YDL211C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL211C / YDL211C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.61|P-value:1.48E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.20|P-value:6.55E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.51|P-value:2.19E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.43|P-value:4.49E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:3.10|P-value:9.38E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.10|P-value:9.52E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.17|P-value:1.46E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:3.90|P-value:4.59E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.73|P-value:9.08E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:4.31|P-value:7.90E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.71|P-value:9.85E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:3.52|P-value:2.09E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:5.67|P-value:6.52E-9 ID:SGTC_727|Compound:3032-0951|FD-Score:3.09|P-value:9.78E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.62|P-value:1.40E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.79|P-value:7.11E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.40|P-value:3.31E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.04|P-value:2.60E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.53|P-value:2.84E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-4.46|P-value:3.96E-6 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.54|P-value:2.68E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.72|P-value:9.72E-5 ID:SGTC_1623|Compound:st003709|FD-Score:-6.34|P-value:1.07E-10 ID:SGTC_1910|Compound:st062352|FD-Score:-4.29|P-value:8.71E-6 ID:SGTC_2033|Compound:5192550|FD-Score:-3.68|P-value:1.15E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.35|P-value:3.92E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.81|P-value:6.61E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.27|P-value:5.23E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.08|P-value:2.10E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.14|P-value:1.70E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:4.59|P-value:2.09E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.93|P-value:4.00E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.96|P-value:3.58E-5 ID:SGTC_2917|Compound:7979103|FD-Score:-3.45|P-value:2.74E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.50|P-value:2.26E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.23|P-value:6.09E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.39|P-value:3.36E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.50|P-value:2.23E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.11|P-value:9.13E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-6.46|P-value:4.89E-11 ID:SGTC_3306|Compound:9127676|FD-Score:-3.26|P-value:5.43E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.61|P-value:1.48E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.20|P-value:6.55E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.51|P-value:2.19E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.43|P-value:4.49E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:3.10|P-value:9.38E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.10|P-value:9.52E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.17|P-value:1.46E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:3.90|P-value:4.59E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.73|P-value:9.08E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:4.31|P-value:7.90E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.71|P-value:9.85E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:3.52|P-value:2.09E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:5.67|P-value:6.52E-9 ID:SGTC_727|Compound:3032-0951|FD-Score:3.09|P-value:9.78E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.62|P-value:1.40E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.79|P-value:7.11E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.40|P-value:3.31E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.04|P-value:2.60E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.53|P-value:2.84E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-4.46|P-value:3.96E-6 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.54|P-value:2.68E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.72|P-value:9.72E-5 ID:SGTC_1623|Compound:st003709|FD-Score:-6.34|P-value:1.07E-10 ID:SGTC_1910|Compound:st062352|FD-Score:-4.29|P-value:8.71E-6 ID:SGTC_2033|Compound:5192550|FD-Score:-3.68|P-value:1.15E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.35|P-value:3.92E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.81|P-value:6.61E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.27|P-value:5.23E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.08|P-value:2.10E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.14|P-value:1.70E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:4.59|P-value:2.09E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.93|P-value:4.00E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.96|P-value:3.58E-5 ID:SGTC_2917|Compound:7979103|FD-Score:-3.45|P-value:2.74E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.50|P-value:2.26E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.23|P-value:6.09E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.39|P-value:3.36E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.50|P-value:2.23E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.11|P-value:9.13E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-6.46|P-value:4.89E-11 ID:SGTC_3306|Compound:9127676|FD-Score:-3.26|P-value:5.43E-4

Top fitness defect scores for YDL211C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_695 3505-6186 5.67 243.0 µM 6.52E-9 5 7.10E-9
2 SGTC_2730 imipramine 4.59 71.3 µM 2.09E-6 7 2.22E-6
3 SGTC_1441 4106-0040 4.54 13.0 µM 2.68E-6 6 2.83E-6
4 SGTC_155 k072-0202 4.31 43.6 µM 7.90E-6 12 8.32E-6
5 SGTC_88 0180-0332 4.17 8.7 µM 1.46E-5 19 1.54E-5
6 SGTC_2410 aloe-emodin-8-o-glycoside 4.08 46.3 µM 2.10E-5 mitochondrial processes 25 2.20E-5
7 SGTC_1254 0550-0035 4.04 264.0 µM 2.60E-5 18 2.72E-5
8 SGTC_2777 climbazole 3.96 1.5 µM 3.58E-5 iron homeostasis 52 3.75E-5
9 SGTC_2768 sulfasalazine 3.93 50.2 µM 4.00E-5 13 4.19E-5
10 SGTC_96 0929-0093 3.90 37.3 µM 4.59E-5 calcium & mitochondrial duress 11 4.80E-5
11 SGTC_2144 5628481 3.81 200.0 µM 6.61E-5 ERG2 25 6.90E-5
12 SGTC_1101 ebselen 3.79 5.3 µM 7.11E-5 27 7.42E-5
13 SGTC_143 4032-1194 3.73 15.7 µM 9.08E-5 77 9.46E-5
14 SGTC_1525 8-methoxypsoralen 3.72 92.5 µM 9.72E-5 DNA damage response 39 1.01E-4
15 SGTC_524 r073-0010 3.71 27.8 µM 9.85E-5 60 1.03E-4
16 SGTC_885 0865-0106 3.62 16.8 µM 1.40E-4 TSC3-RPN4 33 1.45E-4
17 SGTC_8 0354-0001 3.61 70.0 µM 1.48E-4 94 1.54E-4
18 SGTC_653 0203-0016 3.52 55.2 µM 2.09E-4 32 2.17E-4
19 SGTC_3217 9129673 3.50 49.5 µM 2.23E-4 59 2.31E-4
20 SGTC_2970 9090938 3.39 41.9 µM 3.36E-4 RNA processing & uracil transport 71 3.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.18E-13 YDL204W RTN2 hom Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication
0.121 2.33E-12 YHR185C PFS1 hom Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation
0.110 1.57E-10 YDR480W DIG2 hom MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
0.102 3.83E-9 YNL020C ARK1 hom Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication
0.093 6.97E-8 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.092 8.77E-8 YDR156W RPA14 hom RNA polymerase I subunit A14
0.092 1.11E-7 YMR302C YME2 hom Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
0.091 1.50E-7 YDR218C SPR28 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
0.090 1.73E-7 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.086 7.18E-7 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.083 1.71E-6 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.081 2.55E-6 YOR046C DBP5 het Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p
0.081 2.56E-6 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.081 3.06E-6 YDR066C RTR2 hom Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication
0.080 3.24E-6 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport