4 ID:SGTC_2429|Compound:5902844|FD-Score:5.56|P-value:1.53E-9 ID:SGTC_2967|Compound:9089538|FD-Score:3.13|P-value:4.03E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.06|P-value:7.22E-6 ID:SGTC_3001|Compound:9076041|FD-Score:3.06|P-value:5.23E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.22|P-value:3.80E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-3.40|P-value:1.91E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.24|P-value:1.16E-8 ID:SGTC_68|Compound:0986-0284|FD-Score:-5.82|P-value:4.85E-10 ID:SGTC_69|Compound:0096-0274|FD-Score:4.72|P-value:2.42E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-2.97|P-value:9.79E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:2.95|P-value:7.98E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.05|P-value:7.45E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:3.27|P-value:2.30E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.07|P-value:6.84E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:7.78|P-value:6.65E-17 ID:SGTC_341|Compound:1486-1430|FD-Score:3.20|P-value:3.00E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.08|P-value:4.90E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.44|P-value:1.07E-6 ID:SGTC_634|Compound:1611-4317|FD-Score:3.89|P-value:1.61E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.21|P-value:3.53E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:4.26|P-value:2.75E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:4.70|P-value:2.69E-7 ID:SGTC_839|Compound:0122-0028|FD-Score:4.52|P-value:7.11E-7 ID:SGTC_851|Compound:0394-0702|FD-Score:4.00|P-value:9.64E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:3.12|P-value:4.18E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.42|P-value:1.29E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.03|P-value:7.79E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.64|P-value:5.06E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.53|P-value:8.16E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.50|P-value:1.25E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.93|P-value:1.33E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.64|P-value:4.87E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:44.60|P-value:0 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.56|P-value:7.13E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.45|P-value:1.00E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.95|P-value:1.23E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.98|P-value:9.59E-11 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.10|P-value:4.51E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.10|P-value:6.10E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:2.97|P-value:7.29E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.00|P-value:6.53E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.76|P-value:2.90E-5 ID:SGTC_1727|Compound:st034309|FD-Score:3.65|P-value:4.83E-5 ID:SGTC_1729|Compound:st035615|FD-Score:5.34|P-value:6.48E-9 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.43|P-value:1.21E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.35|P-value:2.31E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.63|P-value:5.23E-5 ID:SGTC_1997|Compound:st073024|FD-Score:3.16|P-value:3.52E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.29|P-value:2.16E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.65|P-value:4.73E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.04|P-value:5.70E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.41|P-value:1.33E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.21|P-value:3.96E-4 ID:SGTC_2429|Compound:5902844|FD-Score:5.56|P-value:1.53E-9 ID:SGTC_2967|Compound:9089538|FD-Score:3.13|P-value:4.03E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.06|P-value:7.22E-6 ID:SGTC_3001|Compound:9076041|FD-Score:3.06|P-value:5.23E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.22|P-value:3.80E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-3.40|P-value:1.91E-4

Top fitness defect scores for YDL207W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1294 1000-1494 44.60 117.0 µM 0 1 0 25.80
2 SGTC_332 4112-0506 7.78 40.9 µM 6.65E-17 3 3.65E-15 0.03
3 SGTC_1493 4348-0038 5.98 111.0 µM 9.59E-11 RSC complex & mRNA processing 18 1.11E-9 0.01
4 SGTC_2429 5902844 5.56 64.4 µM 1.53E-9 4 1.31E-8 0.54
5 SGTC_1729 st035615 5.34 46.0 µM 6.48E-9 4 4.74E-8 0.82
6 SGTC_58 0957-0393 5.24 9.0 µM 1.16E-8 cell wall 35 7.92E-8 0.05
7 SGTC_69 0096-0274 4.72 206.7 µM 2.42E-7 mitochondrial processes 30 1.19E-6 0.02
8 SGTC_829 1635-0120 4.70 117.0 µM 2.69E-7 DNA damage response 38 1.31E-6 0.10
9 SGTC_839 0122-0028 4.52 230.0 µM 7.11E-7 RSC complex & mRNA processing 27 3.10E-6 0.01
10 SGTC_1340 1486-1359 4.45 257.0 µM 1.00E-6 3 4.22E-6 0.27
11 SGTC_546 peri-Naphthalide 4.44 147.0 µM 1.07E-6 DNA damage response 19 4.46E-6 0.07
12 SGTC_745 0469-0705 4.26 296.0 µM 2.75E-6 mitochondrial processes 14 1.04E-5 0.24
13 SGTC_673 1082-0474 4.21 110.0 µM 3.53E-6 RSC complex & mRNA processing 48 1.29E-5 0.03
14 SGTC_268 camptothecin 4.07 39.6 µM 6.84E-6 DNA damage response 42 2.33E-5 0.04
15 SGTC_2973 9094665 4.06 18.0 µM 7.22E-6 NEO1 17 2.44E-5 0.10
16 SGTC_138 0850-0259 4.05 40.9 µM 7.45E-6 cell wall 48 2.51E-5 0.15
17 SGTC_851 0394-0702 4.00 453.0 µM 9.64E-6 mitochondrial processes 22 3.16E-5 0.07
18 SGTC_1371 2421-0008 3.95 32.7 µM 1.23E-5 mitochondrial processes 24 3.91E-5 0.14
19 SGTC_1255 0566-0045 3.93 221.0 µM 1.33E-5 excess fatty acid 15 4.20E-5 0.15
20 SGTC_634 1611-4317 3.89 11.2 µM 1.61E-5 ERG2 11 4.99E-5 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.454 3.43E-170 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.450 9.55E-167 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.402 4.17E-130 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.337 7.26E-90 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.297 2.97E-69 YNL128W TEP1 hom PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1
0.295 2.37E-68 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.282 1.60E-62 YOR066W MSA1 hom Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
0.260 1.05E-52 YIL097W FYV10 hom Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin
0.254 1.05E-50 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.251 2.40E-49 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.237 5.18E-44 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.228 7.07E-41 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.217 6.49E-37 YNL136W EAF7 hom Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A
0.210 1.02E-34 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.186 2.05E-27 YPR197C_d YPR197C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data