YDL219W / DTD1

D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL219W / DTD1

Click on Significant Values for Screen Details ID:SGTC_271|Compound:rotenone|FD-Score:3.64|P-value:6.95E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:3.11|P-value:5.45E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.07|P-value:6.39E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:2.95|P-value:9.62E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-5.51|P-value:8.14E-9 ID:SGTC_687|Compound:k029-0044|FD-Score:2.99|P-value:8.33E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.65|P-value:6.60E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:-3.07|P-value:8.89E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.06|P-value:6.55E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.53|P-value:1.07E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.48|P-value:1.89E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.52|P-value:1.64E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.50|P-value:1.78E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.22|P-value:3.61E-4 ID:SGTC_2341|Compound:7987486|FD-Score:5.66|P-value:1.85E-9 ID:SGTC_2346|Compound:9031566|FD-Score:3.12|P-value:5.25E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.15|P-value:6.66E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-3.53|P-value:1.61E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.51|P-value:1.70E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.77|P-value:4.02E-5 ID:SGTC_2478|Compound:5763493|FD-Score:-4.72|P-value:6.91E-7 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.07|P-value:8.70E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.46|P-value:1.62E-6 ID:SGTC_2643|Compound:anethole|FD-Score:-3.31|P-value:3.68E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.23|P-value:3.55E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:-3.22|P-value:5.21E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.38|P-value:2.00E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.42|P-value:1.72E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.25|P-value:4.61E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.41|P-value:2.55E-4 ID:SGTC_2915|Compound:7971052|FD-Score:3.94|P-value:1.89E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.55|P-value:1.01E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.34|P-value:3.31E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.07|P-value:8.72E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.74|P-value:4.54E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.94|P-value:1.88E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-3.06|P-value:9.20E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-5.17|P-value:5.93E-8 ID:SGTC_3134|Compound:9127454|FD-Score:-3.33|P-value:3.46E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.29|P-value:2.83E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.35|P-value:2.21E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.64|P-value:6.95E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:3.11|P-value:5.45E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.07|P-value:6.39E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:2.95|P-value:9.62E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-5.51|P-value:8.14E-9 ID:SGTC_687|Compound:k029-0044|FD-Score:2.99|P-value:8.33E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.65|P-value:6.60E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:-3.07|P-value:8.89E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.06|P-value:6.55E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.53|P-value:1.07E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.48|P-value:1.89E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.52|P-value:1.64E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.50|P-value:1.78E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.22|P-value:3.61E-4 ID:SGTC_2341|Compound:7987486|FD-Score:5.66|P-value:1.85E-9 ID:SGTC_2346|Compound:9031566|FD-Score:3.12|P-value:5.25E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.15|P-value:6.66E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-3.53|P-value:1.61E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.51|P-value:1.70E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.77|P-value:4.02E-5 ID:SGTC_2478|Compound:5763493|FD-Score:-4.72|P-value:6.91E-7 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.07|P-value:8.70E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.46|P-value:1.62E-6 ID:SGTC_2643|Compound:anethole|FD-Score:-3.31|P-value:3.68E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.23|P-value:3.55E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:-3.22|P-value:5.21E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.38|P-value:2.00E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.42|P-value:1.72E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.25|P-value:4.61E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.41|P-value:2.55E-4 ID:SGTC_2915|Compound:7971052|FD-Score:3.94|P-value:1.89E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.55|P-value:1.01E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.34|P-value:3.31E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.07|P-value:8.72E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.74|P-value:4.54E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.94|P-value:1.88E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-3.06|P-value:9.20E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-5.17|P-value:5.93E-8 ID:SGTC_3134|Compound:9127454|FD-Score:-3.33|P-value:3.46E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.29|P-value:2.83E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.35|P-value:2.21E-4

Top fitness defect scores for YDL219W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2341 7987486 5.66 176.7 µM 1.85E-9 4 7.69E-9
2 SGTC_2636 apigenin dimethyl ether 4.46 100.0 µM 1.62E-6 29 4.17E-6
3 SGTC_3075 9116269 3.94 49.5 µM 1.88E-5 21 4.07E-5
4 SGTC_2915 7971052 3.94 15.2 µM 1.89E-5 8 4.08E-5
5 SGTC_2432 5630864 3.77 12.2 µM 4.02E-5 25 8.23E-5
6 SGTC_3001 9076041 3.74 71.4 µM 4.54E-5 18 9.23E-5
7 SGTC_899 1083-0020 3.65 478.0 µM 6.60E-5 30 1.31E-4
8 SGTC_271 rotenone 3.64 740.0 µM 6.95E-5 37 1.37E-4
9 SGTC_2916 7875993 3.55 68.8 µM 1.01E-4 42 1.94E-4
10 SGTC_1399 3562-5772 3.53 25.0 µM 1.07E-4 RPP1 & pyrimidine depletion 25 2.04E-4
11 SGTC_2794 7785382 3.42 27.3 µM 1.72E-4 55 3.18E-4
12 SGTC_2676 harmalol 3.38 100.0 µM 2.00E-4 mitochondrial processes 28 3.66E-4
13 SGTC_3189 9110682 3.35 49.5 µM 2.21E-4 54 4.00E-4
14 SGTC_3142 9086498 3.29 49.5 µM 2.83E-4 iron homeostasis 61 5.04E-4
15 SGTC_2649 anisomycin 3.23 9.6 µM 3.55E-4 23 6.23E-4
16 SGTC_2035 5154463 3.22 94.6 µM 3.61E-4 39 6.32E-4
17 SGTC_2346 9031566 3.12 143.8 µM 5.25E-4 Golgi 55 8.95E-4
18 SGTC_366 0181-0206 3.11 4.3 µM 5.45E-4 Golgi 86 9.27E-4
19 SGTC_567 1080-0542 3.07 68.4 µM 6.39E-4 39 0.00107
20 SGTC_1210 3013-0140 3.06 750.0 nM 6.55E-4 32 0.00110

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.22E-14 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.117 8.84E-12 YAL067C SEO1 hom Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
0.104 1.31E-9 YNL254C RTC4 hom Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.102 3.24E-9 YGR278W CWC22 het Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein
0.099 1.07E-8 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.096 2.60E-8 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.093 5.95E-8 YOL043C NTG2 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication
0.088 3.05E-7 YOR307C SLY41 hom Protein involved in ER-to-Golgi transport
0.087 4.76E-7 YMR235C RNA1 het GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
0.085 7.93E-7 YDR209C_d YDR209C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
0.082 1.90E-6 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.081 2.92E-6 YFL040W_p YFL040W_p hom Putative transporter, member of the sugar porter family; YFL040W is not an essential gene
0.080 3.94E-6 YJR004C SAG1 hom Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
0.079 5.19E-6 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.078 5.40E-6 YBR264C YPT10 hom Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles