YDL238C / GUD1

Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL238C / GUD1

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:3.24|P-value:7.00E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.14|P-value:9.82E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:4.37|P-value:8.14E-6 ID:SGTC_196|Compound:k015-0023|FD-Score:3.80|P-value:8.77E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:4.31|P-value:1.06E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:-3.64|P-value:1.84E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.08|P-value:3.19E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:4.13|P-value:2.28E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.57|P-value:2.13E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.14|P-value:9.79E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.45|P-value:3.26E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.26|P-value:6.53E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.36|P-value:5.01E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-4.67|P-value:2.40E-6 ID:SGTC_856|Compound:0433-0016|FD-Score:4.52|P-value:4.11E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.37|P-value:8.17E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.64|P-value:1.83E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.54|P-value:2.59E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:7.57|P-value:4.58E-14 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.64|P-value:2.43E-6 ID:SGTC_1746|Compound:st038117|FD-Score:4.05|P-value:3.25E-5 ID:SGTC_1762|Compound:st045503|FD-Score:4.21|P-value:1.68E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.42|P-value:3.62E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.03|P-value:3.56E-5 ID:SGTC_1962|Compound:st076595|FD-Score:5.83|P-value:4.71E-9 ID:SGTC_1963|Compound:st076565|FD-Score:-3.40|P-value:4.35E-4 ID:SGTC_1987|Compound:st072290|FD-Score:-3.33|P-value:5.55E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.48|P-value:2.98E-4 ID:SGTC_2145|Compound:5634607|FD-Score:4.72|P-value:1.66E-6 ID:SGTC_2147|Compound:5545932|FD-Score:4.80|P-value:1.08E-6 ID:SGTC_2165|Compound:5727197|FD-Score:4.78|P-value:1.23E-6 ID:SGTC_2292|Compound:7671323|FD-Score:-3.29|P-value:6.33E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.37|P-value:4.36E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.33|P-value:5.03E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:5.22|P-value:1.32E-7 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.89|P-value:6.26E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.30|P-value:5.54E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.04|P-value:3.31E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.30|P-value:5.70E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.42|P-value:4.07E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.29|P-value:6.41E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.55|P-value:3.58E-6 ID:SGTC_2997|Compound:9067075|FD-Score:-3.17|P-value:9.55E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-3.98|P-value:4.80E-5 ID:SGTC_3195|Compound:9113082|FD-Score:-3.67|P-value:1.60E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.42|P-value:4.04E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.28|P-value:6.10E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.16|P-value:9.97E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.24|P-value:7.00E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.14|P-value:9.82E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:4.37|P-value:8.14E-6 ID:SGTC_196|Compound:k015-0023|FD-Score:3.80|P-value:8.77E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:4.31|P-value:1.06E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:-3.64|P-value:1.84E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.08|P-value:3.19E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:4.13|P-value:2.28E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.57|P-value:2.13E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.14|P-value:9.79E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.45|P-value:3.26E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.26|P-value:6.53E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.36|P-value:5.01E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-4.67|P-value:2.40E-6 ID:SGTC_856|Compound:0433-0016|FD-Score:4.52|P-value:4.11E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.37|P-value:8.17E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.64|P-value:1.83E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.54|P-value:2.59E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:7.57|P-value:4.58E-14 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.64|P-value:2.43E-6 ID:SGTC_1746|Compound:st038117|FD-Score:4.05|P-value:3.25E-5 ID:SGTC_1762|Compound:st045503|FD-Score:4.21|P-value:1.68E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.42|P-value:3.62E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.03|P-value:3.56E-5 ID:SGTC_1962|Compound:st076595|FD-Score:5.83|P-value:4.71E-9 ID:SGTC_1963|Compound:st076565|FD-Score:-3.40|P-value:4.35E-4 ID:SGTC_1987|Compound:st072290|FD-Score:-3.33|P-value:5.55E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.48|P-value:2.98E-4 ID:SGTC_2145|Compound:5634607|FD-Score:4.72|P-value:1.66E-6 ID:SGTC_2147|Compound:5545932|FD-Score:4.80|P-value:1.08E-6 ID:SGTC_2165|Compound:5727197|FD-Score:4.78|P-value:1.23E-6 ID:SGTC_2292|Compound:7671323|FD-Score:-3.29|P-value:6.33E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.37|P-value:4.36E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.33|P-value:5.03E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:5.22|P-value:1.32E-7 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.89|P-value:6.26E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.30|P-value:5.54E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.04|P-value:3.31E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.30|P-value:5.70E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.42|P-value:4.07E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.29|P-value:6.41E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.55|P-value:3.58E-6 ID:SGTC_2997|Compound:9067075|FD-Score:-3.17|P-value:9.55E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-3.98|P-value:4.80E-5 ID:SGTC_3195|Compound:9113082|FD-Score:-3.67|P-value:1.60E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.42|P-value:4.04E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.28|P-value:6.10E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.16|P-value:9.97E-4

Top fitness defect scores for YDL238C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1565 sinapyl alcohol 7.57 95.1 µM 4.58E-14 1 1.91E-14
2 SGTC_1962 st076595 5.83 64.5 µM 4.71E-9 redox potentiating 7 2.84E-9
3 SGTC_2557 derrustone 5.22 83.8 µM 1.32E-7 12 8.84E-8
4 SGTC_2147 5545932 4.80 89.7 µM 1.08E-6 ergosterol biosynthesis 4 7.74E-7
5 SGTC_2165 5727197 4.78 32.1 µM 1.23E-6 22 8.80E-7
6 SGTC_2145 5634607 4.72 200.0 µM 1.66E-6 2 1.20E-6
7 SGTC_1575 cyproterone acetate 4.64 48.0 µM 2.43E-6 9 1.78E-6
8 SGTC_2830 7992007 4.55 71.4 µM 3.58E-6 14 2.66E-6
9 SGTC_856 0433-0016 4.52 11.3 µM 4.11E-6 8 3.06E-6
10 SGTC_190 3970-0790 4.37 3.7 µM 8.14E-6 4 6.18E-6
11 SGTC_1451 4152-0210 4.37 104.0 µM 8.17E-6 15 6.21E-6
12 SGTC_212 3807-4682 4.31 38.8 µM 1.06E-5 tubulin folding & SWR complex 50 8.09E-6
13 SGTC_1762 st045503 4.21 25.5 µM 1.68E-5 21 1.30E-5
14 SGTC_288 1315-0019 4.13 35.1 µM 2.28E-5 RSC & ERG11 18 1.79E-5
15 SGTC_1746 st038117 4.05 42.0 µM 3.25E-5 30 2.57E-5
16 SGTC_2777 climbazole 4.04 1.5 µM 3.31E-5 iron homeostasis 46 2.62E-5
17 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 4.03 14.9 µM 3.56E-5 10 2.83E-5
18 SGTC_2558 carylophyllene oxide 3.89 100.0 µM 6.26E-5 13 5.05E-5
19 SGTC_196 k015-0023 3.80 18.1 µM 8.77E-5 PDR1 24 7.15E-5
20 SGTC_290 2043-6722 3.57 48.1 µM 2.13E-4 18 1.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.73E-11 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.103 1.84E-9 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.100 7.16E-9 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.090 1.57E-7 YOR219C STE13 hom Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
0.090 1.71E-7 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.090 1.90E-7 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.086 5.79E-7 YCL069W VBA3 hom Permease of basic amino acids in the vacuolar membrane
0.085 7.81E-7 YDL240W LRG1 hom Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
0.084 1.10E-6 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.082 2.13E-6 YPL211W NIP7 het Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
0.081 2.99E-6 YLL056C_p YLL056C_p hom Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
0.079 4.14E-6 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
0.079 5.12E-6 YGR130C YGR130C hom Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
0.077 8.30E-6 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.076 1.16E-5 YOR371C GPB1 hom Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication