YDL243C / AAD4

Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL243C / AAD4

Click on Significant Values for Screen Details ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.02|P-value:7.63E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.15|P-value:6.27E-6 ID:SGTC_736|Compound:0958-0254|FD-Score:3.28|P-value:2.89E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-2.94|P-value:9.29E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.11|P-value:7.63E-6 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.43|P-value:1.54E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.90|P-value:2.02E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.36|P-value:2.08E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.67|P-value:5.03E-5 ID:SGTC_1266|Compound:0828-0227|FD-Score:2.94|P-value:9.90E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.39|P-value:1.68E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-4.06|P-value:8.80E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.82|P-value:3.00E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-3.77|P-value:3.30E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.03|P-value:7.29E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.74|P-value:3.07E-7 ID:SGTC_2396|Compound:5342950|FD-Score:-3.64|P-value:5.77E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.37|P-value:1.98E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.63|P-value:5.64E-7 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.33|P-value:2.59E-6 ID:SGTC_2717|Compound:st081029|FD-Score:-3.39|P-value:1.62E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.48|P-value:1.26E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.44|P-value:1.50E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.65|P-value:4.98E-7 ID:SGTC_2878|Compound:9043973|FD-Score:3.28|P-value:2.89E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.07|P-value:6.32E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.03|P-value:6.70E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.06|P-value:6.64E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.21|P-value:3.79E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.34|P-value:2.28E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.76|P-value:3.77E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.02|P-value:7.63E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.15|P-value:6.27E-6 ID:SGTC_736|Compound:0958-0254|FD-Score:3.28|P-value:2.89E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-2.94|P-value:9.29E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.11|P-value:7.63E-6 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.43|P-value:1.54E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.90|P-value:2.02E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.36|P-value:2.08E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.67|P-value:5.03E-5 ID:SGTC_1266|Compound:0828-0227|FD-Score:2.94|P-value:9.90E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.39|P-value:1.68E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-4.06|P-value:8.80E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.82|P-value:3.00E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-3.77|P-value:3.30E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.03|P-value:7.29E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.74|P-value:3.07E-7 ID:SGTC_2396|Compound:5342950|FD-Score:-3.64|P-value:5.77E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.37|P-value:1.98E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.63|P-value:5.64E-7 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.33|P-value:2.59E-6 ID:SGTC_2717|Compound:st081029|FD-Score:-3.39|P-value:1.62E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.48|P-value:1.26E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.44|P-value:1.50E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.65|P-value:4.98E-7 ID:SGTC_2878|Compound:9043973|FD-Score:3.28|P-value:2.89E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.07|P-value:6.32E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.03|P-value:6.70E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.06|P-value:6.64E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.21|P-value:3.79E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.34|P-value:2.28E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.76|P-value:3.77E-5

Top fitness defect scores for YDL243C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2310 7668677 4.74 200.0 µM 3.07E-7 15 1.07E-6
2 SGTC_2824 7998404 4.65 52.0 µM 4.98E-7 18 1.66E-6
3 SGTC_2635 hydroquinidine 4.63 100.0 µM 5.64E-7 11 1.86E-6
4 SGTC_2690 usnic acid 4.33 100.0 µM 2.59E-6 21 7.38E-6
5 SGTC_662 k832-1615 4.15 104.0 µM 6.27E-6 16 1.64E-5
6 SGTC_1040 k898-0338 4.11 155.0 µM 7.63E-6 18 1.96E-5
7 SGTC_1088 bifonazole 3.90 369.0 nM 2.02E-5 16 4.74E-5
8 SGTC_1583 clindamycin 3.82 39.6 µM 3.00E-5 mitochondrial processes 18 6.78E-5
9 SGTC_3145 9085516 3.76 49.5 µM 3.77E-5 fatty acid desaturase (OLE1) 36 8.33E-5
10 SGTC_2718 lomofungin 3.48 53.0 µM 1.26E-4 mitochondrial processes 23 2.48E-4
11 SGTC_2723 salbutamol 3.44 83.6 µM 1.50E-4 12 2.91E-4
12 SGTC_1077 5-fluorocytosine 3.43 377.0 nM 1.54E-4 exosome 31 2.99E-4
13 SGTC_2500 5-alpha-androstan-3,17-dione 3.37 61.4 µM 1.98E-4 58 3.75E-4
14 SGTC_1118 chelidonine 3.36 707.5 nM 2.08E-4 35 3.91E-4
15 SGTC_3143 9086658 3.34 49.5 µM 2.28E-4 77 4.26E-4
16 SGTC_736 0958-0254 3.28 92.6 µM 2.89E-4 Golgi 55 5.27E-4
17 SGTC_2878 9043973 3.28 26.0 µM 2.89E-4 39 5.28E-4
18 SGTC_3057 9095946 3.21 49.5 µM 3.79E-4 Golgi 32 6.75E-4
19 SGTC_2880 9042983 3.07 58.4 µM 6.32E-4 fatty acid desaturase (OLE1) 66 0.00107
20 SGTC_2987 9018338 3.06 71.4 µM 6.64E-4 RPP1 & pyrimidine depletion 69 0.00112

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.23E-14 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.104 1.49E-9 YOR326W MYO2 het Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication
0.104 1.52E-9 YKR015C_p YKR015C_p hom Putative protein of unknown function
0.098 1.45E-8 YPL222W_p FMP40_p hom Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.096 2.90E-8 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.096 2.94E-8 YBR193C MED8 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.092 1.04E-7 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.087 4.56E-7 YCL075W YCL075W hom Pseudogene: encodes fragment of Ty Pol protein
0.086 6.85E-7 YOR228C YOR228C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.084 1.23E-6 YPL200W CSM4 hom Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements
0.080 3.25E-6 YGL057C GEP7 hom Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.080 3.42E-6 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.079 4.34E-6 YKR030W GMH1 hom Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
0.077 7.27E-6 YDR361C BCP1 het Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
0.076 9.68E-6 YPR015C_p YPR015C_p hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest