YDL218W_p

Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL218W / YDL218W

Click on Significant Values for Screen Details ID:SGTC_157|Compound:1348-1695|FD-Score:-3.04|P-value:2.51E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.36|P-value:5.72E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.73|P-value:9.04E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.05|P-value:2.37E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:5.67|P-value:1.72E-11 ID:SGTC_499|Compound:genistein|FD-Score:-3.13|P-value:1.67E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:4.39|P-value:1.36E-7 ID:SGTC_542|Compound:3381-0244|FD-Score:3.82|P-value:3.84E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:2.65|P-value:9.21E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.40|P-value:4.67E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:3.21|P-value:8.23E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:-3.12|P-value:1.75E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.46|P-value:3.56E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:-4.24|P-value:5.44E-7 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.26|P-value:9.01E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:4.14|P-value:6.38E-7 ID:SGTC_843|Compound:0310-0051|FD-Score:3.21|P-value:8.29E-5 ID:SGTC_844|Compound:0330-0132|FD-Score:3.77|P-value:4.95E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:2.74|P-value:6.27E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:-2.89|P-value:4.70E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:-2.71|P-value:9.66E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.25|P-value:9.73E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.75|P-value:8.00E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.42|P-value:4.39E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:3.65|P-value:9.23E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.73|P-value:8.99E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:6.29|P-value:1.07E-13 ID:SGTC_1130|Compound:3454-2858|FD-Score:-5.23|P-value:8.37E-10 ID:SGTC_1134|Compound:3477-0009|FD-Score:7.95|P-value:9.10E-21 ID:SGTC_1195|Compound:1502-0147|FD-Score:-2.93|P-value:3.89E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.34|P-value:6.39E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:2.84|P-value:4.20E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.31|P-value:5.04E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.43|P-value:1.08E-7 ID:SGTC_1248|Compound:0469-0687|FD-Score:-2.93|P-value:3.98E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.21|P-value:1.16E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.60|P-value:1.78E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.76|P-value:7.75E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-2.80|P-value:6.59E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-2.96|P-value:3.47E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:2.63|P-value:9.88E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.65|P-value:1.37E-5 ID:SGTC_2319|Compound:6033012|FD-Score:-2.82|P-value:6.15E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.07|P-value:1.55E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.19|P-value:1.26E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.51|P-value:2.82E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-2.73|P-value:8.75E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.42|P-value:2.95E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.06|P-value:1.65E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.67|P-value:1.25E-5 ID:SGTC_2999|Compound:9069765|FD-Score:2.71|P-value:7.03E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.02|P-value:1.95E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.32|P-value:6.85E-5 ID:SGTC_3171|Compound:9103192|FD-Score:-3.55|P-value:2.24E-5 ID:SGTC_3174|Compound:9107204|FD-Score:2.91|P-value:3.15E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.37|P-value:3.91E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-4.08|P-value:1.35E-6 ID:SGTC_3209|Compound:9113616|FD-Score:4.59|P-value:3.84E-8 ID:SGTC_3212|Compound:9128307|FD-Score:-5.30|P-value:5.17E-10 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.04|P-value:2.51E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.36|P-value:5.72E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.73|P-value:9.04E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.05|P-value:2.37E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:5.67|P-value:1.72E-11 ID:SGTC_499|Compound:genistein|FD-Score:-3.13|P-value:1.67E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:4.39|P-value:1.36E-7 ID:SGTC_542|Compound:3381-0244|FD-Score:3.82|P-value:3.84E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:2.65|P-value:9.21E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.40|P-value:4.67E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:3.21|P-value:8.23E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:-3.12|P-value:1.75E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.46|P-value:3.56E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:-4.24|P-value:5.44E-7 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.26|P-value:9.01E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:4.14|P-value:6.38E-7 ID:SGTC_843|Compound:0310-0051|FD-Score:3.21|P-value:8.29E-5 ID:SGTC_844|Compound:0330-0132|FD-Score:3.77|P-value:4.95E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:2.74|P-value:6.27E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:-2.89|P-value:4.70E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:-2.71|P-value:9.66E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.25|P-value:9.73E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.75|P-value:8.00E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.42|P-value:4.39E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:3.65|P-value:9.23E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.73|P-value:8.99E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:6.29|P-value:1.07E-13 ID:SGTC_1130|Compound:3454-2858|FD-Score:-5.23|P-value:8.37E-10 ID:SGTC_1134|Compound:3477-0009|FD-Score:7.95|P-value:9.10E-21 ID:SGTC_1195|Compound:1502-0147|FD-Score:-2.93|P-value:3.89E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.34|P-value:6.39E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:2.84|P-value:4.20E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.31|P-value:5.04E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.43|P-value:1.08E-7 ID:SGTC_1248|Compound:0469-0687|FD-Score:-2.93|P-value:3.98E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.21|P-value:1.16E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.60|P-value:1.78E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.76|P-value:7.75E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-2.80|P-value:6.59E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-2.96|P-value:3.47E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:2.63|P-value:9.88E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.65|P-value:1.37E-5 ID:SGTC_2319|Compound:6033012|FD-Score:-2.82|P-value:6.15E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.07|P-value:1.55E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.19|P-value:1.26E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.51|P-value:2.82E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-2.73|P-value:8.75E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.42|P-value:2.95E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.06|P-value:1.65E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.67|P-value:1.25E-5 ID:SGTC_2999|Compound:9069765|FD-Score:2.71|P-value:7.03E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.02|P-value:1.95E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.32|P-value:6.85E-5 ID:SGTC_3171|Compound:9103192|FD-Score:-3.55|P-value:2.24E-5 ID:SGTC_3174|Compound:9107204|FD-Score:2.91|P-value:3.15E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.37|P-value:3.91E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-4.08|P-value:1.35E-6 ID:SGTC_3209|Compound:9113616|FD-Score:4.59|P-value:3.84E-8 ID:SGTC_3212|Compound:9128307|FD-Score:-5.30|P-value:5.17E-10

Top fitness defect scores for YDL218W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1134 3477-0009 7.95 42.5 µM 9.10E-21 3 9.20E-16
2 SGTC_1128 3448-9350 6.29 235.0 µM 1.07E-13 3 1.62E-10
3 SGTC_245 methotrexate 5.67 289.6 µM 1.72E-11 15 7.06E-9
4 SGTC_3209 9113616 4.59 49.5 µM 3.84E-8 13 2.18E-6
5 SGTC_1230 0170-0365 4.43 3.8 µM 1.08E-7 endomembrane recycling 48 4.71E-6
6 SGTC_529 4076-0302 4.39 30.3 µM 1.36E-7 mitochondrial processes 11 5.60E-6
7 SGTC_811 0416-0114 4.14 265.0 µM 6.38E-7 14 1.77E-5
8 SGTC_542 3381-0244 3.82 89.3 µM 3.84E-6 42 6.75E-5
9 SGTC_844 0330-0132 3.77 15.3 µM 4.95E-6 18 8.15E-5
10 SGTC_935 2996-0153 3.65 430.0 µM 9.23E-6 PDR1 27 1.30E-4
11 SGTC_2918 7977171 3.42 22.1 µM 2.95E-5 43 3.09E-4
12 SGTC_3202 9113761 3.37 49.5 µM 3.91E-5 73 3.81E-4
13 SGTC_1210 3013-0140 3.31 750.0 nM 5.04E-5 20 4.61E-4
14 SGTC_797 k781-0471 3.21 270.0 µM 8.23E-5 RPP1 & pyrimidine depletion 48 6.65E-4
15 SGTC_843 0310-0051 3.21 143.0 µM 8.29E-5 38 6.69E-4
16 SGTC_2352 9027995 3.07 87.8 µM 1.55E-4 tubulin folding & SWR complex 58 0.00107
17 SGTC_2928 9011484 3.06 9.8 µM 1.65E-4 heme biosynthesis & mitochondrial translocase 67 0.00112
18 SGTC_3081 9117243 3.02 49.5 µM 1.95E-4 fatty acid desaturase (OLE1) 51 0.00127
19 SGTC_3174 9107204 2.91 49.5 µM 3.15E-4 ERG2 85 0.00182
20 SGTC_1209 2323-2347 2.84 50.3 µM 4.20E-4 48 0.00226

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 1.60E-24 YML023C NSE5 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.144 5.73E-17 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.144 6.44E-17 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.142 1.73E-16 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.134 5.51E-15 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.119 4.59E-12 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.115 2.93E-11 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.114 3.06E-11 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.110 1.56E-10 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.109 2.40E-10 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.107 4.62E-10 YPL263C KEL3 hom Cytoplasmic protein of unknown function
0.107 4.84E-10 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.105 1.01E-9 YER027C GAL83 hom One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain
0.103 2.22E-9 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.102 3.39E-9 YIL132C CSM2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis