YDL208W / NHP2

Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL208W / NHP2

Click on Significant Values for Screen Details ID:SGTC_76|Compound:0433-0009|FD-Score:2.95|P-value:4.54E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.42|P-value:5.34E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:3.07|P-value:2.71E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-2.93|P-value:4.57E-4 ID:SGTC_223|Compound:busulfan|FD-Score:2.82|P-value:7.55E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:-2.87|P-value:5.70E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.77|P-value:1.08E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.18|P-value:1.61E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:2.75|P-value:9.85E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:4.33|P-value:5.29E-7 ID:SGTC_664|Compound:1222-0054|FD-Score:2.90|P-value:5.36E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:2.85|P-value:6.75E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.01|P-value:3.54E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.00|P-value:3.67E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.50|P-value:1.97E-7 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.42|P-value:5.36E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.22|P-value:1.33E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.27|P-value:1.13E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.15|P-value:1.80E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.26|P-value:7.73E-7 ID:SGTC_1200|Compound:1643-0193|FD-Score:-4.01|P-value:2.81E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:-4.34|P-value:4.67E-7 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.78|P-value:8.58E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.23|P-value:1.30E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-2.95|P-value:4.14E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-3.54|P-value:3.02E-5 ID:SGTC_1630|Compound:st005209|FD-Score:-4.16|P-value:1.22E-6 ID:SGTC_1633|Compound:st005664|FD-Score:2.86|P-value:6.38E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-4.04|P-value:2.40E-6 ID:SGTC_1675|Compound:st018485|FD-Score:2.91|P-value:5.35E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.99|P-value:9.13E-9 ID:SGTC_1719|Compound:st032227|FD-Score:-3.71|P-value:1.31E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.94|P-value:4.62E-6 ID:SGTC_1736|Compound:st036774|FD-Score:-3.44|P-value:4.94E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-3.55|P-value:2.94E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-3.13|P-value:1.95E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.32|P-value:9.07E-5 ID:SGTC_1747|Compound:st037496|FD-Score:5.30|P-value:1.12E-9 ID:SGTC_1749|Compound:st037932|FD-Score:3.28|P-value:1.10E-4 ID:SGTC_1887|Compound:st057648|FD-Score:2.79|P-value:8.47E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.21|P-value:1.40E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-2.82|P-value:7.02E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.57|P-value:1.14E-7 ID:SGTC_2087|Compound:5276107|FD-Score:3.02|P-value:3.37E-4 ID:SGTC_2287|Compound:7945887|FD-Score:4.12|P-value:1.74E-6 ID:SGTC_2349|Compound:9023730|FD-Score:3.00|P-value:3.72E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.95|P-value:4.25E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.22|P-value:1.32E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-2.86|P-value:5.99E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.57|P-value:2.92E-5 ID:SGTC_2696|Compound:st077691|FD-Score:-2.79|P-value:7.89E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-5.92|P-value:1.09E-11 ID:SGTC_2830|Compound:7992007|FD-Score:-4.17|P-value:1.18E-6 ID:SGTC_2956|Compound:9076196|FD-Score:-2.81|P-value:7.42E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.52|P-value:3.35E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-3.47|P-value:4.28E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-2.96|P-value:3.93E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.89|P-value:5.35E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.63|P-value:1.98E-5 ID:SGTC_3313|Compound:9133968|FD-Score:-3.38|P-value:6.49E-5 ID:SGTC_3314|Compound:9135860|FD-Score:-2.81|P-value:7.30E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:2.95|P-value:4.54E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.42|P-value:5.34E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:3.07|P-value:2.71E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-2.93|P-value:4.57E-4 ID:SGTC_223|Compound:busulfan|FD-Score:2.82|P-value:7.55E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:-2.87|P-value:5.70E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.77|P-value:1.08E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.18|P-value:1.61E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:2.75|P-value:9.85E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:4.33|P-value:5.29E-7 ID:SGTC_664|Compound:1222-0054|FD-Score:2.90|P-value:5.36E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:2.85|P-value:6.75E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.01|P-value:3.54E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.00|P-value:3.67E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.50|P-value:1.97E-7 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.42|P-value:5.36E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.22|P-value:1.33E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.27|P-value:1.13E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.15|P-value:1.80E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.26|P-value:7.73E-7 ID:SGTC_1200|Compound:1643-0193|FD-Score:-4.01|P-value:2.81E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:-4.34|P-value:4.67E-7 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.78|P-value:8.58E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.23|P-value:1.30E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-2.95|P-value:4.14E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-3.54|P-value:3.02E-5 ID:SGTC_1630|Compound:st005209|FD-Score:-4.16|P-value:1.22E-6 ID:SGTC_1633|Compound:st005664|FD-Score:2.86|P-value:6.38E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-4.04|P-value:2.40E-6 ID:SGTC_1675|Compound:st018485|FD-Score:2.91|P-value:5.35E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.99|P-value:9.13E-9 ID:SGTC_1719|Compound:st032227|FD-Score:-3.71|P-value:1.31E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.94|P-value:4.62E-6 ID:SGTC_1736|Compound:st036774|FD-Score:-3.44|P-value:4.94E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-3.55|P-value:2.94E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-3.13|P-value:1.95E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.32|P-value:9.07E-5 ID:SGTC_1747|Compound:st037496|FD-Score:5.30|P-value:1.12E-9 ID:SGTC_1749|Compound:st037932|FD-Score:3.28|P-value:1.10E-4 ID:SGTC_1887|Compound:st057648|FD-Score:2.79|P-value:8.47E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.21|P-value:1.40E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-2.82|P-value:7.02E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.57|P-value:1.14E-7 ID:SGTC_2087|Compound:5276107|FD-Score:3.02|P-value:3.37E-4 ID:SGTC_2287|Compound:7945887|FD-Score:4.12|P-value:1.74E-6 ID:SGTC_2349|Compound:9023730|FD-Score:3.00|P-value:3.72E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.95|P-value:4.25E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.22|P-value:1.32E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-2.86|P-value:5.99E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.57|P-value:2.92E-5 ID:SGTC_2696|Compound:st077691|FD-Score:-2.79|P-value:7.89E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-5.92|P-value:1.09E-11 ID:SGTC_2830|Compound:7992007|FD-Score:-4.17|P-value:1.18E-6 ID:SGTC_2956|Compound:9076196|FD-Score:-2.81|P-value:7.42E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.52|P-value:3.35E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-3.47|P-value:4.28E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-2.96|P-value:3.93E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.89|P-value:5.35E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.63|P-value:1.98E-5 ID:SGTC_3313|Compound:9133968|FD-Score:-3.38|P-value:6.49E-5 ID:SGTC_3314|Compound:9135860|FD-Score:-2.81|P-value:7.30E-4

Top fitness defect scores for YDL208W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1747 st037496 5.30 66.6 µM 1.12E-9 3 5.70E-8 0.65
2 SGTC_1683 st010134 4.99 710.0 nM 9.13E-9 2 2.99E-7 0.74
3 SGTC_879 0831-1030 4.50 162.0 µM 1.97E-7 15 3.40E-6 4.02E-4
4 SGTC_647 0140-0236 4.33 81.0 µM 5.29E-7 5 7.44E-6 0.75
5 SGTC_1193 1488-0126 4.26 41.5 µM 7.73E-7 3 1.01E-5 0.47
6 SGTC_2287 7945887 4.12 168.8 µM 1.74E-6 1 1.91E-5 0.39
7 SGTC_1728 st035614 3.94 33.8 µM 4.62E-6 6 4.16E-5 0.02
8 SGTC_524 r073-0010 3.77 27.8 µM 1.08E-5 15 8.19E-5 0.05
9 SGTC_2689 tacrolimus 3.57 100.0 µM 2.92E-5 17 1.80E-4 0.01
10 SGTC_1744 st037937 3.32 38.9 µM 9.07E-5 10 4.45E-4 0.15
11 SGTC_1749 st037932 3.28 54.2 µM 1.10E-4 18 5.17E-4 0.03
12 SGTC_1180 1193-0155 3.27 285.0 µM 1.13E-4 6 5.29E-4 0.21
13 SGTC_181 1447-1644 3.07 8.1 µM 2.71E-4 endomembrane recycling 25 0.00106 0.10
14 SGTC_2087 5276107 3.02 200.0 µM 3.37E-4 14 0.00127 0.08
15 SGTC_736 0958-0254 3.01 92.6 µM 3.54E-4 Golgi 13 0.00132 0.04
16 SGTC_835 0312-0010 3.00 67.2 µM 3.67E-4 8 0.00136 0.03
17 SGTC_2349 9023730 3.00 187.1 µM 3.72E-4 10 0.00137 0.06
18 SGTC_76 0433-0009 2.95 400.3 µM 4.54E-4 14 0.00161 0.09
19 SGTC_1675 st018485 2.91 24.5 µM 5.35E-4 60S ribosome export 25 0.00183 0.03
20 SGTC_664 1222-0054 2.90 14.9 µM 5.36E-4 sphingolipid biosynthesis & PDR1 20 0.00184 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 5.53E-13 YDL220C CDC13 het Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation
0.118 5.93E-12 YML054C CYB2 hom Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
0.113 6.29E-11 YDL212W SHR3 het Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
0.107 4.28E-10 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.106 7.09E-10 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.100 6.33E-9 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.098 1.48E-8 YNL313C EMW1 het Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
0.093 6.90E-8 YOL136C PFK27 hom 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
0.091 1.14E-7 YBL023C MCM2 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress
0.080 3.07E-6 YNL154C YCK2 hom Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication
0.080 3.94E-6 YOL147C PEX11 hom Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
0.079 4.67E-6 YHR016C YSC84 hom Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication
0.077 8.59E-6 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.076 9.15E-6 YGL229C SAP4 hom Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
0.075 1.22E-5 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress