YDR009W / GAL3

Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR009W / GAL3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.05|P-value:2.83E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:2.81|P-value:7.84E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.92|P-value:5.01E-4 ID:SGTC_263|Compound:alizarin|FD-Score:5.00|P-value:8.95E-9 ID:SGTC_264|Compound:promethazine|FD-Score:-4.03|P-value:2.56E-6 ID:SGTC_277|Compound:nystatin|FD-Score:-2.98|P-value:3.80E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.01|P-value:3.55E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:2.86|P-value:6.42E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.38|P-value:7.03E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.84|P-value:7.04E-6 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.21|P-value:1.41E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:2.86|P-value:6.42E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.93|P-value:4.68E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.26|P-value:1.24E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-2.75|P-value:9.40E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-4.00|P-value:3.06E-6 ID:SGTC_1314|Compound:1222-0010|FD-Score:2.77|P-value:9.30E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.12|P-value:2.10E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.86|P-value:5.97E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.22|P-value:1.01E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:3.56|P-value:3.09E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.91|P-value:4.83E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.40|P-value:6.52E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.71|P-value:1.37E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.62|P-value:2.26E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.18|P-value:1.75E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-3.22|P-value:1.36E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-2.98|P-value:3.75E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.97|P-value:3.55E-6 ID:SGTC_2336|Compound:9001819|FD-Score:2.85|P-value:6.74E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.35|P-value:8.07E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.13|P-value:1.98E-4 ID:SGTC_2709|Compound:st078560|FD-Score:4.38|P-value:3.96E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.06|P-value:2.42E-6 ID:SGTC_2851|Compound:9015922|FD-Score:3.29|P-value:1.05E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.03|P-value:3.09E-4 ID:SGTC_3323|Compound:9138564|FD-Score:2.78|P-value:8.84E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.05|P-value:2.83E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:2.81|P-value:7.84E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.92|P-value:5.01E-4 ID:SGTC_263|Compound:alizarin|FD-Score:5.00|P-value:8.95E-9 ID:SGTC_264|Compound:promethazine|FD-Score:-4.03|P-value:2.56E-6 ID:SGTC_277|Compound:nystatin|FD-Score:-2.98|P-value:3.80E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.01|P-value:3.55E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:2.86|P-value:6.42E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.38|P-value:7.03E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.84|P-value:7.04E-6 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.21|P-value:1.41E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:2.86|P-value:6.42E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.93|P-value:4.68E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.26|P-value:1.24E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-2.75|P-value:9.40E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-4.00|P-value:3.06E-6 ID:SGTC_1314|Compound:1222-0010|FD-Score:2.77|P-value:9.30E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.12|P-value:2.10E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.86|P-value:5.97E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.22|P-value:1.01E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:3.56|P-value:3.09E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.91|P-value:4.83E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.40|P-value:6.52E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.71|P-value:1.37E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.62|P-value:2.26E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.18|P-value:1.75E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-3.22|P-value:1.36E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-2.98|P-value:3.75E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.97|P-value:3.55E-6 ID:SGTC_2336|Compound:9001819|FD-Score:2.85|P-value:6.74E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.35|P-value:8.07E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.13|P-value:1.98E-4 ID:SGTC_2709|Compound:st078560|FD-Score:4.38|P-value:3.96E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.06|P-value:2.42E-6 ID:SGTC_2851|Compound:9015922|FD-Score:3.29|P-value:1.05E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.03|P-value:3.09E-4 ID:SGTC_3323|Compound:9138564|FD-Score:2.78|P-value:8.84E-4

Top fitness defect scores for YDR009W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_263 alizarin 5.00 107.9 µM 8.95E-9 iron homeostasis 35 2.88E-7
2 SGTC_2709 st078560 4.38 56.0 µM 3.96E-7 4 5.81E-6
3 SGTC_1525 8-methoxypsoralen 4.22 92.5 µM 1.01E-6 DNA damage response 22 1.23E-5
4 SGTC_2750 bromebric acid 4.06 70.2 µM 2.42E-6 27 2.45E-5
5 SGTC_1739 st037196 3.62 92.5 µM 2.26E-5 33 1.45E-4
6 SGTC_1527 coumarin 3.56 137.0 µM 3.09E-5 37 1.87E-4
7 SGTC_1584 6-fluoro-dl-tryptophan 3.40 90.0 µM 6.52E-5 mitochondrial processes 33 3.38E-4
8 SGTC_651 3253-0966 3.38 34.4 µM 7.03E-5 calcium & mitochondrial duress 55 3.59E-4
9 SGTC_2398 5228213 3.35 48.8 µM 8.07E-5 iron homeostasis 73 4.01E-4
10 SGTC_2851 9015922 3.29 71.4 µM 1.05E-4 71 4.94E-4
11 SGTC_1009 4106-0057 3.26 9.9 µM 1.24E-4 30 5.67E-4
12 SGTC_1740 st038286 3.18 13.2 µM 1.75E-4 66 7.42E-4
13 SGTC_300 r073-0011 3.01 5.0 µM 3.55E-4 61 0.00131
14 SGTC_234 nsc-17383 2.92 10.7 µM 5.01E-4 ERG2 67 0.00173
15 SGTC_329 k048-0121 2.86 21.3 µM 6.42E-4 RSC & ERG11 57 0.00211
16 SGTC_935 2996-0153 2.86 430.0 µM 6.42E-4 PDR1 73 0.00211
17 SGTC_2336 9001819 2.85 198.7 µM 6.74E-4 heme biosynthesis & mitochondrial translocase 123 0.00219
18 SGTC_183 3914-0051 2.81 30.6 µM 7.84E-4 60S ribosome export 80 0.00247
19 SGTC_3323 9138564 2.78 53.9 µM 8.84E-4 91 0.00272
20 SGTC_1314 1222-0010 2.77 41.1 µM 9.30E-4 58 0.00284

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.60E-13 YDR274C_d YDR274C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.111 1.38E-10 YGR084C MRP13 hom Mitochondrial ribosomal protein of the small subunit
0.107 5.05E-10 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.104 1.53E-9 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.099 1.02E-8 YDR273W DON1 hom Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
0.098 1.14E-8 YPL119C DBP1 hom Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress
0.098 1.25E-8 YHR134W WSS1 hom Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response
0.095 3.89E-8 YHR101C BIG1 het Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
0.090 1.59E-7 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.089 2.32E-7 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.087 3.91E-7 YGL010W_p YGL010W_p hom Putative protein of unknown function; YGL010W is not an essential gene
0.085 8.99E-7 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.083 1.51E-6 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.083 1.66E-6 YPR027C_p YPR027C_p hom Putative protein of unknown function
0.082 1.79E-6 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication