YDR004W / RAD57

Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR004W / RAD57

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.37|P-value:2.25E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.41|P-value:1.95E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:3.46|P-value:6.22E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:7.14|P-value:1.39E-11 ID:SGTC_93|Compound:0109-0045|FD-Score:6.69|P-value:2.19E-10 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:11.70|P-value:6.88E-28 ID:SGTC_223|Compound:busulfan|FD-Score:3.95|P-value:1.14E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:9.12|P-value:8.71E-18 ID:SGTC_244|Compound:nsc-207895|FD-Score:7.59|P-value:7.16E-13 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.35|P-value:8.99E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.02|P-value:9.46E-9 ID:SGTC_251|Compound:melphalan|FD-Score:4.07|P-value:7.24E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.81|P-value:3.54E-6 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:10.20|P-value:1.15E-21 ID:SGTC_268|Compound:camptothecin|FD-Score:10.30|P-value:2.43E-22 ID:SGTC_272|Compound:doxorubicin|FD-Score:7.72|P-value:2.90E-13 ID:SGTC_273|Compound:hydroxyurea|FD-Score:8.06|P-value:2.66E-14 ID:SGTC_318|Compound:1488-0629|FD-Score:4.38|P-value:2.15E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.58|P-value:9.55E-6 ID:SGTC_429|Compound:1112-0049|FD-Score:9.31|P-value:1.83E-18 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.34|P-value:9.07E-4 ID:SGTC_441|Compound:propafenone|FD-Score:4.00|P-value:9.59E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.40|P-value:7.55E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.88|P-value:1.45E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.96|P-value:1.10E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:8.80|P-value:1.11E-16 ID:SGTC_580|Compound:1123-0028|FD-Score:4.45|P-value:1.62E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.58|P-value:4.11E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.64|P-value:3.41E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.09|P-value:6.85E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:4.19|P-value:4.70E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:4.84|P-value:3.09E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.31|P-value:2.87E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.50|P-value:5.39E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:8.69|P-value:2.56E-16 ID:SGTC_829|Compound:1635-0120|FD-Score:16.60|P-value:3.05E-54 ID:SGTC_830|Compound:4076-0286|FD-Score:3.64|P-value:3.43E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:8.35|P-value:3.24E-15 ID:SGTC_1079|Compound:idarubicin|FD-Score:10.40|P-value:1.67E-22 ID:SGTC_1082|Compound:camptothecin|FD-Score:9.13|P-value:8.31E-18 ID:SGTC_1105|Compound:epirubicin|FD-Score:6.01|P-value:1.04E-8 ID:SGTC_1170|Compound:0310-0127|FD-Score:7.00|P-value:3.31E-11 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.76|P-value:2.24E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.98|P-value:1.01E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:7.86|P-value:1.13E-13 ID:SGTC_1298|Compound:1079-1278|FD-Score:5.18|P-value:6.80E-7 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.36|P-value:8.52E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.68|P-value:6.29E-6 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.03|P-value:8.45E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.98|P-value:1.02E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.50|P-value:6.70E-10 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:6.62|P-value:3.35E-10 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.20|P-value:4.49E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.42|P-value:7.09E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.41|P-value:1.97E-5 ID:SGTC_1632|Compound:st005650|FD-Score:4.29|P-value:3.16E-5 ID:SGTC_1653|Compound:st012112|FD-Score:3.32|P-value:9.85E-4 ID:SGTC_1707|Compound:st032323|FD-Score:12.30|P-value:5.60E-31 ID:SGTC_1718|Compound:roemerine|FD-Score:8.46|P-value:1.47E-15 ID:SGTC_1732|Compound:st034308|FD-Score:3.37|P-value:8.34E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.48|P-value:5.74E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.59|P-value:4.07E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.59|P-value:4.08E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.39|P-value:2.11E-5 ID:SGTC_1930|Compound:st074634|FD-Score:10.10|P-value:2.81E-21 ID:SGTC_1995|Compound:st072814|FD-Score:3.40|P-value:7.45E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.85|P-value:2.96E-6 ID:SGTC_2043|Compound:5101342|FD-Score:3.33|P-value:9.43E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.32|P-value:2.76E-5 ID:SGTC_2128|Compound:5255449|FD-Score:3.84|P-value:1.71E-4 ID:SGTC_2171|Compound:5739187|FD-Score:4.23|P-value:3.95E-5 ID:SGTC_2218|Compound:6965428|FD-Score:3.65|P-value:3.27E-4 ID:SGTC_2229|Compound:7354935|FD-Score:4.02|P-value:8.88E-5 ID:SGTC_2298|Compound:7976326|FD-Score:3.87|P-value:1.49E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.96|P-value:1.85E-6 ID:SGTC_2306|Compound:7482397|FD-Score:4.77|P-value:4.33E-6 ID:SGTC_2308|Compound:7584454|FD-Score:5.55|P-value:1.13E-7 ID:SGTC_2315|Compound:7733312|FD-Score:4.59|P-value:9.02E-6 ID:SGTC_2460|Compound:5552655|FD-Score:3.44|P-value:6.54E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.45|P-value:1.80E-7 ID:SGTC_2624|Compound:nerol|FD-Score:-3.37|P-value:8.37E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.52|P-value:5.12E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:5.27|P-value:4.33E-7 ID:SGTC_2699|Compound:st077704|FD-Score:-5.24|P-value:5.05E-7 ID:SGTC_2851|Compound:9015922|FD-Score:-5.82|P-value:2.82E-8 ID:SGTC_2852|Compound:9023854|FD-Score:-6.92|P-value:5.53E-11 ID:SGTC_2853|Compound:9015042|FD-Score:6.35|P-value:1.58E-9 ID:SGTC_2858|Compound:9025781|FD-Score:3.58|P-value:4.23E-4 ID:SGTC_2968|Compound:9090663|FD-Score:4.02|P-value:8.84E-5 ID:SGTC_3021|Compound:9087658|FD-Score:-3.65|P-value:3.35E-4 ID:SGTC_3247|Compound:9135149|FD-Score:12.00|P-value:2.55E-29 ID:SGTC_3254|Compound:9136651|FD-Score:4.82|P-value:3.45E-6 ID:SGTC_3344|Compound:9148862|FD-Score:4.42|P-value:1.83E-5 ID:SGTC_3345|Compound:9148410|FD-Score:-3.55|P-value:4.70E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.65|P-value:3.31E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.37|P-value:2.25E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.41|P-value:1.95E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:3.46|P-value:6.22E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:7.14|P-value:1.39E-11 ID:SGTC_93|Compound:0109-0045|FD-Score:6.69|P-value:2.19E-10 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:11.70|P-value:6.88E-28 ID:SGTC_223|Compound:busulfan|FD-Score:3.95|P-value:1.14E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:9.12|P-value:8.71E-18 ID:SGTC_244|Compound:nsc-207895|FD-Score:7.59|P-value:7.16E-13 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.35|P-value:8.99E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.02|P-value:9.46E-9 ID:SGTC_251|Compound:melphalan|FD-Score:4.07|P-value:7.24E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.81|P-value:3.54E-6 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:10.20|P-value:1.15E-21 ID:SGTC_268|Compound:camptothecin|FD-Score:10.30|P-value:2.43E-22 ID:SGTC_272|Compound:doxorubicin|FD-Score:7.72|P-value:2.90E-13 ID:SGTC_273|Compound:hydroxyurea|FD-Score:8.06|P-value:2.66E-14 ID:SGTC_318|Compound:1488-0629|FD-Score:4.38|P-value:2.15E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.58|P-value:9.55E-6 ID:SGTC_429|Compound:1112-0049|FD-Score:9.31|P-value:1.83E-18 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.34|P-value:9.07E-4 ID:SGTC_441|Compound:propafenone|FD-Score:4.00|P-value:9.59E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.40|P-value:7.55E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.88|P-value:1.45E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.96|P-value:1.10E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:8.80|P-value:1.11E-16 ID:SGTC_580|Compound:1123-0028|FD-Score:4.45|P-value:1.62E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.58|P-value:4.11E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.64|P-value:3.41E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.09|P-value:6.85E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:4.19|P-value:4.70E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:4.84|P-value:3.09E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.31|P-value:2.87E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.50|P-value:5.39E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:8.69|P-value:2.56E-16 ID:SGTC_829|Compound:1635-0120|FD-Score:16.60|P-value:3.05E-54 ID:SGTC_830|Compound:4076-0286|FD-Score:3.64|P-value:3.43E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:8.35|P-value:3.24E-15 ID:SGTC_1079|Compound:idarubicin|FD-Score:10.40|P-value:1.67E-22 ID:SGTC_1082|Compound:camptothecin|FD-Score:9.13|P-value:8.31E-18 ID:SGTC_1105|Compound:epirubicin|FD-Score:6.01|P-value:1.04E-8 ID:SGTC_1170|Compound:0310-0127|FD-Score:7.00|P-value:3.31E-11 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.76|P-value:2.24E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.98|P-value:1.01E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:7.86|P-value:1.13E-13 ID:SGTC_1298|Compound:1079-1278|FD-Score:5.18|P-value:6.80E-7 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.36|P-value:8.52E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.68|P-value:6.29E-6 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.03|P-value:8.45E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.98|P-value:1.02E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.50|P-value:6.70E-10 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:6.62|P-value:3.35E-10 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.20|P-value:4.49E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.42|P-value:7.09E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.41|P-value:1.97E-5 ID:SGTC_1632|Compound:st005650|FD-Score:4.29|P-value:3.16E-5 ID:SGTC_1653|Compound:st012112|FD-Score:3.32|P-value:9.85E-4 ID:SGTC_1707|Compound:st032323|FD-Score:12.30|P-value:5.60E-31 ID:SGTC_1718|Compound:roemerine|FD-Score:8.46|P-value:1.47E-15 ID:SGTC_1732|Compound:st034308|FD-Score:3.37|P-value:8.34E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.48|P-value:5.74E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.59|P-value:4.07E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.59|P-value:4.08E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.39|P-value:2.11E-5 ID:SGTC_1930|Compound:st074634|FD-Score:10.10|P-value:2.81E-21 ID:SGTC_1995|Compound:st072814|FD-Score:3.40|P-value:7.45E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.85|P-value:2.96E-6 ID:SGTC_2043|Compound:5101342|FD-Score:3.33|P-value:9.43E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.32|P-value:2.76E-5 ID:SGTC_2128|Compound:5255449|FD-Score:3.84|P-value:1.71E-4 ID:SGTC_2171|Compound:5739187|FD-Score:4.23|P-value:3.95E-5 ID:SGTC_2218|Compound:6965428|FD-Score:3.65|P-value:3.27E-4 ID:SGTC_2229|Compound:7354935|FD-Score:4.02|P-value:8.88E-5 ID:SGTC_2298|Compound:7976326|FD-Score:3.87|P-value:1.49E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.96|P-value:1.85E-6 ID:SGTC_2306|Compound:7482397|FD-Score:4.77|P-value:4.33E-6 ID:SGTC_2308|Compound:7584454|FD-Score:5.55|P-value:1.13E-7 ID:SGTC_2315|Compound:7733312|FD-Score:4.59|P-value:9.02E-6 ID:SGTC_2460|Compound:5552655|FD-Score:3.44|P-value:6.54E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.45|P-value:1.80E-7 ID:SGTC_2624|Compound:nerol|FD-Score:-3.37|P-value:8.37E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.52|P-value:5.12E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:5.27|P-value:4.33E-7 ID:SGTC_2699|Compound:st077704|FD-Score:-5.24|P-value:5.05E-7 ID:SGTC_2851|Compound:9015922|FD-Score:-5.82|P-value:2.82E-8 ID:SGTC_2852|Compound:9023854|FD-Score:-6.92|P-value:5.53E-11 ID:SGTC_2853|Compound:9015042|FD-Score:6.35|P-value:1.58E-9 ID:SGTC_2858|Compound:9025781|FD-Score:3.58|P-value:4.23E-4 ID:SGTC_2968|Compound:9090663|FD-Score:4.02|P-value:8.84E-5 ID:SGTC_3021|Compound:9087658|FD-Score:-3.65|P-value:3.35E-4 ID:SGTC_3247|Compound:9135149|FD-Score:12.00|P-value:2.55E-29 ID:SGTC_3254|Compound:9136651|FD-Score:4.82|P-value:3.45E-6 ID:SGTC_3344|Compound:9148862|FD-Score:4.42|P-value:1.83E-5 ID:SGTC_3345|Compound:9148410|FD-Score:-3.55|P-value:4.70E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.65|P-value:3.31E-4

Top fitness defect scores for YDR004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_829 1635-0120 16.60 117.0 µM 3.05E-54 DNA damage response 3 5.51E-62
2 SGTC_1707 st032323 12.30 6.3 µM 5.60E-31 DNA damage response 5 2.77E-35
3 SGTC_3247 9135149 12.00 49.5 µM 2.55E-29 DNA damage response 3 2.21E-33
4 SGTC_219 mitoxanthrone 11.70 164.4 µM 6.88E-28 DNA intercalators 4 9.73E-32
5 SGTC_1079 idarubicin 10.40 2.4 µM 1.67E-22 DNA damage response 2 1.47E-25
6 SGTC_268 camptothecin 10.30 39.6 µM 2.43E-22 DNA damage response 8 2.25E-25
7 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 10.20 44.4 nM 1.15E-21 DNA damage response 13 1.34E-24
8 SGTC_1930 st074634 10.10 34.3 µM 2.81E-21 RNA pol III & RNase P/MRP 2 3.74E-24
9 SGTC_429 1112-0049 9.31 25.5 µM 1.83E-18 DNA damage response 3 6.29E-21
10 SGTC_1082 camptothecin 9.13 424.9 nM 8.31E-18 DNA damage response 7 3.57E-20
11 SGTC_238 5hr heat shock (37°C) + nsc-638432 9.12 8.9 µM 8.71E-18 heat shock/prefoldin 7 3.77E-20
12 SGTC_558 k064-0027 8.80 21.3 µM 1.11E-16 DNA damage response 2 6.99E-19
13 SGTC_824 1304-0008 8.69 100.0 µM 2.56E-16 DNA damage response 1 1.82E-18
14 SGTC_1718 roemerine 8.46 11.9 µM 1.47E-15 redox potentiating 4 1.35E-17
15 SGTC_915 methyl methanesulfonate (MMS) 8.35 110.0 mM 3.24E-15 DNA damage response 4 3.33E-17
16 SGTC_273 hydroxyurea 8.06 18.1 mM 2.66E-14 heme biosynthesis & mitochondrial translocase 5 3.72E-16
17 SGTC_1290 0986-0249 7.86 10.2 µM 1.13E-13 DNA intercalators 3 1.96E-15
18 SGTC_272 doxorubicin 7.72 8.1 µM 2.90E-13 anthracycline transcription coupled DNA repair 2 5.77E-15
19 SGTC_244 nsc-207895 7.59 1.3 µM 7.16E-13 DNA damage response 6 1.62E-14
20 SGTC_73 0327-0325 7.14 16.2 µM 1.39E-11 DNA damage response 9 4.84E-13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.648 0 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.561 2.55E-277 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.527 1.56E-239 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.420 1.47E-143 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.416 1.32E-140 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.415 1.38E-139 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.366 8.53E-107 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.353 2.48E-99 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.353 3.98E-99 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.322 7.15E-82 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.244 1.23E-46 YGL087C MMS2 hom Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
0.238 2.26E-44 YLR032W RAD5 hom DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress
0.236 8.87E-44 YDR369C XRS2 hom Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
0.223 3.87E-39 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.210 7.80E-35 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress