YDL242W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL242W / YDL242W

Click on Significant Values for Screen Details ID:SGTC_78|Compound:0336-0123|FD-Score:-3.10|P-value:4.36E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.97|P-value:6.13E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:2.90|P-value:8.10E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:-3.13|P-value:3.83E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.25|P-value:2.04E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.19|P-value:2.60E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:2.96|P-value:6.49E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:4.40|P-value:9.22E-7 ID:SGTC_502|Compound:l-744,832|FD-Score:3.08|P-value:4.11E-4 ID:SGTC_1115|Compound:galangin|FD-Score:2.89|P-value:8.48E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.71|P-value:3.36E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.41|P-value:1.26E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.85|P-value:1.46E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.10|P-value:3.83E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.80|P-value:1.81E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.54|P-value:6.08E-5 ID:SGTC_1739|Compound:st037196|FD-Score:4.93|P-value:4.59E-8 ID:SGTC_1872|Compound:amphotericin b|FD-Score:2.84|P-value:9.98E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.13|P-value:3.90E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.12|P-value:3.46E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.45|P-value:8.78E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.35|P-value:1.39E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.14|P-value:3.68E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.25|P-value:2.03E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-2.92|P-value:8.59E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.42|P-value:9.94E-5 ID:SGTC_3313|Compound:9133968|FD-Score:2.87|P-value:9.15E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.10|P-value:4.36E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.97|P-value:6.13E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:2.90|P-value:8.10E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:-3.13|P-value:3.83E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.25|P-value:2.04E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.19|P-value:2.60E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:2.96|P-value:6.49E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:4.40|P-value:9.22E-7 ID:SGTC_502|Compound:l-744,832|FD-Score:3.08|P-value:4.11E-4 ID:SGTC_1115|Compound:galangin|FD-Score:2.89|P-value:8.48E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.71|P-value:3.36E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.41|P-value:1.26E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.85|P-value:1.46E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.10|P-value:3.83E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.80|P-value:1.81E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.54|P-value:6.08E-5 ID:SGTC_1739|Compound:st037196|FD-Score:4.93|P-value:4.59E-8 ID:SGTC_1872|Compound:amphotericin b|FD-Score:2.84|P-value:9.98E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.13|P-value:3.90E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.12|P-value:3.46E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.45|P-value:8.78E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.35|P-value:1.39E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.14|P-value:3.68E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.25|P-value:2.03E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-2.92|P-value:8.59E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.42|P-value:9.94E-5 ID:SGTC_3313|Compound:9133968|FD-Score:2.87|P-value:9.15E-4

Top fitness defect scores for YDL242W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1739 st037196 4.93 92.5 µM 4.59E-8 5 4.21E-7
2 SGTC_418 lividomycin a 4.40 100.0 µM 9.22E-7 6 5.52E-6
3 SGTC_1132 3456-3614 3.85 2.5 µM 1.46E-5 tubulin folding & SWR complex 54 5.93E-5
4 SGTC_1571 st070080 3.80 73.4 µM 1.81E-5 20 7.11E-5
5 SGTC_1718 roemerine 3.54 11.9 µM 6.08E-5 redox potentiating 76 2.01E-4
6 SGTC_2346 9031566 3.45 143.8 µM 8.78E-5 Golgi 44 2.76E-4
7 SGTC_2960 9079389 3.42 6.0 µM 9.94E-5 49 3.08E-4
8 SGTC_2756 carbadox 3.35 75.1 µM 1.39E-4 82 4.10E-4
9 SGTC_2831 7999036 3.25 19.5 µM 2.03E-4 81 5.69E-4
10 SGTC_290 2043-6722 3.25 48.1 µM 2.04E-4 32 5.71E-4
11 SGTC_294 k038-0071 3.19 157.0 µM 2.60E-4 ubiquinone biosynthesis & proteasome 101 7.04E-4
12 SGTC_1991 st073000 3.12 8.9 µM 3.46E-4 NEO1 121 9.01E-4
13 SGTC_1202 1988-0068 3.10 29.6 µM 3.83E-4 RNA processing & uracil transport 63 9.82E-4
14 SGTC_502 l-744,832 3.08 89.3 µM 4.11E-4 calcium & mitochondrial duress 73 0.00104
15 SGTC_130 0136-0219 2.97 337.7 µM 6.13E-4 69 0.00147
16 SGTC_299 1273-0059 2.96 1.4 µM 6.49E-4 61 0.00155
17 SGTC_182 3448-4371 2.90 550.5 µM 8.10E-4 62 0.00187
18 SGTC_1115 galangin 2.89 695.7 nM 8.48E-4 RPP1 & pyrimidine depletion 66 0.00195
19 SGTC_3313 9133968 2.87 57.0 µM 9.15E-4 44 0.00208
20 SGTC_1872 amphotericin b 2.84 148.0 nM 9.98E-4 RNA pol III & RNase P/MRP 76 0.00224

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.194 7.09E-30 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.147 8.96E-18 YJR149W_p YJR149W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.141 2.90E-16 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.140 3.08E-16 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.136 2.82E-15 YOR375C GDH1 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication
0.122 1.24E-12 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.118 8.59E-12 YOL147C PEX11 hom Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
0.103 2.21E-9 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.101 3.94E-9 YBR147W RTC2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter
0.098 1.50E-8 YDL171C GLT1 hom NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
0.095 3.18E-8 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.095 3.20E-8 YKL185W ASH1 hom Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.094 4.69E-8 YCL055W KAR4 hom Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone
0.092 8.45E-8 YLL028W TPO1 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
0.092 1.03E-7 YFR025C HIS2 hom Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control