YDR003W-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR003W-A / YDR003W-A

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:-3.94|P-value:9.81E-5 ID:SGTC_228|Compound:caffeine|FD-Score:3.98|P-value:9.76E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.63|P-value:6.44E-8 ID:SGTC_282|Compound:k297-0036|FD-Score:3.76|P-value:2.19E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:4.46|P-value:1.49E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:5.12|P-value:7.81E-7 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.64|P-value:2.94E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.76|P-value:1.87E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.93|P-value:1.66E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.87|P-value:1.26E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.95|P-value:9.35E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:-3.61|P-value:3.26E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.71|P-value:2.57E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.72|P-value:4.81E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:4.40|P-value:1.84E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:-3.85|P-value:1.40E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:-5.54|P-value:8.37E-8 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.78|P-value:3.66E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.71|P-value:2.53E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:7.04|P-value:1.94E-11 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.87|P-value:1.44E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.43|P-value:6.68E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:-3.27|P-value:9.88E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.37|P-value:8.03E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.69|P-value:2.80E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.82|P-value:1.71E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.65|P-value:3.21E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.57|P-value:4.21E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.78|P-value:1.98E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.35|P-value:8.64E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.49|P-value:4.84E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.44|P-value:6.32E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.51|P-value:5.16E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.86|P-value:1.51E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.54|P-value:4.52E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.71|P-value:4.35E-8 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.84|P-value:1.60E-4 ID:SGTC_2706|Compound:st078239|FD-Score:4.19|P-value:4.29E-5 ID:SGTC_2822|Compound:7994718|FD-Score:4.79|P-value:3.55E-6 ID:SGTC_2824|Compound:7998404|FD-Score:3.40|P-value:7.35E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.96|P-value:1.65E-6 ID:SGTC_2964|Compound:9083345|FD-Score:4.33|P-value:2.44E-5 ID:SGTC_2978|Compound:9011784|FD-Score:4.28|P-value:3.04E-5 ID:SGTC_2981|Compound:9013952|FD-Score:-4.32|P-value:2.22E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-3.28|P-value:9.70E-4 ID:SGTC_3027|Compound:9089541|FD-Score:-3.49|P-value:4.85E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.48|P-value:5.55E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.55|P-value:9.89E-6 ID:SGTC_3126|Compound:9127922|FD-Score:3.67|P-value:3.00E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-3.55|P-value:3.95E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.31|P-value:8.73E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.63|P-value:3.41E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.45|P-value:6.23E-4 ID:SGTC_3237|Compound:9133362|FD-Score:4.75|P-value:4.29E-6 ID:SGTC_3244|Compound:9134489|FD-Score:3.41|P-value:7.12E-4 ID:SGTC_3270|Compound:9137563|FD-Score:5.88|P-value:1.73E-8 ID:SGTC_3275|Compound:9138069|FD-Score:4.05|P-value:7.30E-5 ID:SGTC_3356|Compound:9151811|FD-Score:4.69|P-value:5.51E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.94|P-value:9.81E-5 ID:SGTC_228|Compound:caffeine|FD-Score:3.98|P-value:9.76E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.63|P-value:6.44E-8 ID:SGTC_282|Compound:k297-0036|FD-Score:3.76|P-value:2.19E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:4.46|P-value:1.49E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:5.12|P-value:7.81E-7 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.64|P-value:2.94E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.76|P-value:1.87E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.93|P-value:1.66E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.87|P-value:1.26E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.95|P-value:9.35E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:-3.61|P-value:3.26E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.71|P-value:2.57E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.72|P-value:4.81E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:4.40|P-value:1.84E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:-3.85|P-value:1.40E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:-5.54|P-value:8.37E-8 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.78|P-value:3.66E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.71|P-value:2.53E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:7.04|P-value:1.94E-11 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.87|P-value:1.44E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.43|P-value:6.68E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:-3.27|P-value:9.88E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.37|P-value:8.03E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.69|P-value:2.80E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.82|P-value:1.71E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.65|P-value:3.21E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.57|P-value:4.21E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.78|P-value:1.98E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.35|P-value:8.64E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.49|P-value:4.84E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.44|P-value:6.32E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.51|P-value:5.16E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.86|P-value:1.51E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.54|P-value:4.52E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.71|P-value:4.35E-8 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.84|P-value:1.60E-4 ID:SGTC_2706|Compound:st078239|FD-Score:4.19|P-value:4.29E-5 ID:SGTC_2822|Compound:7994718|FD-Score:4.79|P-value:3.55E-6 ID:SGTC_2824|Compound:7998404|FD-Score:3.40|P-value:7.35E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.96|P-value:1.65E-6 ID:SGTC_2964|Compound:9083345|FD-Score:4.33|P-value:2.44E-5 ID:SGTC_2978|Compound:9011784|FD-Score:4.28|P-value:3.04E-5 ID:SGTC_2981|Compound:9013952|FD-Score:-4.32|P-value:2.22E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-3.28|P-value:9.70E-4 ID:SGTC_3027|Compound:9089541|FD-Score:-3.49|P-value:4.85E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.48|P-value:5.55E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.55|P-value:9.89E-6 ID:SGTC_3126|Compound:9127922|FD-Score:3.67|P-value:3.00E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-3.55|P-value:3.95E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.31|P-value:8.73E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.63|P-value:3.41E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.45|P-value:6.23E-4 ID:SGTC_3237|Compound:9133362|FD-Score:4.75|P-value:4.29E-6 ID:SGTC_3244|Compound:9134489|FD-Score:3.41|P-value:7.12E-4 ID:SGTC_3270|Compound:9137563|FD-Score:5.88|P-value:1.73E-8 ID:SGTC_3275|Compound:9138069|FD-Score:4.05|P-value:7.30E-5 ID:SGTC_3356|Compound:9151811|FD-Score:4.69|P-value:5.51E-6

Top fitness defect scores for YDR003W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1276 0871-0068 7.04 94.2 µM 1.94E-11 2 9.47E-13
2 SGTC_3270 9137563 5.88 49.5 µM 1.73E-8 RPP1 & pyrimidine depletion 1 2.04E-9
3 SGTC_2501 sodium tetradecyl sulfate 5.71 13.4 µM 4.35E-8 8 5.78E-9
4 SGTC_236 1509-0011 5.63 5.3 µM 6.44E-8 300 9.01E-9
5 SGTC_310 1273-0058 5.12 1.1 µM 7.81E-7 mitochondrial stress 178 1.51E-7
6 SGTC_2858 9025781 4.96 9.0 µM 1.65E-6 sphingolipid biosynthesis & PDR1 68 3.51E-7
7 SGTC_2822 7994718 4.79 71.4 µM 3.55E-6 10 8.32E-7
8 SGTC_1159 4092-0538 4.78 61.2 µM 3.66E-6 13 8.60E-7
9 SGTC_3237 9133362 4.75 49.5 µM 4.29E-6 18 1.03E-6
10 SGTC_1069 diphenylcyclopropenone 4.72 8.5 µM 4.81E-6 17 1.17E-6
11 SGTC_3356 9151811 4.69 4.5 µM 5.51E-6 cell wall 13 1.37E-6
12 SGTC_3099 9120367 4.55 49.5 µM 9.89E-6 8 2.64E-6
13 SGTC_300 r073-0011 4.46 5.0 µM 1.49E-5 11 4.19E-6
14 SGTC_1078 idebenone 4.40 36.1 µM 1.84E-5 Golgi 29 5.33E-6
15 SGTC_2964 9083345 4.33 53.4 µM 2.44E-5 15 7.33E-6
16 SGTC_2978 9011784 4.28 43.0 µM 3.04E-5 22 9.38E-6
17 SGTC_2706 st078239 4.19 82.5 µM 4.29E-5 7 1.38E-5
18 SGTC_3275 9138069 4.05 49.5 µM 7.30E-5 6 2.52E-5
19 SGTC_228 caffeine 3.98 993.1 µM 9.76E-5 9 3.49E-5
20 SGTC_1279 0874-0590 3.87 65.2 µM 1.44E-4 33 5.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.39E-18 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.147 1.28E-17 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.144 4.19E-17 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.143 9.09E-17 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.143 9.99E-17 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.140 4.27E-16 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.132 1.62E-14 YKL016C ATP7 hom Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.128 8.69E-14 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.126 2.12E-13 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.126 2.24E-13 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.126 2.55E-13 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.125 3.25E-13 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.123 8.95E-13 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.119 4.95E-12 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.119 5.26E-12 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit