YDL225W / SHS1

Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL225W / SHS1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.42|P-value:4.34E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:2.84|P-value:5.49E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.33|P-value:6.04E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.17|P-value:1.27E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-3.63|P-value:1.44E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.23|P-value:1.04E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.60|P-value:5.67E-8 ID:SGTC_812|Compound:4251-0442|FD-Score:3.51|P-value:2.83E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.89|P-value:9.86E-9 ID:SGTC_923|Compound:1900-2434|FD-Score:-2.76|P-value:7.26E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.69|P-value:9.43E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.69|P-value:1.13E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.21|P-value:1.16E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.30|P-value:3.86E-7 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.27|P-value:8.16E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.82|P-value:6.13E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-2.83|P-value:5.41E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:2.77|P-value:7.43E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.65|P-value:3.79E-11 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.13|P-value:9.41E-7 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.30|P-value:6.89E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-2.87|P-value:4.59E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.27|P-value:8.54E-5 ID:SGTC_1914|Compound:st062367|FD-Score:3.86|P-value:4.60E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.87|P-value:4.27E-6 ID:SGTC_1966|Compound:st070145|FD-Score:-3.06|P-value:2.06E-4 ID:SGTC_1996|Compound:st072960|FD-Score:2.81|P-value:6.22E-4 ID:SGTC_2109|Compound:5483026|FD-Score:5.52|P-value:1.14E-10 ID:SGTC_2118|Compound:5526350|FD-Score:3.33|P-value:6.59E-5 ID:SGTC_2141|Compound:5621638|FD-Score:3.10|P-value:1.84E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.63|P-value:1.55E-5 ID:SGTC_2339|Compound:9000433|FD-Score:2.82|P-value:6.00E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.05|P-value:1.62E-6 ID:SGTC_2356|Compound:9061756|FD-Score:4.06|P-value:1.59E-6 ID:SGTC_2401|Compound:5128683|FD-Score:-2.79|P-value:6.35E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.08|P-value:1.89E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.12|P-value:1.55E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.13|P-value:1.60E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:2.80|P-value:6.67E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.59|P-value:6.81E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.72|P-value:8.90E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:2.72|P-value:8.92E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.51|P-value:2.57E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.96|P-value:3.33E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-4.03|P-value:1.68E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-4.30|P-value:3.57E-7 ID:SGTC_2803|Compound:7707263|FD-Score:-3.52|P-value:2.43E-5 ID:SGTC_2820|Compound:7989630|FD-Score:3.61|P-value:1.71E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.82|P-value:5.64E-6 ID:SGTC_2894|Compound:9048625|FD-Score:3.20|P-value:1.19E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.96|P-value:2.74E-6 ID:SGTC_2989|Compound:9073649|FD-Score:3.15|P-value:1.47E-4 ID:SGTC_3125|Compound:9127534|FD-Score:2.85|P-value:5.33E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-2.86|P-value:4.76E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.38|P-value:3.16E-10 ID:SGTC_65|Compound:0798-0905|FD-Score:3.42|P-value:4.34E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:2.84|P-value:5.49E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.33|P-value:6.04E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.17|P-value:1.27E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-3.63|P-value:1.44E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.23|P-value:1.04E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.60|P-value:5.67E-8 ID:SGTC_812|Compound:4251-0442|FD-Score:3.51|P-value:2.83E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.89|P-value:9.86E-9 ID:SGTC_923|Compound:1900-2434|FD-Score:-2.76|P-value:7.26E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.69|P-value:9.43E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.69|P-value:1.13E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.21|P-value:1.16E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.30|P-value:3.86E-7 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.27|P-value:8.16E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.82|P-value:6.13E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-2.83|P-value:5.41E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:2.77|P-value:7.43E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.65|P-value:3.79E-11 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.13|P-value:9.41E-7 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.30|P-value:6.89E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-2.87|P-value:4.59E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.27|P-value:8.54E-5 ID:SGTC_1914|Compound:st062367|FD-Score:3.86|P-value:4.60E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.87|P-value:4.27E-6 ID:SGTC_1966|Compound:st070145|FD-Score:-3.06|P-value:2.06E-4 ID:SGTC_1996|Compound:st072960|FD-Score:2.81|P-value:6.22E-4 ID:SGTC_2109|Compound:5483026|FD-Score:5.52|P-value:1.14E-10 ID:SGTC_2118|Compound:5526350|FD-Score:3.33|P-value:6.59E-5 ID:SGTC_2141|Compound:5621638|FD-Score:3.10|P-value:1.84E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.63|P-value:1.55E-5 ID:SGTC_2339|Compound:9000433|FD-Score:2.82|P-value:6.00E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.05|P-value:1.62E-6 ID:SGTC_2356|Compound:9061756|FD-Score:4.06|P-value:1.59E-6 ID:SGTC_2401|Compound:5128683|FD-Score:-2.79|P-value:6.35E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.08|P-value:1.89E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.12|P-value:1.55E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.13|P-value:1.60E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:2.80|P-value:6.67E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.59|P-value:6.81E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.72|P-value:8.90E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:2.72|P-value:8.92E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.51|P-value:2.57E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.96|P-value:3.33E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-4.03|P-value:1.68E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-4.30|P-value:3.57E-7 ID:SGTC_2803|Compound:7707263|FD-Score:-3.52|P-value:2.43E-5 ID:SGTC_2820|Compound:7989630|FD-Score:3.61|P-value:1.71E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.82|P-value:5.64E-6 ID:SGTC_2894|Compound:9048625|FD-Score:3.20|P-value:1.19E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.96|P-value:2.74E-6 ID:SGTC_2989|Compound:9073649|FD-Score:3.15|P-value:1.47E-4 ID:SGTC_3125|Compound:9127534|FD-Score:2.85|P-value:5.33E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-2.86|P-value:4.76E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.38|P-value:3.16E-10

Top fitness defect scores for YDL225W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2109 5483026 5.52 200.0 µM 1.14E-10 RSC complex & mRNA processing 6 1.72E-8
2 SGTC_3211 9128781 5.38 49.5 µM 3.16E-10 27 3.75E-8
3 SGTC_839 0122-0028 4.89 230.0 µM 9.86E-9 RSC complex & mRNA processing 15 5.15E-7
4 SGTC_2564 betulinic acid 4.59 100.0 µM 6.81E-8 21 2.25E-6
5 SGTC_1301 naphtanilide LB 4.30 4.8 µM 3.86E-7 heme requiring 6 8.48E-6
6 SGTC_2356 9061756 4.06 189.0 µM 1.59E-6 9 2.50E-5
7 SGTC_2354 9060492 4.05 162.0 µM 1.62E-6 14 2.54E-5
8 SGTC_2896 9052656 3.96 71.4 µM 2.74E-6 endomembrane recycling 115 3.80E-5
9 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.87 70.1 µM 4.27E-6 25 5.33E-5
10 SGTC_1914 st062367 3.86 72.6 µM 4.60E-6 23 5.64E-5
11 SGTC_2828 7998861 3.82 71.4 µM 5.64E-6 19 6.60E-5
12 SGTC_1214 0358-0031 3.69 63.7 µM 1.13E-5 25 1.12E-4
13 SGTC_2337 9009472 3.63 200.0 µM 1.55E-5 47 1.43E-4
14 SGTC_2820 7989630 3.61 71.4 µM 1.71E-5 ERG2 33 1.55E-4
15 SGTC_812 4251-0442 3.51 148.0 µM 2.83E-5 16 2.27E-4
16 SGTC_65 0798-0905 3.42 35.0 µM 4.34E-5 calcium & mitochondrial duress 122 3.16E-4
17 SGTC_2118 5526350 3.33 200.0 µM 6.59E-5 31 4.35E-4
18 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 3.27 67.5 µM 8.54E-5 73 5.31E-4
19 SGTC_658 3253-0951 3.23 102.0 µM 1.04E-4 calcium & mitochondrial duress 98 6.16E-4
20 SGTC_1262 0737-0114 3.21 49.6 µM 1.16E-4 51 6.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 5.03E-45 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.234 7.32E-43 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.232 3.52E-42 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.227 2.29E-40 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.206 1.63E-33 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.203 1.78E-32 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.201 5.60E-32 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.194 8.63E-30 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.193 1.71E-29 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.192 5.56E-29 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.188 5.97E-28 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.186 1.56E-27 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.184 8.68E-27 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.182 1.98E-26 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.182 2.23E-26 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth