YDL237W / AIM6

Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL237W / AIM6

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:-3.91|P-value:5.23E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.57|P-value:2.01E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.88|P-value:6.21E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.25|P-value:6.26E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.26|P-value:6.37E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.53|P-value:2.30E-8 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.49|P-value:2.81E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.24|P-value:6.84E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.14|P-value:9.25E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.39|P-value:4.01E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.54|P-value:2.20E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.54|P-value:2.38E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-4.23|P-value:1.35E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.71|P-value:1.24E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.27|P-value:1.25E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:4.42|P-value:6.36E-6 ID:SGTC_1721|Compound:st082152|FD-Score:3.92|P-value:5.29E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.24|P-value:6.60E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.71|P-value:1.15E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.42|P-value:3.50E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.15|P-value:8.97E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.52|P-value:3.96E-6 ID:SGTC_2333|Compound:9017922|FD-Score:-3.77|P-value:9.31E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.57|P-value:3.08E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.55|P-value:2.10E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-3.47|P-value:2.92E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.79|P-value:8.87E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.47|P-value:2.87E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.36|P-value:4.29E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.50|P-value:2.60E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-4.13|P-value:2.13E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.15|P-value:8.85E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.53|P-value:2.41E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.17|P-value:8.26E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.75|P-value:1.06E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.15|P-value:9.35E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.55|P-value:2.24E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.59|P-value:1.84E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.33|P-value:4.82E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.88|P-value:5.98E-5 ID:SGTC_3281|Compound:9140613|FD-Score:3.87|P-value:6.63E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:-3.91|P-value:5.23E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.57|P-value:2.01E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.88|P-value:6.21E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.25|P-value:6.26E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.26|P-value:6.37E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.53|P-value:2.30E-8 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.49|P-value:2.81E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.24|P-value:6.84E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.14|P-value:9.25E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.39|P-value:4.01E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.54|P-value:2.20E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.54|P-value:2.38E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-4.23|P-value:1.35E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.71|P-value:1.24E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.27|P-value:1.25E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:4.42|P-value:6.36E-6 ID:SGTC_1721|Compound:st082152|FD-Score:3.92|P-value:5.29E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.24|P-value:6.60E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.71|P-value:1.15E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.42|P-value:3.50E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.15|P-value:8.97E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.52|P-value:3.96E-6 ID:SGTC_2333|Compound:9017922|FD-Score:-3.77|P-value:9.31E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.57|P-value:3.08E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.55|P-value:2.10E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-3.47|P-value:2.92E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.79|P-value:8.87E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.47|P-value:2.87E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.36|P-value:4.29E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.50|P-value:2.60E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-4.13|P-value:2.13E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.15|P-value:8.85E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.53|P-value:2.41E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.17|P-value:8.26E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.75|P-value:1.06E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.15|P-value:9.35E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.55|P-value:2.24E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.59|P-value:1.84E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.33|P-value:4.82E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.88|P-value:5.98E-5 ID:SGTC_3281|Compound:9140613|FD-Score:3.87|P-value:6.63E-5

Top fitness defect scores for YDL237W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1027 k015-0025 5.53 8.7 µM 2.30E-8 7 1.62E-8
2 SGTC_2335 9018011 4.57 154.2 µM 3.08E-6 21 2.40E-6
3 SGTC_2331 7980721 4.52 200.0 µM 3.96E-6 14 3.09E-6
4 SGTC_1718 roemerine 4.42 11.9 µM 6.36E-6 redox potentiating 37 5.02E-6
5 SGTC_1717 st033143 4.27 58.0 µM 1.25E-5 31 9.99E-6
6 SGTC_1721 st082152 3.92 9.3 µM 5.29E-5 60S ribosome export 21 4.37E-5
7 SGTC_255 tunicamycin 3.88 200.5 nM 6.21E-5 unfolded protein response 76 5.14E-5
8 SGTC_3281 9140613 3.87 49.5 µM 6.63E-5 RPP1 & pyrimidine depletion 23 5.49E-5
9 SGTC_2505 galangin 3.79 7.9 µM 8.87E-5 RPP1 & pyrimidine depletion 9 7.40E-5
10 SGTC_2853 9015042 3.75 58.4 µM 1.06E-4 31 8.89E-5
11 SGTC_1637 st007924 3.71 17.4 µM 1.24E-4 32 1.04E-4
12 SGTC_2862 9027634 3.55 71.4 µM 2.24E-4 ERG2 42 1.90E-4
13 SGTC_1626 st003712 3.54 1.8 µM 2.38E-4 35 2.02E-4
14 SGTC_2837 9008476 3.53 45.5 µM 2.41E-4 50 2.05E-4
15 SGTC_1286 0929-0070 3.49 131.0 µM 2.81E-4 32 2.40E-4
16 SGTC_1479 0549-0158 3.39 134.0 µM 4.01E-4 55 3.45E-4
17 SGTC_836 0330-0104 3.26 1.4 µM 6.37E-4 33 5.54E-4
18 SGTC_1365 1672-3266 3.24 55.4 µM 6.84E-4 47 5.95E-4
19 SGTC_2858 9025781 3.15 9.0 µM 9.35E-4 sphingolipid biosynthesis & PDR1 156 8.19E-4
20 SGTC_263 alizarin 3.11 107.9 µM 0.00107 iron homeostasis 117 9.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.44E-15 YHL041W_d YHL041W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.133 1.01E-14 YGR144W THI4 hom Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents
0.130 4.41E-14 YNL261W ORC5 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.116 2.00E-11 YJR149W_p YJR149W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.109 2.45E-10 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.107 5.75E-10 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.101 5.36E-9 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.099 1.04E-8 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.099 1.05E-8 YHR124W NDT80 hom Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
0.098 1.16E-8 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.093 6.27E-8 YDR183W PLP1 hom Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators
0.086 6.27E-7 YPL048W CAM1 hom Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
0.085 8.57E-7 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.083 1.46E-6 YER011W TIR1 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
0.082 1.97E-6 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation