YDL233W_p / MFG1

Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL233W / MFG1

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.13|P-value:4.89E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.80|P-value:2.87E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-2.96|P-value:8.56E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:-2.92|P-value:9.81E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.71|P-value:4.47E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.03|P-value:6.54E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.29|P-value:3.02E-6 ID:SGTC_706|Compound:4262-0057|FD-Score:3.33|P-value:2.24E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.19|P-value:3.58E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.33|P-value:2.20E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.02|P-value:7.41E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.14|P-value:4.37E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.66|P-value:5.70E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.37|P-value:1.87E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.27|P-value:1.34E-8 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.94|P-value:9.62E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:9.07|P-value:4.80E-22 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.36|P-value:1.99E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.65|P-value:5.83E-5 ID:SGTC_1617|Compound:st002906|FD-Score:3.47|P-value:1.26E-4 ID:SGTC_1755|Compound:st041960|FD-Score:2.99|P-value:8.11E-4 ID:SGTC_1931|Compound:st074438|FD-Score:-2.98|P-value:7.84E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-2.95|P-value:9.00E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.23|P-value:3.15E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.33|P-value:2.19E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.68|P-value:5.11E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.19|P-value:3.80E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.26|P-value:2.89E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.71|P-value:4.60E-5 ID:SGTC_2315|Compound:7733312|FD-Score:3.38|P-value:1.84E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-4.09|P-value:7.61E-6 ID:SGTC_2816|Compound:7982706|FD-Score:4.54|P-value:8.18E-7 ID:SGTC_2817|Compound:7995342|FD-Score:2.95|P-value:9.49E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.07|P-value:6.11E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.05|P-value:6.40E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-4.25|P-value:3.42E-6 ID:SGTC_2945|Compound:9067681|FD-Score:-3.00|P-value:7.45E-4 ID:SGTC_2949|Compound:9072542|FD-Score:5.87|P-value:2.95E-10 ID:SGTC_3012|Compound:9080433|FD-Score:3.06|P-value:6.19E-4 ID:SGTC_3097|Compound:9117246|FD-Score:4.06|P-value:9.20E-6 ID:SGTC_3193|Compound:9111931|FD-Score:4.33|P-value:2.48E-6 ID:SGTC_3244|Compound:9134489|FD-Score:3.15|P-value:4.54E-4 ID:SGTC_3268|Compound:9137683|FD-Score:-3.13|P-value:4.50E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.13|P-value:4.89E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.80|P-value:2.87E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-2.96|P-value:8.56E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:-2.92|P-value:9.81E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.71|P-value:4.47E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.03|P-value:6.54E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.29|P-value:3.02E-6 ID:SGTC_706|Compound:4262-0057|FD-Score:3.33|P-value:2.24E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.19|P-value:3.58E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.33|P-value:2.20E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.02|P-value:7.41E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.14|P-value:4.37E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.66|P-value:5.70E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.37|P-value:1.87E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.27|P-value:1.34E-8 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.94|P-value:9.62E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:9.07|P-value:4.80E-22 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.36|P-value:1.99E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.65|P-value:5.83E-5 ID:SGTC_1617|Compound:st002906|FD-Score:3.47|P-value:1.26E-4 ID:SGTC_1755|Compound:st041960|FD-Score:2.99|P-value:8.11E-4 ID:SGTC_1931|Compound:st074438|FD-Score:-2.98|P-value:7.84E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-2.95|P-value:9.00E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.23|P-value:3.15E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.33|P-value:2.19E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.68|P-value:5.11E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.19|P-value:3.80E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.26|P-value:2.89E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.71|P-value:4.60E-5 ID:SGTC_2315|Compound:7733312|FD-Score:3.38|P-value:1.84E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-4.09|P-value:7.61E-6 ID:SGTC_2816|Compound:7982706|FD-Score:4.54|P-value:8.18E-7 ID:SGTC_2817|Compound:7995342|FD-Score:2.95|P-value:9.49E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.07|P-value:6.11E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.05|P-value:6.40E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-4.25|P-value:3.42E-6 ID:SGTC_2945|Compound:9067681|FD-Score:-3.00|P-value:7.45E-4 ID:SGTC_2949|Compound:9072542|FD-Score:5.87|P-value:2.95E-10 ID:SGTC_3012|Compound:9080433|FD-Score:3.06|P-value:6.19E-4 ID:SGTC_3097|Compound:9117246|FD-Score:4.06|P-value:9.20E-6 ID:SGTC_3193|Compound:9111931|FD-Score:4.33|P-value:2.48E-6 ID:SGTC_3244|Compound:9134489|FD-Score:3.15|P-value:4.54E-4 ID:SGTC_3268|Compound:9137683|FD-Score:-3.13|P-value:4.50E-4

Top fitness defect scores for YDL233W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1381 2324-0066 9.07 62.1 µM 4.80E-22 2 5.76E-20
2 SGTC_2949 9072542 5.87 2.2 µM 2.95E-10 TSC3-RPN4 7 2.21E-9
3 SGTC_1369 1866-0067 5.27 208.0 µM 1.34E-8 RPP1 & pyrimidine depletion 17 6.83E-8
4 SGTC_2816 7982706 4.54 58.4 µM 8.18E-7 azole & statin 36 2.76E-6
5 SGTC_3193 9111931 4.33 49.5 µM 2.48E-6 16 7.51E-6
6 SGTC_604 1000-0114 4.29 314.0 µM 3.02E-6 13 8.95E-6
7 SGTC_3097 9117246 4.06 49.5 µM 9.20E-6 8 2.45E-5
8 SGTC_212 3807-4682 3.71 38.8 µM 4.47E-5 tubulin folding & SWR complex 84 1.02E-4
9 SGTC_2147 5545932 3.71 89.7 µM 4.60E-5 ergosterol biosynthesis 18 1.04E-4
10 SGTC_2080 5212524 3.68 12.4 µM 5.11E-5 copper-dependent oxidative stress 18 1.15E-4
11 SGTC_1230 0170-0365 3.66 3.8 µM 5.70E-5 endomembrane recycling 84 1.27E-4
12 SGTC_1514 1189-1591 3.65 158.0 µM 5.83E-5 46 1.29E-4
13 SGTC_1617 st002906 3.47 78.0 µM 1.26E-4 39 2.59E-4
14 SGTC_2315 7733312 3.38 200.0 µM 1.84E-4 41 3.65E-4
15 SGTC_1347 1493-0251 3.37 600.0 nM 1.87E-4 mitochondrial response to ROS 30 3.71E-4
16 SGTC_1436 4092-1007 3.36 8.3 µM 1.99E-4 27 3.92E-4
17 SGTC_2073 5212005 3.33 126.0 µM 2.19E-4 14 4.28E-4
18 SGTC_779 1360-0071 3.33 233.0 µM 2.20E-4 fatty acid desaturase (OLE1) 58 4.30E-4
19 SGTC_706 4262-0057 3.33 46.9 µM 2.24E-4 fatty acid desaturase (OLE1) 64 4.37E-4
20 SGTC_2108 5365811 3.26 200.0 µM 2.89E-4 41 5.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 6.28E-16 YOL098C_p YOL098C_p hom Putative metalloprotease
0.117 1.26E-11 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.115 2.40E-11 YBL093C ROX3 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme
0.110 1.76E-10 YAL049C AIM2 hom Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor
0.110 1.84E-10 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.106 7.07E-10 YLR045C STU2 het Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
0.100 5.68E-9 YPR186C PZF1 het Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA
0.098 1.46E-8 YHR122W CIA2 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
0.095 3.27E-8 YMR290W-A_d YMR290W-A_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
0.094 5.47E-8 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.093 7.69E-8 YBR104W YMC2 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication
0.091 1.48E-7 YPL099C AIM43 hom Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
0.089 2.12E-7 YPR027C_p YPR027C_p hom Putative protein of unknown function
0.088 3.23E-7 YHR176W FMO1 hom Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
0.087 4.60E-7 YOR350C MNE1 hom Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA