YDL221W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL221W / YDL221W

Click on Significant Values for Screen Details ID:SGTC_167|Compound:3672-0051|FD-Score:4.03|P-value:9.27E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.68|P-value:3.99E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:2.96|P-value:8.32E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:4.15|P-value:5.06E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:3.19|P-value:3.49E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.33|P-value:2.04E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.30|P-value:2.24E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:4.45|P-value:1.08E-6 ID:SGTC_656|Compound:4090-1979|FD-Score:-3.24|P-value:2.55E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.17|P-value:3.81E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.26|P-value:2.62E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.79|P-value:2.83E-5 ID:SGTC_1001|Compound:4048-4355|FD-Score:2.99|P-value:7.43E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.13|P-value:4.39E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.25|P-value:2.54E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.05|P-value:5.42E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.05|P-value:5.88E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.77|P-value:3.06E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.55|P-value:8.02E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.72|P-value:3.84E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.90|P-value:1.67E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:2.95|P-value:8.68E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.05|P-value:8.37E-6 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.09|P-value:6.92E-6 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.23|P-value:3.05E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.08|P-value:5.40E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:2.95|P-value:8.60E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.25|P-value:2.73E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.57|P-value:6.48E-5 ID:SGTC_1961|Compound:st076550|FD-Score:4.62|P-value:4.32E-7 ID:SGTC_1991|Compound:st073000|FD-Score:-2.98|P-value:6.95E-4 ID:SGTC_2098|Compound:5376439|FD-Score:-3.46|P-value:1.04E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.34|P-value:1.94E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.22|P-value:3.16E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.27|P-value:2.53E-4 ID:SGTC_2204|Compound:7233102|FD-Score:4.35|P-value:1.89E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.09|P-value:5.19E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.32|P-value:2.07E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.31|P-value:2.18E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.95|P-value:6.81E-8 ID:SGTC_2428|Compound:5615643|FD-Score:-4.38|P-value:1.41E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-2.92|P-value:8.77E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.55|P-value:7.29E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.09|P-value:4.65E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.14|P-value:5.42E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:2.96|P-value:8.29E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.19|P-value:4.21E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.16|P-value:3.95E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.02|P-value:6.70E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.30|P-value:2.31E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.24|P-value:2.57E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.86|P-value:1.14E-7 ID:SGTC_3331|Compound:9141060|FD-Score:-3.03|P-value:5.94E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.03|P-value:9.27E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.68|P-value:3.99E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:2.96|P-value:8.32E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:4.15|P-value:5.06E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:3.19|P-value:3.49E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.33|P-value:2.04E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.30|P-value:2.24E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:4.45|P-value:1.08E-6 ID:SGTC_656|Compound:4090-1979|FD-Score:-3.24|P-value:2.55E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.17|P-value:3.81E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.26|P-value:2.62E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.79|P-value:2.83E-5 ID:SGTC_1001|Compound:4048-4355|FD-Score:2.99|P-value:7.43E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.13|P-value:4.39E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.25|P-value:2.54E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.05|P-value:5.42E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.05|P-value:5.88E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.77|P-value:3.06E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.55|P-value:8.02E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.72|P-value:3.84E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.90|P-value:1.67E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:2.95|P-value:8.68E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.05|P-value:8.37E-6 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.09|P-value:6.92E-6 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.23|P-value:3.05E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.08|P-value:5.40E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:2.95|P-value:8.60E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.25|P-value:2.73E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.57|P-value:6.48E-5 ID:SGTC_1961|Compound:st076550|FD-Score:4.62|P-value:4.32E-7 ID:SGTC_1991|Compound:st073000|FD-Score:-2.98|P-value:6.95E-4 ID:SGTC_2098|Compound:5376439|FD-Score:-3.46|P-value:1.04E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.34|P-value:1.94E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.22|P-value:3.16E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.27|P-value:2.53E-4 ID:SGTC_2204|Compound:7233102|FD-Score:4.35|P-value:1.89E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.09|P-value:5.19E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.32|P-value:2.07E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.31|P-value:2.18E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.95|P-value:6.81E-8 ID:SGTC_2428|Compound:5615643|FD-Score:-4.38|P-value:1.41E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-2.92|P-value:8.77E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.55|P-value:7.29E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.09|P-value:4.65E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.14|P-value:5.42E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:2.96|P-value:8.29E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.19|P-value:4.21E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.16|P-value:3.95E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.02|P-value:6.70E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.30|P-value:2.31E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.24|P-value:2.57E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.86|P-value:1.14E-7 ID:SGTC_3331|Compound:9141060|FD-Score:-3.03|P-value:5.94E-4

Top fitness defect scores for YDL221W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2406 ethylparaben 4.95 405.7 µM 6.81E-8 5 3.65E-7 0.49
2 SGTC_3319 9138450 4.86 16.8 µM 1.14E-7 2 5.78E-7 0.67
3 SGTC_1961 st076550 4.62 68.7 µM 4.32E-7 4 1.87E-6 0.16
4 SGTC_653 0203-0016 4.45 55.2 µM 1.08E-6 3 4.21E-6 0.78
5 SGTC_2204 7233102 4.35 200.0 µM 1.89E-6 60S ribosome export 3 6.92E-6 0.49
6 SGTC_2697 mebhydrolin 4.19 72.4 µM 4.21E-6 NEO1 5 1.41E-5 0.02
7 SGTC_362 0310-0100 4.15 9.0 µM 5.06E-6 RPP1 & pyrimidine depletion 7 1.66E-5 0.02
8 SGTC_2574 2',4'-dihydroxychalcone 4.14 14.6 µM 5.42E-6 9 1.76E-5 0.24
9 SGTC_1535 tetrahydropapaveroline hydrobromide 4.09 54.3 µM 6.92E-6 RPP1 & pyrimidine depletion 2 2.19E-5 0.52
10 SGTC_1531 st059297 4.05 52.4 µM 8.37E-6 3 2.59E-5 0.33
11 SGTC_167 3672-0051 4.03 66.2 µM 9.27E-6 8 2.83E-5 0.30
12 SGTC_1334 1486-0610 3.90 236.0 µM 1.67E-5 60S ribosome export 1 4.77E-5 0.32
13 SGTC_959 1222-0044 3.79 107.0 µM 2.83E-5 5 7.63E-5 0.09
14 SGTC_1203 3992-3522 3.77 103.0 µM 3.06E-5 13 8.16E-5 0.04
15 SGTC_1306 1185-0270 3.72 9.0 µM 3.84E-5 Golgi 13 9.98E-5 0.23
16 SGTC_1292 0kpi-0043 3.55 232.0 µM 8.02E-5 4 1.92E-4 0.05
17 SGTC_2196 6573537 3.34 42.7 µM 1.94E-4 copper-dependent oxidative stress 8 4.21E-4 0.15
18 SGTC_500 h-89 3.33 112.0 µM 2.04E-4 cell wall signaling 16 4.41E-4 0.08
19 SGTC_2330 7979373 3.32 200.0 µM 2.07E-4 60S ribosome export 16 4.46E-4 0.01
20 SGTC_2384 9036245 3.31 200.0 µM 2.18E-4 5 4.66E-4 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.35E-12 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.109 2.71E-10 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.100 6.82E-9 YCR023C YCR023C hom Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
0.098 1.12E-8 YMR278W PGM3 hom Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential
0.098 1.47E-8 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.091 1.46E-7 YJL032W_d YJL032W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase
0.083 1.68E-6 YIR009W MSL1 hom U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members
0.082 2.07E-6 YKL079W SMY1 hom Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
0.081 3.02E-6 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.078 5.73E-6 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.078 6.87E-6 YLR116W MSL5 het Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA
0.076 9.95E-6 YGR283C YGR283C hom Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus
0.074 1.64E-5 YMR028W TAP42 het Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
0.072 2.68E-5 YHR078W_p YHR078W_p hom High osmolarity-regulated gene of unknown function
0.072 2.94E-5 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p