YDL212W / SHR3

Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL212W / SHR3

Click on Significant Values for Screen Details ID:SGTC_361|Compound:000s-0510|FD-Score:5.51|P-value:1.51E-8 ID:SGTC_427|Compound:1354-0053|FD-Score:3.40|P-value:3.35E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.74|P-value:8.93E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.06|P-value:9.30E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:5.36|P-value:3.69E-8 ID:SGTC_991|Compound:3996-0057|FD-Score:-6.13|P-value:2.62E-10 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.81|P-value:6.68E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.86|P-value:4.45E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.87|P-value:4.22E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.60|P-value:1.53E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-5.07|P-value:1.33E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.36|P-value:3.12E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.67|P-value:6.25E-9 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.67|P-value:9.43E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.02|P-value:2.79E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.13|P-value:8.66E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.43|P-value:2.98E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.72|P-value:9.62E-5 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.52|P-value:2.07E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.37|P-value:3.73E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.07|P-value:2.22E-5 ID:SGTC_1608|Compound:st001473|FD-Score:3.58|P-value:1.66E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-3.63|P-value:1.12E-4 ID:SGTC_1667|Compound:st014849|FD-Score:4.41|P-value:4.86E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.26|P-value:5.45E-4 ID:SGTC_1683|Compound:st010134|FD-Score:5.17|P-value:1.03E-7 ID:SGTC_1712|Compound:st032288|FD-Score:4.01|P-value:2.89E-5 ID:SGTC_1716|Compound:st033144|FD-Score:6.47|P-value:3.82E-11 ID:SGTC_1733|Compound:st037357|FD-Score:3.91|P-value:4.47E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.12|P-value:8.90E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.43|P-value:2.45E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.36|P-value:3.17E-4 ID:SGTC_2414|Compound:st077232|FD-Score:5.13|P-value:1.25E-7 ID:SGTC_2439|Compound:5492030|FD-Score:-3.50|P-value:1.85E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.69|P-value:1.07E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.60|P-value:1.57E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.41|P-value:2.65E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.33|P-value:4.22E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-4.27|P-value:7.34E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-3.80|P-value:5.70E-5 ID:SGTC_2833|Compound:9001315|FD-Score:8.31|P-value:3.08E-17 ID:SGTC_2886|Compound:9058944|FD-Score:-3.58|P-value:1.35E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.45|P-value:2.77E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.17|P-value:7.65E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.65|P-value:1.03E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.72|P-value:9.58E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.24|P-value:5.87E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:5.51|P-value:1.51E-8 ID:SGTC_427|Compound:1354-0053|FD-Score:3.40|P-value:3.35E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.74|P-value:8.93E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.06|P-value:9.30E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:5.36|P-value:3.69E-8 ID:SGTC_991|Compound:3996-0057|FD-Score:-6.13|P-value:2.62E-10 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.81|P-value:6.68E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.86|P-value:4.45E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.87|P-value:4.22E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.60|P-value:1.53E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-5.07|P-value:1.33E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.36|P-value:3.12E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.67|P-value:6.25E-9 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.67|P-value:9.43E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.02|P-value:2.79E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.13|P-value:8.66E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.43|P-value:2.98E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.72|P-value:9.62E-5 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.52|P-value:2.07E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.37|P-value:3.73E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.07|P-value:2.22E-5 ID:SGTC_1608|Compound:st001473|FD-Score:3.58|P-value:1.66E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-3.63|P-value:1.12E-4 ID:SGTC_1667|Compound:st014849|FD-Score:4.41|P-value:4.86E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.26|P-value:5.45E-4 ID:SGTC_1683|Compound:st010134|FD-Score:5.17|P-value:1.03E-7 ID:SGTC_1712|Compound:st032288|FD-Score:4.01|P-value:2.89E-5 ID:SGTC_1716|Compound:st033144|FD-Score:6.47|P-value:3.82E-11 ID:SGTC_1733|Compound:st037357|FD-Score:3.91|P-value:4.47E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.12|P-value:8.90E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.43|P-value:2.45E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.36|P-value:3.17E-4 ID:SGTC_2414|Compound:st077232|FD-Score:5.13|P-value:1.25E-7 ID:SGTC_2439|Compound:5492030|FD-Score:-3.50|P-value:1.85E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.69|P-value:1.07E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.60|P-value:1.57E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.41|P-value:2.65E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.33|P-value:4.22E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-4.27|P-value:7.34E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-3.80|P-value:5.70E-5 ID:SGTC_2833|Compound:9001315|FD-Score:8.31|P-value:3.08E-17 ID:SGTC_2886|Compound:9058944|FD-Score:-3.58|P-value:1.35E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.45|P-value:2.77E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.17|P-value:7.65E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.65|P-value:1.03E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.72|P-value:9.58E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.24|P-value:5.87E-4

Top fitness defect scores for YDL212W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2833 9001315 8.31 45.5 µM 3.08E-17 amide catabolism 1 4.77E-17 1.73
2 SGTC_1716 st033144 6.47 30.6 µM 3.82E-11 1 4.80E-11 0.72
3 SGTC_1129 3453-1384 5.67 223.0 µM 6.25E-9 6 7.32E-9 0.28
4 SGTC_361 000s-0510 5.51 1.4 µM 1.51E-8 3 1.75E-8 0.55
5 SGTC_551 k048-0028 5.36 34.9 µM 3.69E-8 2 4.22E-8 0.45
6 SGTC_1683 st010134 5.17 710.0 nM 1.03E-7 1 1.16E-7 0.74
7 SGTC_2414 st077232 5.13 92.9 µM 1.25E-7 2 1.41E-7 0.14
8 SGTC_1667 st014849 4.41 34.6 µM 4.86E-6 Golgi 3 5.21E-6 0.87
9 SGTC_1592 4',5'-dihydroxyflavone 4.07 8.8 µM 2.22E-5 60S ribosome export 5 2.34E-5 0.08
10 SGTC_1134 3477-0009 4.02 42.5 µM 2.79E-5 11 2.93E-5 0.07
11 SGTC_1712 st032288 4.01 53.4 µM 2.89E-5 calcium & mitochondrial duress 36 3.03E-5 0.11
12 SGTC_1733 st037357 3.91 54.9 µM 4.47E-5 60S ribosome export 8 4.66E-5 0.12
13 SGTC_1010 4112-3296 3.81 15.2 µM 6.68E-5 7 6.95E-5 0.26
14 SGTC_480 am 92016 3.74 50.0 µM 8.93E-5 9 9.25E-5 0.05
15 SGTC_3296 9122258 3.72 64.0 µM 9.58E-5 redox potentiating 8 9.91E-5 0.17
16 SGTC_1406 3909-7906 3.72 11.9 µM 9.62E-5 60S ribosome export 7 9.96E-5 0.04
17 SGTC_2464 5717415 3.69 7.7 µM 1.07E-4 3 1.11E-4 0.25
18 SGTC_1019 4262-0212 3.60 3.4 µM 1.53E-4 ergosterol depletion effects on membrane 17 1.57E-4 0.14
19 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.60 3.7 µM 1.57E-4 17 1.61E-4 0.14
20 SGTC_1608 st001473 3.58 40.5 µM 1.66E-4 8 1.71E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.63E-18 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.138 1.07E-15 YDL012C YDL012C hom Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication
0.129 6.85E-14 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.113 6.29E-11 YDL208W NHP2 het Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
0.102 3.55E-9 YLR278C_p YLR278C_p hom Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene
0.101 5.29E-9 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.100 6.34E-9 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.100 7.49E-9 YDR434W GPI17 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog
0.099 8.16E-9 YIL118W RHO3 het Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
0.097 1.78E-8 YLR314C CDC3 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.096 2.78E-8 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.096 2.92E-8 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.094 4.69E-8 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.091 1.18E-7 YLR098C CHA4 hom DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
0.091 1.48E-7 YGR244C LSC2 hom Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate