YDL235C / YPD1

Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL235C / YPD1

Click on Significant Values for Screen Details ID:SGTC_117|Compound:lucigenin|FD-Score:3.15|P-value:9.17E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:4.12|P-value:2.25E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.10|P-value:2.39E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.05|P-value:9.87E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-4.25|P-value:8.75E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.08|P-value:9.07E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:-3.99|P-value:2.80E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:-4.41|P-value:4.31E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:3.60|P-value:1.85E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-5.13|P-value:1.16E-7 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.39|P-value:2.98E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.30|P-value:4.15E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:-3.43|P-value:2.60E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.59|P-value:1.43E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-3.40|P-value:2.91E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.29|P-value:4.36E-4 ID:SGTC_1832|Compound:st054113|FD-Score:-3.36|P-value:3.39E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-3.58|P-value:1.48E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.61|P-value:1.29E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.23|P-value:5.37E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.45|P-value:2.40E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.64|P-value:1.58E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.60|P-value:1.84E-4 ID:SGTC_2103|Compound:5378138|FD-Score:-4.22|P-value:1.00E-5 ID:SGTC_2143|Compound:5623677|FD-Score:-3.65|P-value:1.09E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.16|P-value:1.82E-5 ID:SGTC_2384|Compound:9036245|FD-Score:-3.80|P-value:6.14E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.57|P-value:1.99E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.42|P-value:2.72E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-4.31|P-value:6.69E-6 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.06|P-value:9.59E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-6.01|P-value:7.05E-10 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.17|P-value:8.62E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.57|P-value:2.01E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.56|P-value:2.12E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.91|P-value:3.94E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.66|P-value:1.09E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.49|P-value:2.09E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.89|P-value:5.68E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-3.28|P-value:4.55E-4 ID:SGTC_3002|Compound:9075603|FD-Score:4.63|P-value:2.19E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.54|P-value:2.25E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.78|P-value:8.87E-5 ID:SGTC_3230|Compound:9131665|FD-Score:-3.11|P-value:8.10E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-3.09|P-value:8.76E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.15|P-value:9.17E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:4.12|P-value:2.25E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.10|P-value:2.39E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.05|P-value:9.87E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-4.25|P-value:8.75E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.08|P-value:9.07E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:-3.99|P-value:2.80E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:-4.41|P-value:4.31E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:3.60|P-value:1.85E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-5.13|P-value:1.16E-7 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.39|P-value:2.98E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.30|P-value:4.15E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:-3.43|P-value:2.60E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.59|P-value:1.43E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-3.40|P-value:2.91E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.29|P-value:4.36E-4 ID:SGTC_1832|Compound:st054113|FD-Score:-3.36|P-value:3.39E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-3.58|P-value:1.48E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.61|P-value:1.29E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.23|P-value:5.37E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.45|P-value:2.40E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.64|P-value:1.58E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.60|P-value:1.84E-4 ID:SGTC_2103|Compound:5378138|FD-Score:-4.22|P-value:1.00E-5 ID:SGTC_2143|Compound:5623677|FD-Score:-3.65|P-value:1.09E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.16|P-value:1.82E-5 ID:SGTC_2384|Compound:9036245|FD-Score:-3.80|P-value:6.14E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.57|P-value:1.99E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.42|P-value:2.72E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-4.31|P-value:6.69E-6 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.06|P-value:9.59E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-6.01|P-value:7.05E-10 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.17|P-value:8.62E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.57|P-value:2.01E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.56|P-value:2.12E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.91|P-value:3.94E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.66|P-value:1.09E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.49|P-value:2.09E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.89|P-value:5.68E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-3.28|P-value:4.55E-4 ID:SGTC_3002|Compound:9075603|FD-Score:4.63|P-value:2.19E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.54|P-value:2.25E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.78|P-value:8.87E-5 ID:SGTC_3230|Compound:9131665|FD-Score:-3.11|P-value:8.10E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-3.09|P-value:8.76E-4

Top fitness defect scores for YDL235C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3002 9075603 4.63 71.4 µM 2.19E-6 2 1.85E-6 0.30
2 SGTC_2157 5649910 4.16 96.4 µM 1.82E-5 3 1.56E-5 0.02
3 SGTC_324 1315-0088 4.12 19.6 µM 2.25E-5 RSC & ERG11 11 1.93E-5 0.13
4 SGTC_390 dec-rvkr-cmk 4.10 16.7 µM 2.39E-5 calcium & mitochondrial duress 5 2.06E-5 0.22
5 SGTC_2894 9048625 3.89 32.5 µM 5.68E-5 10 4.92E-5 0.06
6 SGTC_3217 9129673 3.78 49.5 µM 8.87E-5 11 7.70E-5 0.02
7 SGTC_2085 5307070 3.64 144.1 µM 1.58E-4 superoxide 11 1.38E-4 0.14
8 SGTC_2090 5301565 3.60 104.5 µM 1.84E-4 TSC3-RPN4 7 1.61E-4 0.02
9 SGTC_997 3996-0078 3.60 137.0 µM 1.85E-4 12 1.61E-4 0.14
10 SGTC_2572 astragaloside iv 3.57 100.0 µM 2.01E-4 12 1.76E-4 0.21
11 SGTC_2592 piperlongumine 3.56 83.3 µM 2.12E-4 TSC3-RPN4 9 1.86E-4 0.02
12 SGTC_3197 9113331 3.54 49.5 µM 2.25E-4 14 1.97E-4 0.00
13 SGTC_2569 tetrandrine 3.17 100.0 µM 8.62E-4 11 7.63E-4 0.05
14 SGTC_117 lucigenin 3.15 22.1 µM 9.17E-4 redox potentiating 13 8.12E-4 0.22
15 SGTC_2591 skatole 3.00 100.0 µM 0.00152 18 0.00135 0.04
16 SGTC_2842 9000675 2.94 19.5 µM 0.00183 21 0.00163 0.05
17 SGTC_334 1502-1024 2.89 68.5 µM 0.00215 10 0.00192 0.01
18 SGTC_2540 epiandrosterone 2.83 100.0 µM 0.00264 20 0.00236 0.01
19 SGTC_322 k048-0136 2.81 19.3 µM 0.00279 RSC & ERG11 19 0.00249 0.01
20 SGTC_2891 9063876 2.75 19.5 µM 0.00336 8 0.00301 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 3.77E-26 YML054C CYB2 hom Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
0.157 6.73E-20 YOR373W NUD1 het Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance
0.130 3.85E-14 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.112 7.77E-11 YDL220C CDC13 het Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation
0.110 1.99E-10 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.109 2.70E-10 YFR003C YPI1 het Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance
0.107 4.29E-10 YOR054C VHS3 hom Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
0.103 1.94E-9 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.101 4.79E-9 YIR043C YIR043C hom Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
0.099 1.03E-8 YGL103W RPL28 het Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
0.097 1.62E-8 YLR349W_d YLR349W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
0.096 2.15E-8 YNL039W BDP1 het Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
0.094 5.28E-8 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.092 9.69E-8 YER155C BEM2 hom Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
0.092 1.02E-7 YLR328W NMA1 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication