YDL220C / CDC13

Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL220C / CDC13

Click on Significant Values for Screen Details ID:SGTC_174|Compound:3553-0389|FD-Score:-3.12|P-value:7.65E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.69|P-value:1.02E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.39|P-value:3.20E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.35|P-value:3.25E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.90|P-value:3.96E-7 ID:SGTC_648|Compound:0375-0473|FD-Score:3.64|P-value:1.25E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.10|P-value:9.15E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.73|P-value:8.64E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:3.77|P-value:7.47E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.12|P-value:1.64E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.22|P-value:5.26E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.62|P-value:1.39E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.98|P-value:3.06E-5 ID:SGTC_1630|Compound:st005209|FD-Score:-3.79|P-value:5.88E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.34|P-value:3.89E-4 ID:SGTC_1740|Compound:st038286|FD-Score:5.29|P-value:4.82E-8 ID:SGTC_1747|Compound:st037496|FD-Score:7.39|P-value:4.35E-14 ID:SGTC_1963|Compound:st076565|FD-Score:3.17|P-value:7.06E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.17|P-value:7.06E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.47|P-value:2.38E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.55|P-value:1.53E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-4.01|P-value:2.30E-5 ID:SGTC_2601|Compound:securinine|FD-Score:3.37|P-value:3.48E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.48|P-value:3.27E-6 ID:SGTC_2693|Compound:st077581|FD-Score:-3.93|P-value:3.24E-5 ID:SGTC_2696|Compound:st077691|FD-Score:-4.18|P-value:1.09E-5 ID:SGTC_2882|Compound:9058044|FD-Score:4.13|P-value:1.62E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.44|P-value:2.70E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-3.47|P-value:2.12E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.62|P-value:1.60E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-4.23|P-value:8.55E-6 ID:SGTC_3008|Compound:9078912|FD-Score:4.27|P-value:8.65E-6 ID:SGTC_3015|Compound:9080845|FD-Score:3.66|P-value:1.16E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.27|P-value:4.39E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.45|P-value:2.24E-4 ID:SGTC_3165|Compound:9101544|FD-Score:4.31|P-value:7.20E-6 ID:SGTC_3189|Compound:9110682|FD-Score:4.44|P-value:3.84E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.84|P-value:5.54E-5 ID:SGTC_3230|Compound:9131665|FD-Score:-3.51|P-value:1.81E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.12|P-value:7.65E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.69|P-value:1.02E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.39|P-value:3.20E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.35|P-value:3.25E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.90|P-value:3.96E-7 ID:SGTC_648|Compound:0375-0473|FD-Score:3.64|P-value:1.25E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.10|P-value:9.15E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.73|P-value:8.64E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:3.77|P-value:7.47E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.12|P-value:1.64E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.22|P-value:5.26E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.62|P-value:1.39E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.98|P-value:3.06E-5 ID:SGTC_1630|Compound:st005209|FD-Score:-3.79|P-value:5.88E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.34|P-value:3.89E-4 ID:SGTC_1740|Compound:st038286|FD-Score:5.29|P-value:4.82E-8 ID:SGTC_1747|Compound:st037496|FD-Score:7.39|P-value:4.35E-14 ID:SGTC_1963|Compound:st076565|FD-Score:3.17|P-value:7.06E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.17|P-value:7.06E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.47|P-value:2.38E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.55|P-value:1.53E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-4.01|P-value:2.30E-5 ID:SGTC_2601|Compound:securinine|FD-Score:3.37|P-value:3.48E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.48|P-value:3.27E-6 ID:SGTC_2693|Compound:st077581|FD-Score:-3.93|P-value:3.24E-5 ID:SGTC_2696|Compound:st077691|FD-Score:-4.18|P-value:1.09E-5 ID:SGTC_2882|Compound:9058044|FD-Score:4.13|P-value:1.62E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.44|P-value:2.70E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-3.47|P-value:2.12E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.62|P-value:1.60E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-4.23|P-value:8.55E-6 ID:SGTC_3008|Compound:9078912|FD-Score:4.27|P-value:8.65E-6 ID:SGTC_3015|Compound:9080845|FD-Score:3.66|P-value:1.16E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.27|P-value:4.39E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.45|P-value:2.24E-4 ID:SGTC_3165|Compound:9101544|FD-Score:4.31|P-value:7.20E-6 ID:SGTC_3189|Compound:9110682|FD-Score:4.44|P-value:3.84E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.84|P-value:5.54E-5 ID:SGTC_3230|Compound:9131665|FD-Score:-3.51|P-value:1.81E-4

Top fitness defect scores for YDL220C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1747 st037496 7.39 66.6 µM 4.35E-14 1 7.14E-14 1.92
2 SGTC_1740 st038286 5.29 13.2 µM 4.82E-8 2 6.07E-8 0.49
3 SGTC_430 0958-0115 4.90 16.4 µM 3.96E-7 4 4.80E-7 0.32
4 SGTC_2944 9067346 4.62 25.6 µM 1.60E-6 7 1.89E-6 0.10
5 SGTC_2689 tacrolimus 4.48 100.0 µM 3.27E-6 8 3.81E-6 0.04
6 SGTC_3189 9110682 4.44 49.5 µM 3.84E-6 6 4.46E-6 0.01
7 SGTC_3165 9101544 4.31 49.5 µM 7.20E-6 2 8.27E-6 0.41
8 SGTC_3008 9078912 4.27 71.4 µM 8.65E-6 1 9.91E-6 0.37
9 SGTC_2882 9058044 4.13 58.4 µM 1.62E-5 3 1.83E-5 0.12
10 SGTC_1071 trifluoperazine 4.12 6.3 µM 1.64E-5 7 1.86E-5 0.10
11 SGTC_1505 k297-0037 3.98 20.6 µM 3.06E-5 4 3.43E-5 0.16
12 SGTC_3217 9129673 3.84 49.5 µM 5.54E-5 10 6.15E-5 0.06
13 SGTC_693 4161-2696 3.77 114.0 µM 7.47E-5 6 8.25E-5 0.21
14 SGTC_668 1682-0499 3.73 62.6 µM 8.64E-5 5 9.51E-5 0.16
15 SGTC_334 1502-1024 3.69 68.5 µM 1.02E-4 2 1.12E-4 0.13
16 SGTC_3015 9080845 3.66 49.5 µM 1.16E-4 4 1.27E-4 0.28
17 SGTC_648 0375-0473 3.64 33.3 µM 1.25E-4 9 1.37E-4 0.31
18 SGTC_2120 5538279 3.47 152.0 µM 2.38E-4 7 2.58E-4 0.05
19 SGTC_2913 7966556 3.44 36.6 µM 2.70E-4 60S ribosome export 11 2.92E-4 0.18
20 SGTC_424 splitomicin 3.39 100.0 mM 3.20E-4 6 3.45E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.203 1.21E-32 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.176 9.73E-25 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.154 3.58E-19 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.131 2.37E-14 YLR071C RGR1 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
0.124 5.53E-13 YDL208W NHP2 het Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
0.112 7.77E-11 YDL235C YPD1 het Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
0.110 1.88E-10 YPL228W CET1 het Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.109 2.26E-10 YFR003C YPI1 het Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance
0.100 5.57E-9 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.096 2.76E-8 YOR180C DCI1 hom Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed
0.095 3.20E-8 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.091 1.11E-7 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.091 1.51E-7 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.090 1.77E-7 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
0.088 3.73E-7 YKL215C OXP1 hom 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress