YDL223C / HBT1

Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL223C / HBT1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:4.66|P-value:1.18E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.66|P-value:1.17E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.43|P-value:2.93E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:5.22|P-value:1.08E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:8.34|P-value:1.55E-14 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.94|P-value:3.74E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.94|P-value:1.84E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:10.90|P-value:1.97E-23 ID:SGTC_264|Compound:promethazine|FD-Score:20.70|P-value:6.90E-80 ID:SGTC_329|Compound:k048-0121|FD-Score:5.12|P-value:1.70E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:3.45|P-value:9.14E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.38|P-value:8.97E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.17|P-value:7.89E-5 ID:SGTC_512|Compound:prima-1|FD-Score:4.58|P-value:1.62E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:3.55|P-value:6.72E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.93|P-value:1.86E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:5.15|P-value:1.48E-6 ID:SGTC_816|Compound:0325-0417|FD-Score:3.54|P-value:6.92E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.74|P-value:3.63E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.92|P-value:1.94E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:4.51|P-value:2.18E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:4.14|P-value:8.85E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.63|P-value:5.09E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:6.78|P-value:3.54E-10 ID:SGTC_948|Compound:3448-0295|FD-Score:5.42|P-value:4.30E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:3.70|P-value:4.03E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.60|P-value:4.41E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.67|P-value:3.43E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.39|P-value:8.60E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.74|P-value:8.46E-6 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.48|P-value:2.43E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.13|P-value:9.23E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:6.37|P-value:3.55E-9 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.03|P-value:1.33E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.91|P-value:4.23E-6 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.51|P-value:7.50E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.99|P-value:1.50E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.93|P-value:1.87E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.55|P-value:1.84E-5 ID:SGTC_1519|Compound:esterone|FD-Score:4.41|P-value:3.23E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.55|P-value:6.57E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.64|P-value:5.01E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.67|P-value:3.49E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.86|P-value:1.80E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:13.20|P-value:1.59E-33 ID:SGTC_1940|Compound:st075990|FD-Score:-3.81|P-value:2.20E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.65|P-value:4.74E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.73|P-value:2.86E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-4.00|P-value:1.12E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.49|P-value:7.99E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.65|P-value:9.13E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.86|P-value:1.80E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.16|P-value:1.43E-6 ID:SGTC_2671|Compound:danthron|FD-Score:4.91|P-value:4.23E-6 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:4.53|P-value:2.05E-5 ID:SGTC_2691|Compound:st077356|FD-Score:3.61|P-value:5.40E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.12|P-value:9.42E-5 ID:SGTC_2801|Compound:7907800|FD-Score:3.77|P-value:3.23E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.68|P-value:4.36E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.28|P-value:5.25E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.94|P-value:1.78E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.72|P-value:3.78E-4 ID:SGTC_3040|Compound:9091894|FD-Score:7.33|P-value:1.30E-11 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.41|P-value:2.35E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.65|P-value:4.87E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.50|P-value:2.23E-5 ID:SGTC_3318|Compound:9139014|FD-Score:6.45|P-value:2.27E-9 ID:SGTC_3324|Compound:9138759|FD-Score:5.86|P-value:5.12E-8 ID:SGTC_3334|Compound:9142812|FD-Score:5.63|P-value:1.63E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:4.66|P-value:1.18E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.66|P-value:1.17E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.43|P-value:2.93E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:5.22|P-value:1.08E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:8.34|P-value:1.55E-14 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.94|P-value:3.74E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.94|P-value:1.84E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:10.90|P-value:1.97E-23 ID:SGTC_264|Compound:promethazine|FD-Score:20.70|P-value:6.90E-80 ID:SGTC_329|Compound:k048-0121|FD-Score:5.12|P-value:1.70E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:3.45|P-value:9.14E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.38|P-value:8.97E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.17|P-value:7.89E-5 ID:SGTC_512|Compound:prima-1|FD-Score:4.58|P-value:1.62E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:3.55|P-value:6.72E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.93|P-value:1.86E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:5.15|P-value:1.48E-6 ID:SGTC_816|Compound:0325-0417|FD-Score:3.54|P-value:6.92E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.74|P-value:3.63E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.92|P-value:1.94E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:4.51|P-value:2.18E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:4.14|P-value:8.85E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.63|P-value:5.09E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:6.78|P-value:3.54E-10 ID:SGTC_948|Compound:3448-0295|FD-Score:5.42|P-value:4.30E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:3.70|P-value:4.03E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.60|P-value:4.41E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.67|P-value:3.43E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.39|P-value:8.60E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.74|P-value:8.46E-6 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.48|P-value:2.43E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.13|P-value:9.23E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:6.37|P-value:3.55E-9 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.03|P-value:1.33E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.91|P-value:4.23E-6 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.51|P-value:7.50E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.99|P-value:1.50E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.93|P-value:1.87E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.55|P-value:1.84E-5 ID:SGTC_1519|Compound:esterone|FD-Score:4.41|P-value:3.23E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.55|P-value:6.57E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.64|P-value:5.01E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.67|P-value:3.49E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.86|P-value:1.80E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:13.20|P-value:1.59E-33 ID:SGTC_1940|Compound:st075990|FD-Score:-3.81|P-value:2.20E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.65|P-value:4.74E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.73|P-value:2.86E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-4.00|P-value:1.12E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.49|P-value:7.99E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.65|P-value:9.13E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.86|P-value:1.80E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.16|P-value:1.43E-6 ID:SGTC_2671|Compound:danthron|FD-Score:4.91|P-value:4.23E-6 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:4.53|P-value:2.05E-5 ID:SGTC_2691|Compound:st077356|FD-Score:3.61|P-value:5.40E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.12|P-value:9.42E-5 ID:SGTC_2801|Compound:7907800|FD-Score:3.77|P-value:3.23E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.68|P-value:4.36E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.28|P-value:5.25E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.94|P-value:1.78E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.72|P-value:3.78E-4 ID:SGTC_3040|Compound:9091894|FD-Score:7.33|P-value:1.30E-11 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.41|P-value:2.35E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.65|P-value:4.87E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.50|P-value:2.23E-5 ID:SGTC_3318|Compound:9139014|FD-Score:6.45|P-value:2.27E-9 ID:SGTC_3324|Compound:9138759|FD-Score:5.86|P-value:5.12E-8 ID:SGTC_3334|Compound:9142812|FD-Score:5.63|P-value:1.63E-7

Top fitness defect scores for YDL223C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_264 promethazine 20.70 12.5 mM 6.90E-80 DNA intercalators 3 1.70E-95
2 SGTC_1926 methyl fluorone black 13.20 53.6 µM 1.59E-33 DNA intercalators 2 6.14E-40
3 SGTC_257 daunorubicin 10.90 18.5 µM 1.97E-23 anthracycline transcription coupled DNA repair 2 7.68E-28
4 SGTC_145 3737-0113 8.34 38.4 µM 1.55E-14 DNA intercalators 6 3.56E-17
5 SGTC_3040 9091894 7.33 49.5 µM 1.30E-11 DNA intercalators 4 1.14E-13
6 SGTC_943 3253-1379 6.78 105.0 µM 3.54E-10 3 5.96E-12
7 SGTC_3318 9139014 6.45 38.6 µM 2.27E-9 3 5.52E-11
8 SGTC_1340 1486-1359 6.37 257.0 µM 3.55E-9 1 9.41E-11
9 SGTC_3324 9138759 5.86 60.8 µM 5.12E-8 3 2.30E-9
10 SGTC_3334 9142812 5.63 21.9 µM 1.63E-7 7 9.25E-9
11 SGTC_948 3448-0295 5.42 75.3 µM 4.30E-7 7 2.95E-8
12 SGTC_144 4161-2749 5.22 112.4 µM 1.08E-6 DNA intercalators 8 8.85E-8
13 SGTC_2666 tannic acid 5.16 100.0 µM 1.43E-6 iron homeostasis 18 1.25E-7
14 SGTC_804 1595-0054 5.15 20.9 µM 1.48E-6 sphingolipid biosynthesis & PDR1 18 1.30E-7
15 SGTC_329 k048-0121 5.12 21.3 µM 1.70E-6 RSC & ERG11 5 1.53E-7
16 SGTC_255 tunicamycin 4.94 200.5 nM 3.74E-6 unfolded protein response 45 3.94E-7
17 SGTC_2671 danthron 4.91 100.0 µM 4.23E-6 DNA damage response 25 4.55E-7
18 SGTC_1468 k284-1086 4.91 134.0 µM 4.23E-6 DNA intercalators 12 4.56E-7
19 SGTC_1290 0986-0249 4.74 10.2 µM 8.46E-6 DNA intercalators 9 1.04E-6
20 SGTC_77 0828-0286 4.66 12.5 µM 1.17E-5 TSC3-RPN4 17 1.55E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.545 2.81E-258 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.540 2.89E-252 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.505 5.11E-216 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.480 7.07E-193 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.468 6.88E-182 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.433 4.41E-153 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.393 1.09E-123 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.391 1.37E-122 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.364 1.78E-105 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.347 2.84E-95 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.343 4.80E-93 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.341 7.58E-92 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.320 2.57E-80 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.287 1.13E-64 YLR133W CKI1 hom Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication
0.286 3.80E-64 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene