YDL241W_p

Putative protein of unknown function; YDL241W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL241W / YDL241W

Click on Significant Values for Screen Details ID:SGTC_366|Compound:0181-0206|FD-Score:4.24|P-value:2.61E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:2.89|P-value:9.65E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-2.95|P-value:7.54E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.06|P-value:5.03E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.16|P-value:3.42E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.15|P-value:3.60E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-4.49|P-value:7.13E-7 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.56|P-value:6.36E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.98|P-value:9.60E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.21|P-value:2.82E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.88|P-value:1.50E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.78|P-value:2.48E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:2.94|P-value:7.98E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.79|P-value:2.34E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:-4.30|P-value:1.89E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.46|P-value:9.95E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.79|P-value:2.35E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.97|P-value:7.15E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.18|P-value:3.19E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.41|P-value:1.24E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.11|P-value:4.23E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:2.89|P-value:9.41E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.17|P-value:3.33E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.09|P-value:4.50E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.62|P-value:5.10E-5 ID:SGTC_1857|Compound:st056007|FD-Score:-3.03|P-value:5.62E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-3.57|P-value:6.32E-5 ID:SGTC_2035|Compound:5154463|FD-Score:4.64|P-value:3.12E-7 ID:SGTC_2057|Compound:5236571|FD-Score:2.91|P-value:8.89E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.63|P-value:3.31E-7 ID:SGTC_2096|Compound:5468907|FD-Score:3.27|P-value:2.25E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.10|P-value:4.25E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.00|P-value:6.25E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.46|P-value:1.00E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.42|P-value:1.19E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.21|P-value:2.86E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.14|P-value:3.72E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.28|P-value:2.15E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.31|P-value:1.85E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:5.01|P-value:3.64E-8 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.98|P-value:9.29E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.00|P-value:8.63E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.22|P-value:2.70E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-4.68|P-value:2.49E-7 ID:SGTC_2784|Compound:7567673|FD-Score:2.92|P-value:8.41E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.26|P-value:2.27E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.92|P-value:1.23E-5 ID:SGTC_2943|Compound:9068529|FD-Score:2.92|P-value:8.58E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.45|P-value:1.07E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.83|P-value:1.92E-5 ID:SGTC_3330|Compound:9141424|FD-Score:4.55|P-value:4.94E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:4.24|P-value:2.61E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:2.89|P-value:9.65E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-2.95|P-value:7.54E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.06|P-value:5.03E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.16|P-value:3.42E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.15|P-value:3.60E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-4.49|P-value:7.13E-7 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.56|P-value:6.36E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.98|P-value:9.60E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.21|P-value:2.82E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.88|P-value:1.50E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.78|P-value:2.48E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:2.94|P-value:7.98E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.79|P-value:2.34E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:-4.30|P-value:1.89E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.46|P-value:9.95E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.79|P-value:2.35E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.97|P-value:7.15E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.18|P-value:3.19E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.41|P-value:1.24E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.11|P-value:4.23E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:2.89|P-value:9.41E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.17|P-value:3.33E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.09|P-value:4.50E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.62|P-value:5.10E-5 ID:SGTC_1857|Compound:st056007|FD-Score:-3.03|P-value:5.62E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-3.57|P-value:6.32E-5 ID:SGTC_2035|Compound:5154463|FD-Score:4.64|P-value:3.12E-7 ID:SGTC_2057|Compound:5236571|FD-Score:2.91|P-value:8.89E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.63|P-value:3.31E-7 ID:SGTC_2096|Compound:5468907|FD-Score:3.27|P-value:2.25E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.10|P-value:4.25E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.00|P-value:6.25E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.46|P-value:1.00E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.42|P-value:1.19E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.21|P-value:2.86E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.14|P-value:3.72E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.28|P-value:2.15E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.31|P-value:1.85E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:5.01|P-value:3.64E-8 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.98|P-value:9.29E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.00|P-value:8.63E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.22|P-value:2.70E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-4.68|P-value:2.49E-7 ID:SGTC_2784|Compound:7567673|FD-Score:2.92|P-value:8.41E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.26|P-value:2.27E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.92|P-value:1.23E-5 ID:SGTC_2943|Compound:9068529|FD-Score:2.92|P-value:8.58E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.45|P-value:1.07E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.83|P-value:1.92E-5 ID:SGTC_3330|Compound:9141424|FD-Score:4.55|P-value:4.94E-7

Top fitness defect scores for YDL241W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2598 perillyl alcohol 5.01 100.0 µM 3.64E-8 11 2.72E-7
2 SGTC_2035 5154463 4.64 94.6 µM 3.12E-7 7 1.76E-6
3 SGTC_2066 5222451 4.63 176.0 µM 3.31E-7 heme biosynthesis & mitochondrial translocase 16 1.86E-6
4 SGTC_3330 9141424 4.55 71.4 µM 4.94E-7 amide catabolism 9 2.63E-6
5 SGTC_2588 indole-3-carbinol 4.31 100.0 µM 1.85E-6 34 8.32E-6
6 SGTC_366 0181-0206 4.24 4.3 µM 2.61E-6 Golgi 32 1.12E-5
7 SGTC_2603 homopterocarpin 4.00 100.0 µM 8.63E-6 37 3.18E-5
8 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 3.98 100.0 µM 9.29E-6 34 3.39E-5
9 SGTC_1033 k072-0102 3.88 21.3 µM 1.50E-5 60S ribosome export 25 5.16E-5
10 SGTC_3272 9137413 3.83 49.5 µM 1.92E-5 16 6.39E-5
11 SGTC_1237 0330-0133 3.79 46.1 µM 2.35E-5 ergosterol biosynthesis 30 7.60E-5
12 SGTC_1044 1222-0021 3.78 1.8 µM 2.48E-5 heme biosynthesis & mitochondrial translocase 43 7.99E-5
13 SGTC_1826 st055655 3.62 41.6 µM 5.10E-5 ERG2 51 1.50E-4
14 SGTC_1230 0170-0365 3.46 3.8 µM 9.95E-5 endomembrane recycling 95 2.68E-4
15 SGTC_2164 5685496 3.46 200.0 µM 1.00E-4 33 2.70E-4
16 SGTC_3153 9100258 3.45 49.5 µM 1.07E-4 43 2.85E-4
17 SGTC_2544 sphondin 3.28 68.5 µM 2.15E-4 RNA pol III & RNase P/MRP 43 5.26E-4
18 SGTC_2096 5468907 3.27 200.0 µM 2.25E-4 25 5.46E-4
19 SGTC_2853 9015042 3.26 58.4 µM 2.27E-4 48 5.52E-4
20 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.22 70.0 µM 2.70E-4 redox potentiating 115 6.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 5.08E-28 YDR031W MIC14 hom Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.143 8.34E-17 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.143 9.79E-17 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.125 3.19E-13 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.112 8.90E-11 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.109 2.63E-10 YPL063W TIM50 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
0.109 2.87E-10 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.108 3.61E-10 YML107C PML39 hom Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes
0.105 1.03E-9 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.105 1.23E-9 YOR057W SGT1 het Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
0.103 1.94E-9 YNR017W TIM23 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
0.102 3.10E-9 YMR128W ECM16 het Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
0.101 4.14E-9 YPR042C PUF2 hom Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins
0.101 4.80E-9 YDR057W YOS9 hom ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family
0.101 5.05E-9 YIL063C YRB2 het Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential