YDR006C / SOK1

Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR006C / SOK1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.60|P-value:7.79E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:3.81|P-value:3.14E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.14|P-value:4.87E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:2.99|P-value:8.41E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.80|P-value:3.29E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:5.09|P-value:4.52E-8 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.13|P-value:5.73E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.01|P-value:8.87E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.06|P-value:7.36E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:5.08|P-value:4.79E-8 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.41|P-value:1.96E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.08|P-value:5.88E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.18|P-value:4.75E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.55|P-value:8.82E-7 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.57|P-value:8.64E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.09|P-value:8.74E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:2.94|P-value:9.77E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.01|P-value:7.72E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.50|P-value:1.17E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.65|P-value:6.23E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-3.47|P-value:1.53E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.06|P-value:7.25E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.08|P-value:6.74E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.85|P-value:2.60E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-4.04|P-value:1.31E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.17|P-value:4.29E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.59|P-value:7.18E-7 ID:SGTC_2586|Compound:curcumin|FD-Score:3.07|P-value:6.13E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.75|P-value:4.74E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-3.06|P-value:7.36E-4 ID:SGTC_2915|Compound:7971052|FD-Score:3.04|P-value:6.84E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.59|P-value:8.17E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.24|P-value:3.23E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.08|P-value:6.02E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:3.60|P-value:7.79E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:3.81|P-value:3.14E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.14|P-value:4.87E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:2.99|P-value:8.41E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.80|P-value:3.29E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:5.09|P-value:4.52E-8 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.13|P-value:5.73E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.01|P-value:8.87E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.06|P-value:7.36E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:5.08|P-value:4.79E-8 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.41|P-value:1.96E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.08|P-value:5.88E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.18|P-value:4.75E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.55|P-value:8.82E-7 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.57|P-value:8.64E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.09|P-value:8.74E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:2.94|P-value:9.77E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.01|P-value:7.72E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.50|P-value:1.17E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.65|P-value:6.23E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-3.47|P-value:1.53E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.06|P-value:7.25E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.08|P-value:6.74E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.85|P-value:2.60E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-4.04|P-value:1.31E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.17|P-value:4.29E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.59|P-value:7.18E-7 ID:SGTC_2586|Compound:curcumin|FD-Score:3.07|P-value:6.13E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.75|P-value:4.74E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-3.06|P-value:7.36E-4 ID:SGTC_2915|Compound:7971052|FD-Score:3.04|P-value:6.84E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.59|P-value:8.17E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.24|P-value:3.23E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.08|P-value:6.02E-4

Top fitness defect scores for YDR006C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_266 formosanin C 5.09 406.0 nM 4.52E-8 sphingolipid biosynthesis & PDR1 44 1.76E-7
2 SGTC_902 1120-0002 5.08 2.1 µM 4.79E-8 azole & statin 25 1.86E-7
3 SGTC_2581 avocatin a 4.59 64.0 µM 7.18E-7 sphingolipid biosynthesis & PDR1 39 2.20E-6
4 SGTC_1230 0170-0365 4.55 3.8 µM 8.82E-7 endomembrane recycling 41 2.66E-6
5 SGTC_1916 st067606 4.09 49.2 µM 8.74E-6 34 2.16E-5
6 SGTC_2389 9091542 3.85 195.5 µM 2.60E-5 iron homeostasis 35 5.86E-5
7 SGTC_3 0833-0587 3.81 95.6 µM 3.14E-5 redox potentiating 24 6.96E-5
8 SGTC_227 fluconazole 3.80 33.5 µM 3.29E-5 azole & statin 93 7.28E-5
9 SGTC_1997 st073024 3.65 93.8 µM 6.23E-5 12 1.30E-4
10 SGTC_1 0258-0098 3.60 57.4 µM 7.79E-5 heme biosynthesis & mitochondrial translocase 15 1.60E-4
11 SGTC_2935 9038016 3.59 30.0 µM 8.17E-5 24 1.67E-4
12 SGTC_1368 1852-0141 3.57 284.0 µM 8.64E-5 ERG2 50 1.76E-4
13 SGTC_1991 st073000 3.50 8.9 µM 1.17E-4 NEO1 99 2.32E-4
14 SGTC_2973 9094665 3.24 18.0 µM 3.23E-4 NEO1 58 5.89E-4
15 SGTC_2574 2',4'-dihydroxychalcone 3.17 14.6 µM 4.29E-4 47 7.62E-4
16 SGTC_102 gallobenzophenone 3.14 83.6 µM 4.87E-4 redox potentiating 68 8.56E-4
17 SGTC_937 3122-0005 3.08 46.7 µM 5.88E-4 58 0.00102
18 SGTC_3340 9146634 3.08 11.1 µM 6.02E-4 50 0.00104
19 SGTC_2586 curcumin 3.07 80.0 µM 6.13E-4 iron homeostasis 109 0.00106
20 SGTC_2915 7971052 3.04 15.2 µM 6.84E-4 22 0.00117

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 5.68E-27 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p
0.157 5.55E-20 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.155 1.78E-19 YGL164C YRB30 hom RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
0.152 9.33E-19 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.146 1.95E-17 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.146 1.84E-17 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.144 4.10E-17 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.136 3.01E-15 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.135 3.77E-15 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.128 8.19E-14 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.121 1.67E-12 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.111 9.92E-11 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.109 2.12E-10 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.108 3.09E-10 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.107 5.15E-10 YOR154W_p SLP1_p hom Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p